DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik3 and MARK3

DIOPT Version :10

Sequence 1:NP_611361.4 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:NP_001122390.2 Gene:MARK3 / 4140 HGNCID:6897 Length:753 Species:Homo sapiens


Alignment Length:672 Identity:235/672 - (34%)
Similarity:332/672 - (49%) Gaps:166/672 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRH 97
            |:...:|.|.|.|||||||||.||||.:|:|..:|||||||||.||...|.|.|||:.|:|.|.|
Human    48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112

  Fly    98 PHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHR 162
            |:|.:|:||:|::..:||:.|||..||:||:|||:|||||.||...|.|:||||.|||::.:|||
Human   113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHR 177

  Fly   163 DLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVV 227
            ||||||:|||.|||||:|||||||.:..|..|.|:||||||||||:|||.:||||:.|:|||||:
Human   178 DLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVI 242

  Fly   228 LYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL 292
            ||.||.|:|||||:.:.||:.||:.||:||||:||.:||.|::..||:.|.:|.|::||:|.||:
Human   243 LYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307

  Fly   293 SEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSV------VMTHMLQLPGLTAD 351
            :....| .|.:.|.:                        |:||..      :|..|    |.:.:
Human   308 NAGHEE-DELKPFVE------------------------PELDISDQKRIDIMVGM----GYSQE 343

  Fly   352 MIAQSVHEQRFDNIYAIYNLL-------------------------------------HDKLQQ- 378
            .|.:|:.:.::|.|.|.|.||                                     |.|:|: 
Human   344 EIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRS 408

  Fly   379 --RRRENQRLQHHAS------LAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALG 435
              ..::.:|...||.      :||.:..:||..      ...:|::.      :|:..:|.||: 
Human   409 VSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTA------DSDLKEDG------ISSRKSSGSAV- 460

  Fly   436 FGWSDVAVDLEKYGDFELECLARSN----DPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQ 496
             |...:|......|:       .||    |.|...:..:..:....:|..|||:|.    |..|:
Human   461 -GGKGIAPASPMLGN-------ASNPNKADIPERKKSSTVPSSNTASGGMTRRNTY----VCSER 513

  Fly   497 ALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRR 561
            ..|:.:                          .::||.. .|.||.||   :.||....|.....
Human   514 TTADRH--------------------------SVIQNGK-ENSTIPDQ---RTPVASTHSISSAA 548

  Fly   562 ASDGGANLHIYYP----ATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQC 622
            ..|     .|.:|    :..|..|  |.::..||.|...|   ..|....|.:||:         
Human   549 TPD-----RIRFPRGTASRSTFHG--QPRERRTATYNGPP---ASPSLSHEATPLS--------- 594

  Fly   623 CQENATGECN--EELQSYMQKR 642
             |..:.|..|  .:|.|.:.:|
Human   595 -QTRSRGSTNLFSKLTSKLTRR 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_611361.4 Protein Kinases, catalytic domain 40..292 CDD:473864 155/251 (62%)
UBA_SIK 335..380 CDD:270523 15/90 (17%)
MARK3NP_001122390.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
STKc_MARK 55..307 CDD:270974 155/251 (62%)
UBA_MARK3_4 325..367 CDD:270590 12/45 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 370..600 55/304 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655
MARK1-3_C 654..751 CDD:213381
Blue background indicates that the domain is not in the aligned region.

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