DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sik3 and MARK1

DIOPT Version :9

Sequence 1:NP_001188969.1 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:NP_001273053.1 Gene:MARK1 / 4139 HGNCID:6896 Length:796 Species:Homo sapiens


Alignment Length:825 Identity:247/825 - (29%)
Similarity:374/825 - (45%) Gaps:196/825 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 PAAAPPTSSTPQNYKVP---STSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIK 70
            |...|..||:.||  :|   ::...:.|:...:|.|.|:|||||||||.||||.:::|..:||:|
Human    27 PHIQPTKSSSRQN--IPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVK 89

  Fly    71 IIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRM 135
            |||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:|||
Human    90 IIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRM 154

  Fly   136 KEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGS 200
            ||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:|||
Human   155 KEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGS 219

  Fly   201 PPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQEC 265
            |||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||.:|
Human   220 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDC 284

  Fly   266 EQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDS 330
            |.|::.:||:.|.:|.:::||:|.||::....|                       ..|...::.
Human   285 ENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEE-----------------------EELKPYTEP 326

  Fly   331 PPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYS 395
            .|..:......::...|...|.|..::..|::|.:.|.|.||       .|:....:...||:  
Human   327 DPDFNDTKRIDIMVTMGFARDEINDALINQKYDEVMATYILL-------GRKPPEFEGGESLS-- 382

  Fly   396 RSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSN 460
                   :..:..||.|        .|.|:|:...|.|                  .|: :.||.
Human   383 -------SGNLCQRSRP--------SSDLNNSTLQSPA------------------HLK-VQRSI 413

  Fly   461 DPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPP-IDFKCPPQCSDPTQPVPYY 524
            ......:..|.|||                          |::|| :.:...||.:.        
Human   414 SANQKQRRFSDHAG--------------------------PSIPPAVSYTKRPQANS-------- 444

  Fly   525 PVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMD 589
                  ::::.....   |:.:.:.   :|:::.|.::.          .....:|||.:     
Human   445 ------VESEQKEEW---DKDVARK---LGSTTVGSKSE----------MTASPLVGPER----- 482

  Fly   590 TAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTE 654
                             ::.|.:...:|..........|..|......|:..:.|..    ....
Human   483 -----------------KKSSTIPSNNVYSGGSMARRNTYVCERTTDRYVALQNGKD----SSLT 526

  Fly   655 DLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERP-----PVIP--PEIIREVESRMKRDYLP 712
            ::||:..|.|||...:...|:..|.:::  ::.:..|     |.|.  .|..|...:..:.....
Human   527 EMSVSSISSAGSSVASAVPSARPRHQKS--MSTSGHPIKVTLPTIKDGSEAYRPGSTTQRVPAAS 589

  Fly   713 PTLKSLSQSPPNGTYPVGAALPMGMSK--------------------GLSPPHSLPLVAAA--GG 755
            |:..|:|.:.|:.|     ..|.|.|.                    ..||.|.....|.|  |.
Human   590 PSAHSISTATPDRT-----RFPRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETGAFAHARRGT 649

  Fly   756 SVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASEGSKSQ 800
            |..:::....:..|    :.|:  ||...||....|..|...|.:
Human   650 STGIISKITSKFVR----RDPS--EGEASGRTDTSRSTSGEPKER 688

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_001188969.1 PKc_like 40..292 CDD:304357 153/251 (61%)
S_TKc 41..292 CDD:214567 153/250 (61%)
UBA_SIK 335..380 CDD:270523 9/44 (20%)
MARK1NP_001273053.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 6/14 (43%)
STKc_MARK 59..311 CDD:270974 153/251 (61%)
S_TKc 60..311 CDD:214567 153/250 (61%)
UBA_MARK1 331..371 CDD:270588 9/46 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..495 30/231 (13%)
MARK1-3_C 697..794 CDD:213381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0586
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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