DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik3 and Gm5157

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_011249060.1	Gene:	Gm5157 / 381937	MGIID:	3648211	Length:	301	Species:	Mus musculus

Alignment Length:	286	Identity:	113/286 - (39%)
Similarity:	172/286 - (60%)	Gaps:	16/286 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYE 105
            |::..|:|:|.|:|||.|.::.|.|.||:||:..|   :||.:...||..|:|||.||:|.:|:.
Mouse    27 YKMLNTLGEGKFSVVKRAFHVPTSTSVAVKILQNT---KEYTSPICREARIMKSLSHPNIIKLFH 88

  Fly   106 VMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVL 170
            |::.:...|||.|||..||:.|.::..|.::|.:..|:|.|:|.||.|||...:||||:||.|:|
Mouse    89 VVQRRETTYLVMEYASEGELQDRIIKVGSLEESKTRRLFAQIVHAVQYCHDHHIVHRDIKASNIL 153

  Fly   171 LDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGA 235
            :|...|.||.|||.:.....|..|..:||:.||.|||:.|..:|:||..|||||||:|:.:|.|.
Mouse   154 IDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGPPVDIWSLGVLLFLMVSGN 218

  Fly   236 LPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL--SEWQSE 298
            |||.||:.::||..::...|.||..:..:...:|..:|::.|.||.||.||::|..:  ||
Mouse   219 LPFQGKSFVDLKQEIISANFSIPSHVPIDIFNVIIELLMINPSRRPTIHQIMRHPMIRGSE---- 279

  Fly   299 MQEQERFGDMSPGSGTVSKSASTSSL 324
                   ..:.|.|..:|::...::|
Mouse   280 -------ACLPPTSTQISQAPQATAL 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	107/250 (43%)
		S_TKc	41..292	CDD:214567	107/250 (43%)
		UBA_SIK	335..380	CDD:270523
Gm5157	XP_011249060.1	STKc_AMPK-like	26..273	CDD:270905	106/248 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810