DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and CG8485

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_610942.2	Gene:	CG8485 / 36579	FlyBaseID:	FBgn0033915	Length:	860	Species:	Drosophila melanogaster

Alignment Length:	785	Identity:	216/785 - (27%)
Similarity:	328/785 - (41%)	Gaps:	189/785 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRL 103
            |.|:||:|:|.|:|||||||.::.|..|||:|::|||.|::......|:|:..:|.::||::.||
  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82

  Fly   104 YEVMESQSMIYLVTEYAPNGEIFDHLVA-NGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAE 167
            |||:::|:.:|||.|....|:::|:::. :..:.|..|.:.|.|::.|:.|||:..|||||||.|
  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147

  Fly   168 NVLLDKDMN-IKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYAL 231
            ||:..:.:. :||.||||||.:..|..|:|:|||..|:|||:..|..||.|..|||||||:||.|
  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212

  Fly   232 VCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL---S 293
            |||..||:.....|..:.::..|:.:|..:|.:|..||.:|||.:|.:|.|:::|....||   .
  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLKPID 277

  Fly   294 EWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVH 358
            |..|.....|.|..:          .|...||...      .:.::..|:.....:.:.|.|::.
  Fly   278 EPDSTTSTSEHFLPL----------VSREQLGEED------HAFIIQKMINGNIASKEEILQALD 326

  Fly   359 EQRFDNIYAIYNLLHDKLQQRRRE----NQRLQHHASLAY-SRSRK--------TSITTGVVDRS 410
            :.::::|.|.|.||.:...:||||    .|||.:.||:.. ..|||        |....|.|..|
  Fly   327 KNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPEKPSPTEAQKGGVPIS 391

  Fly   411 ---EPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPV-NAQHLSA 471
               .|..|.:.|...|...:...|          .|..|...:...||.|..|:..| ::....|
  Fly   392 INVTPAAQFANDGGKPDKRSRKCS----------IVREEDEEESATECTAVGNELKVTSSSRREA 446

  Fly   472 HAGGGVNGANTRRHTVGPGDVAHEQALANPNVP-------------------------------- 504
            .:....:.:...|.:..||:....:.:||..||
  Fly   447 FSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDEDT 511

  Fly   505 ---------------PIDFKCP--------------PQCS------DPTQP---------VPYYP 525
                           |...|.|              |.||      |.|:.         |...|
  Fly   512 LSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFVGDTP 576

  Fly   526 VNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDT 590
            |...| ..:..|:.:...|..|.||  .|::|          |...:...:|:|.|..:||..
  Fly   577 VRFRM-HRRDSHDDSSDSQDQLYPP--PGSAS----------NAGNFISKSGSVSGKKEGQSQ-- 626

  Fly   591 AGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTED 655
               |..||..:|.         |.:|.:|....|.|         :.::.|....:|.
  Fly   627 ---YKEPNNKSDE---------NRKSHSQKNRKQHN---------KDHVDKHSHAERQ------- 663

  Fly   656 LSVAHGSGAGSQSQAPTTSSNMRQRR----TGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLK 716
                    ....|.|.|.:|..|:||    ..|..:||         .:|.|.| .|.|......
  Fly   664 --------LADSSTATTGNSTNRRRRIRESQSLDRITE---------AQEYEMR-HRCYAESEAA 710

  Fly   717 SLSQS 721
            |.|.|
  Fly   711 SSSSS 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	108/253 (43%)
		S_TKc	41..292	CDD:214567	108/252 (43%)
		UBA_SIK	335..380	CDD:270523	8/44 (18%)
CG8485	NP_610942.2	STKc_SNRK	16..273	CDD:270976	109/254 (43%)
		S_TKc	20..273	CDD:214567	108/252 (43%)
		UBA_SNRK	296..338	CDD:270524	7/47 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010