Protein Alignment Sik3 and mark3a

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_021336197.1
• Gene: mark3a / 334300
• ZFINID: ZDB-GENE-030131-6232
• Length: 746
• Species: Danio rerio
• Alignment Length: 723
• Identity: 235/723 - (32%)
• Similarity: 352/723 - (48%)
• Gaps: 158/723 - (21%)

  Fly    38 VGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITR 102
            :|.|.|.|||||||||.||||.:|:|.::||||:||||.||...|.|..||:.|:|:|.||:|.:
Zfish    54 IGNYRLLKTIGKGNFAKVKLARHILTGSEVAIKMIDKTQLNPTSLQKLSREVTIMKNLNHPNIVK 118

  Fly   103 LYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAE 167
            |:||:|::..::||.|||..||:||:|||:|||||.||...|.|:||||.|||::.:||||||||
Zfish   119 LFEVIETEKTLFLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHRDLKAE 183

  Fly   168 NVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALV 232
            |:|||.|||||:|||||||.:..|:.|.|:||||||||||:|||.:||||:.|:|||||:||.||
Zfish   184 NLLLDGDMNIKIADFGFSNEFMVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLV 248

  Fly   233 CGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQS 297
            .|:|||||:.:.||:.||:.||:||||:||.:||.|::..||:.|.:|.|::||:|.||::   |
Zfish   249 SGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPAKRGTLEQIMKERWIN---S 310

  Fly   298 EMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRF 362
            ..::.|    :.|         .|......||. .::|.:|..      |.:.:.|.:|:.:..:
Zfish   311 GFEDDE----LKP---------FTEPDADISDQ-KRIDVIVGM------GFSKEKIHESLFKMNY 355

  Fly   363 DNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNA 427
            |.:.|||.||..|..:...::   ..:::|:.:::|                        |.|..
Zfish   356 DEVTAIYLLLGRKTHEEVSDS---SSNSNLSVAKTR------------------------PSSEM 393

  Fly   428 NASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAG-GGVNGANTRRHTVGPGD 491
            |:.|.:                                  ||..... .......:|||:...|.
Zfish   394 NSQSPS----------------------------------HLKVQRSISSSESRKSRRHSEQVGV 424

  Fly   492 VAHEQALANPNVPPI--DFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLT-IKDQ---HLLKPP 550
            ||:.....:..|.|:  |.:...:.....:.:|.:....|:|.|....|.| |.|:   :.:...
Zfish   425 VANNALSNSKRVVPVTADSEVKQEGGVIARKLPNHSPPSPLLGNANNPNKTEIPDRKKGNSITSN 489

  Fly   551 VVMGASSFGRR------------------------------ASDGGANLHIYYPATGTVVGPAQ- 584
            .:.|:.|..||                              :.|.||:.|    :..|.|.|.:
Zfish   490 NISGSGSMSRRNTYVCTERNNTDRLSVIPNGKENSVSLSPSSRDPGASTH----SISTSVTPDKT 550

  Fly   585 -------------GQQMD--TAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEE 634
                         ||..|  ||.|...|.....|.:....:.|..:..:::  .:.|.:...::.
Zfish   551 RFPRGSASRSTFHGQVRDRRTATYNGPPASPAQPRSRANANNLLTKLTSKL--TRRNMSFRFSKR 613

  Fly   635 LQSYMQKRG---GTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPP 696
            :.:..::.|   |:.||..|..:......|.....:|...|.|.|        .|.|    :.|.
Zfish   614 VSTEFERSGRFEGSSRHVSGDQQKDEGKDGKDGKPRSLRFTWSMN--------TTST----MEPA 666

  Fly   697 EIIREVES 704
            :||.|:.:
Zfish   667 DIINEIRT 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	153/251 (61%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
mark3a	XP_021336197.1	STKc_MARK	56..308	CDD:270974	153/251 (61%)
		UBA_like_SF	326..368	CDD:473871	13/48 (27%)
		MARK1-3_C	647..744	CDD:213381	10/40 (25%)