Protein Alignment Sik3 and LOC3291504

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_061514913.1
• Gene: LOC3291504 / 3291504
• VectorBaseID: AGAMI1_015110
• Length: 1418
• Species: Anopheles gambiae
• Alignment Length: 1219
• Identity: 321/1219 - (26%)
• Similarity: 452/1219 - (37%)
• Gaps: 460/1219 - (37%)

  Fly    13 PPTSSTPQNYKVPSTSKISVDKLLR----------------------VGYYELEKTIGKGNFAVV 55
            |..:.:...:..|.::|..|.::.|                      :|.|:|.|||||||||.|
Mosquito   438 PVVAKSKPIHDKPKSAKARVQEVKRDKGSPNMQMRGTPARWRSGEEHIGKYKLLKTIGKGNFAKV 502

  Fly    56 KLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYA 120
            |||.::.|..:|||||||||.||...|.|.:||:.|:|.|.||:|.:|::|:|::..:|||.|||
Mosquito   503 KLAKHVPTNKEVAIKIIDKTQLNPSSLQKLYREVRIMKMLDHPNIVKLFQVIETEKTLYLVMEYA 567

  Fly   121 PNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFS 185
            ..||:||:|||:|:|||.||...|.|:||||.|||::.::||||||||:|||.:||||:||||||
Mosquito   568 SGGEVFDYLVAHGKMKEKEARAKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSEMNIKIADFGFS 632

  Fly   186 NHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRV 250
            |.:..|:.|.|:||||||||||:|||.:||||:.|:|||||:||.||.|:|||||.|:.||:.||
Mosquito   633 NEFTPGSKLDTFCGSPPYAAPELFQGRKYDGPEVDVWSLGVILYTLVSGSLPFDGATLKELRERV 697

  Fly   251 VLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLS------------EWQSEMQEQE 303
            :.||:||||:||.:||.|::..||:.|.:|..::.|:|.:|::            |...::::|:
Mosquito   698 LRGKYRIPFYMSTDCEVLLKKFLVLNPSKRANLETIMKDKWMNMGYEDDELKPYVEPLPDLKDQK 762

  Fly   304 RFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAI 368
            |.|  ..|:..|.|              |:|.::|..      |.....|..|:....:|:::|.
Mosquito   763 RIG--KTGNQAVFK--------------PRLKALVAM------GYNRQDIEDSLANTMYDDVFAT 805

  Fly   369 YNLLHDKLQQRRRENQRLQHHASL---------AYSRSRKTSITTGVVDRSEPVKQESLDRLSPL 424
            |.||..|......:..|.....||         |...|:..|.|...|.|       |:...|..
Mosquito   806 YLLLGRKSTDSESDGSRSGSSLSLRNIAGNEGAAAGNSQVQSPTHRGVHR-------SISASSTK 863

  Fly   425 SNANASSSALGFGWSDVAVDLEKYGDFELECLAR--SNDPPVNAQHLSAHA------GGGVNGAN 481
            .:..|||                 |...|:...|  :...|..|...:|.|      ||||.|..
Mosquito   864 PSRRASS-----------------GGETLQIFQRFITGVGPTTAVAAAAAAAAVGAGGGGVGGGG 911

  Fly   482 TRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHL 546
                  |.|.|....|
Mosquito   912 ------GGGAVVGSMA------------------------------------------------- 921

  Fly   547 LKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSP 611
                           |:.|||       .||||||...|.             ||
Mosquito   922 ---------------AAGGGA-------GTGTVVGGGTGG-------------GT---------- 941

  Fly   612 LNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSN 676
                         .|.||  |..|      .|.|..|:.|       ..|||.|: |:..:.|||
Mosquito   942 -------------ANVTG--NSVL------AGATNNHSSG-------TGGSGGGA-SERTSISSN 977

  Fly   677 MRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGL 741
            .:::.|           |....|:|..:|         |.:.:|.|
Mosquito   978 FKRQNT-----------IDSATIKENTAR---------LAAQNQRP------------------- 1003

  Fly   742 SPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASEGSKSQFQGPLQ 806
                      |:..:.|:.:.:|..|.....::   ....:|..:|.|    |.||::
Mosquito  1004 ----------ASSITKPITSVDNSSISSPAKAR---TTSSSTSTKYDP----SNGSRT------- 1044

  Fly   807 ECQSLQKGIAQRNFLVAPSPPLLENSISLPGSPIHGKPGMGLQLALRRGHDIEVPPEAIKNLMPA 871
                           |.||                                        ..|||.
Mosquito  1045 ---------------VGPS----------------------------------------AGLMPR 1054

  Fly   872 LDRLVKEQRVSFEIANKIISTHVVPMD---LAPL----LGLAAHASSAAAVSGGHLDQSHFTHLQ 929
            ....:.|:..|.|..|....    |..   :||:    .|.:|.|:::.|.|||
Mosquito  1055 RSTTLYEKTSSTEKTNSTTD----PTSNSFVAPIPEFNRGNSASAATSGAGSGG----------- 1104

  Fly   930 QQQQQQHMLSFSVSPLSMPQGGAVNASLTSAKQMFGQPICGYTQYQPMTLALQPQHQQQLVGQFS 994
                               .||....:.:.:....|....|.|                 .|..:
Mosquito  1105 -------------------GGGGGGVANSGSANTTGTGTTGVT-----------------TGSTA 1133

  Fly   995 SINLGASNSNSSSGCQSPVFSTSFSGSCSPNPYLPGAAGGSSPLHQITKGISGLSTGCAGGS--- 1056
            ....|.....:::|......|.|..|:.|   ...|..|||:        |.|...|..||:
Mosquito  1134 GGGGGGGGGTTTTGTMGGSGSVSVGGAGS---VTGGGNGGSN--------IGGGGGGGGGGTGKG 1187

  Fly  1057 ITRGTSAASEGAAA-----AAAANQPLDLSMDVCGGVMDQQPTDYAATNWFMPTASYYDMKPLNL 1116
            ..:..|.:|.|.:|     :||.|.||..||                       .:...:.|...
Mosquito  1188 HVKSASVSSPGPSADSTTNSAATNDPLRQSM-----------------------VNRNSLTPAVN 1229

  Fly  1117 SPAQPV---RVVPTPPASPNLCIIQEENGNGQMCHTISTGTPYAGCTGG 1162
            |..|||   |.||:          :....:||.  .....|.||| |||
Mosquito  1230 SSRQPVAFPRNVPS----------RSTFHSGQT--RARNSTVYAG-TGG 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	148/251 (59%)
		UBA_SIK	335..380	CDD:270523	10/44 (23%)
LOC3291504	XP_061514913.1	None