Protein Alignment Sik3 and Sik2

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_569972.1
• Gene: Sik2 / 31170
• FlyBaseID: FBgn0025625
• Length: 1398
• Species: Drosophila melanogaster
• Alignment Length: 1563
• Identity: 403/1563 - (25%)
• Similarity: 594/1563 - (38%)
• Gaps: 556/1563 - (35%)

  Fly     6 TAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIK 70
            |.||:   ||||......:.....:.:.:.:|||:|::|:|||||||||||||.:.:||.:||||
  Fly   109 TPGPS---PTSSAVGAGGISGKDLLKLKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIK 170

  Fly    71 IIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRM 135
            ||||:.|::..|.|.:||:.|:|.|:||||.:||:|||:::|||:|:|||..|||||::...|||
  Fly   171 IIDKSQLDQTNLQKVYREVEIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRM 235

  Fly   136 KEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGS 200
            .|..|...|.|::|||.|||::|:|||||||||:|||.:||||:||||||||::.|..|.|||||
  Fly   236 SESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFKPGELLATWCGS 300

  Fly   201 PPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQEC 265
            |||||||||:|.:|.||:.||||||||||.||||||||||.|:..|:.||:.|:||||||||.||
  Fly   301 PPYAAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIPFFMSSEC 365

  Fly   266 EQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDS 330
            |.|||.|||:||.|||||.||.:|||:.   .|:.|..          .::|    .:||:...:
  Fly   366 EHLIRRMLVLEPTRRYTIDQIKRHRWMC---PELLEHV----------LIAK----YNLGAERQT 413

  Fly   331 PPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYS 395
            ..:....::..|.:..|:.:|....|:.:..:|::.|||.||.|::..::.::..|...| ||.|
  Fly   414 SVEPSEDILRIMAEYVGIGSDKTRASLKKNTYDHVAAIYLLLQDRVSHKKEQSNGLGASA-LASS 477

  Fly   396 RSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLAR-S 459
            .|....|.:...|. :|.:|:|..:...:|.:           |.:|.|         :|..| |
  Fly   478 TSASRMIYSSRNDH-QPTQQQSQQQSKTISTS-----------SILAKD---------QCHKRLS 521

  Fly   460 NDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYY 524
            ....|.....:||||                        |.|.||.         ..|.....|.
  Fly   522 RHQTVLMSERNAHAG------------------------ATPTVPD---------PGPGYYAKYG 553

  Fly   525 PVNLPMLQNQPL--HNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQ 587
            |:.||:    ||  |:      ||                             ||.:.|  .|.:
  Fly   554 PLQLPL----PLTGHS------HL-----------------------------TGYLNG--GGVE 577

  Fly   588 MDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGC 652
            :|.:|.         ||.:: .:||
  Fly   578 VDASGI---------PLPMR-YTPL---------------------------------------- 592

  Fly   653 TEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKS 717
                              ||.:|                |.  |.......||:.|       .|
  Fly   593 ------------------PTAAS----------------PA--PSNCSSTSSRVGR-------HS 614

  Fly   718 LSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGG-----SVPLVAPNNRRIHRVVHSKLPT 777
            ||.|.|....||..:|.:..:..|:......::.|.||     .|||.   ::::|:.:...:
  Fly   615 LSSSSPRSHRPVAISLSIDNNPSLANLRCREMMEAGGGPVGAVGVPLA---SKQLHQTISEFI-- 674

  Fly   778 VQEGATIGRYSPVRRASEGSKSQFQGPLQECQSLQKGIAQRNFLVA---PSPPLLENSISLPGSP 839
                        :::::|           :|::|    .|::..||   ..||..|:|:.  |.|
  Fly   675 ------------IKQSTE-----------DCRAL----LQQSTAVAEGKDDPPKAESSVG--GVP 710

  Fly   840 IHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHVVPMDLAPLLG 904
               .|......:...|      ||:.....|.            ||..|.|.|
  Fly   711 ---PPASTTPTSSTAG------PESGSAPCPG------------EINGKTIKT------------ 742

  Fly   905 LAAHASSAAAVSGGHLDQSHFTHLQQQQQQQHMLSFSVSPLSMPQ--------------GGAVNA 955
               .:||::..|..:|.|| |.:....:..:...:...|||.:.|              ||....
  Fly   743 ---MSSSSSFDSKANLGQS-FRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVGSTNGSGGDSGQ 803

  Fly   956 SLTSAKQMFGQPICGYTQYQPMTLALQPQHQQQLVGQFSSINLGASNSNSSSGCQSPVFSTSFSG 1020
            ....||..      |.::.:...||                   ..:|::..||::...:.
  Fly   804 ETNDAKSN------GDSRSEKKVLA-------------------QGSSSTDEGCETDQGND---- 839

  Fly  1021 SCSPNPYLPGAAGGSSPLHQITKGISGLSTGCAGG--------SITR--GT-------------- 1061
                    ||:|.      |.:||.:|..:|.|.|        .:||  ||
  Fly   840 --------PGSAS------QESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSGQSHKMRSYAS 890

  Fly  1062 SAASEGAAAAAAANQPLDLSMDV--------CGGVMDQQPTDYAATNWFMPTASYYDMKPLNLSP 1118
            |::|.|..|.:|.:....||.::        |.|..|.  .|:|
  Fly   891 SSSSSGVLAGSAGSYSKSLSQNLSRGSSKSNCSGPYDS--LDFA--------------------- 932

  Fly  1119 AQPVRVVPTPPASPNLCIIQEENGNGQMCHTISTGTPYAGCTGGITPQICLTDVQGSEITLVALS 1183
                  :|:...|...|:     |:..|   ::|.||.:....||                   |
  Fly   933 ------LPSGKGSLPSCM-----GSSSM---LATPTPASASPAGI-------------------S 964

  Fly  1184 SDNSRDSEDSLEQ------HTPVMSLQGLIITEPSSDMPSIT-------RGI------------- 1222
            |::|  ||.||..      |.|.....||.:.:.|:..|:..       .|:
  Fly   965 SEHS--SERSLYGSHNSCIHMPGALPLGLGLPQSSASTPTPNPTPPPNGGGVTFLDKRSPIHFRE 1027

  Fly  1223 GRKASLDCDSGAGSHCPVASGSSHANQSQTQAQTEAQCRRGSDKSLGFSDDSLSNDSNNLSPCQE 1287
            ||:||    .|..:...::|||.........:....|.:|.....:           ..|...|:
  Fly  1028 GRRAS----DGLVAQGLLSSGSLLGTSRVYGSYRYEQAKRHGWLEI-----------QQLQQLQQ 1077

  Fly  1288 PSASSGFKSDSHSEMGDHTECGHLTPDSMCDSRRMSDEMC-------YEVP--------LPHECS 1337
            .:|.......:|.....|.   |..|.:.     ..:|:|       |.:|        |||
  Fly  1078 EAAVGHSHPHAHQHPHQHP---HPHPQAY-----GLEELCQFPNGQFYALPGKHHPLLTLPH--- 1131

  Fly  1338 NLDSTRILEMVKQTIDSTMPPKGFVLHKGSISSEDSGAESRHSSASNASTSNPLACEAAS--LLA 1400
                                      |....:....|   .||...:...:.||..|||:  .:.
  Fly  1132 --------------------------HHAHPAQHHHG---HHSLFHSGHQATPLLLEAAAGGDMY 1167

  Fly  1401 SHSGYGEPTTNLSLEYSGGLQIELQVCEGRSRDHHGAGKGIKLRRISGDQFEYGKICQQLISTIT 1465
            .|..|..|.....| |:                ||..|.|:   .:.....:...:.|||:....
  Fly  1168 GHGCYAPPPPPPGL-YT----------------HHQLGVGM---AVPMSPMQKPPLQQQLLQHRL 1212

  Fly  1466 MQQ 1468
            :||
  Fly  1213 LQQ 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	165/251 (66%)
		S_TKc	41..292	CDD:214567	165/250 (66%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)
Sik2	NP_569972.1	STKc_SIK	140..392	CDD:270973	165/251 (66%)
		S_TKc	141..392	CDD:214567	165/250 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D12637at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920