Protein Alignment Sik3 and RGD1560303

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_218667.4
• Gene: RGD1560303 / 292948
• RGDID: 1560303
• Length: 494
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 160/617 - (25%)
• Similarity: 249/617 - (40%)
• Gaps: 181/617 - (29%)

  Fly    25 PSTSKISV-DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFRE 88
            |||..:.: .:.:....|.:.|.:|:|....|:|:::.:|.|.||:|.:.|   :|.:...|..|
  Rat    12 PSTRSLGLFSEEVFTRQYTILKPLGQGGTTEVRLSSHRLTGTPVAVKALVK---HERHWASTMSE 73

  Fly    89 IAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHY 153
            :.|:|.|.|.:|..|.:|||::..||::.|.|....:.:.:...||:||.||..:|.||:||:.|
  Rat    74 VEIMKILNHNNIVSLLQVMETEQNIYIIMEVAQGDSLLNRVQKAGRLKEDEARGIFVQLLSALGY 138

  Fly   154 CHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPK 218
            ||.:|::|||||.:|:::|:..|:|:.|||....:..|..||..||:..:..||:|.||.|||||
  Rat   139 CHGKGIIHRDLKPDNIIVDEHGNVKIIDFGLGAKFLPGQKLKRLCGAFQFIPPELFLGLPYDGPK 203

  Fly   219 SDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTI 283
            .|||:|||:||.:|.|..||.|.|:.||...|:.|::.||:.:|::...:|..:|.|...:|.|.
  Rat   204 VDIWALGVLLYFMVTGFAPFSGTTLSELSKNVLQGRYDIPYNLSKDLRSMISLLLTVNARQRPTA 268

  Fly   284 KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGL 348
            :.:..|.||.||...:              |...:..||.        |..|.:|....:   |.
  Rat   269 QDLSSHPWLQEWGKTL--------------TFHSNRDTSF--------PNRDIMVAMENI---GF 308

  Fly   349 TADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPV 413
            ....|.:|:..::||...|.|.||            |:|
  Rat   309 HVQDIKESLKHKKFDETMATYLLL------------RVQ-------------------------- 335

  Fly   414 KQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVN 478
                                                                     |...|| |
  Rat   336 ---------------------------------------------------------ACQNGG-N 342

  Fly   479 GANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDP-TQPVPYYP---VNLPMLQNQPLHNL 539
            ...|:              |.||.|.|.     |..:|| |.|:|  |   .:.|.|:
  Rat   343 YVQTK--------------LLNPGVAPF-----PSAADPDTFPLP--PRRRASEPSLK------- 379

  Fly   540 TIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPL 604
                       :|:.:|...|....||.|..:....|     |..|:     ||   ..|.|||.
  Rat   380 -----------IVVASSEQQRLRQSGGTNAPVQPKKT-----PVMGR-----GY---KRCVTDPC 420

  Fly   605 AVQELSPLNEQSVAQMQCCQENATGECNEELQ 636
            .::..:.:|..:::.....|..:..|.:..||
  Rat   421 ILRRNTGMNVDTISFSASSQTLSDSERSRSLQ 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	97/251 (39%)
		S_TKc	41..292	CDD:214567	97/250 (39%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)
RGD1560303	XP_218667.4	STKc_AMPK-like	28..276	CDD:270905	97/250 (39%)
		S_TKc	29..277	CDD:214567	97/250 (39%)
		UBA_MARK_Par1	295..332	CDD:270522	10/39 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810