DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik3 and RGD1562638

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001094414.1	Gene:	RGD1562638 / 290818	RGDID:	1562638	Length:	654	Species:	Rattus norvegicus

Alignment Length:	779	Identity:	208/779 - (26%)
Similarity:	320/779 - (41%)	Gaps:	207/779 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 YYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLY 104
            :|.:..::|:|.|..||||::::|:||||||::.|:  |:..|.|:  ||.|:|||.||||.:|.
  Rat    23 HYRILASLGQGGFGEVKLASHLLTQTKVAIKVLPKS--NKNLLLKS--EIEIMKSLDHPHIIKLL 83

  Fly   105 EVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENV 169
            .::::...|::|.|:|..||:...:...|.:.|.|..|:|.|:|.|:.|||:||::|||:|.||:
  Rat    84 HIIDTNENIFIVLEHAVGGELLTRIEDFGYLPEEECNRLFRQMVLALQYCHQRGIIHRDIKPENI 148

  Fly   170 LLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCG 234
            |||...|:||:|||.|.....|..|.|.||:.||.|||:|....|||...|:||||||||.:..|
  Rat   149 LLDHKGNVKLSDFGLSTKIVMGQKLTTLCGTLPYCAPELFNLNGYDGQAIDVWSLGVVLYYMATG 213

  Fly   235 ALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEM 299
            .|||.|.|...:|.:::.|::.:.|.:|.:...:|..:|.|.|..|..:.:|::..||.
  Rat   214 CLPFQGFTYQAIKQKILSGRYSVNFRLSPDLWDVIAKLLTVNPRERPRVHEILRFNWLK------ 272

  Fly   300 QEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDN 364
            .|.|               .|.||||..:||.|  |..::..|..: |.....|.:|:.|::||.
  Rat   273 NENE---------------VSPSSLGGNTDSHP--DPTILVMMGDM-GYEQGQIRESLRERKFDQ 319

  Fly   365 IYAIYNLL------HDKLQQRRRENQRLQHHASLAYSRSRKTSITTG-----VVDRSEPVKQESL 418
            :.|.|.:|      .||..:.....|..|...|...:..::|::..|     :.....|.|.|||
  Rat   320 VMATYLMLREKACSEDKSIKTPHPTQCAQTLKSTGSTTEKQTTLRRGSSLPTLTTFYLPSKLESL 384

  Fly   419 DR---------LSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAG 474
            ::         :.|..|....|.:|..|...:              ::.:..|.:|..:.|....
  Rat   385 NKEKRTTMRHTMPPNLNCFNKSESLNKGRRTI--------------VSHTISPTLNCFNKSESLN 435

  Fly   475 GGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCP-----------------PQCSDPTQPVP 522
            .|..  ...|||:.|           ....|:...||                 ...|||
  Rat   436 KGKR--TIVRHTMPP-----------KKTSPVRRICPRLHKSFGMGSASEDSSKRNSSDP----- 482

  Fly   523 YYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLH--IYYPATGTVVGPAQG 585
                :|.:..:|..                |.|..:|...|...|.|.  ::|.|:
  Rat   483 ----SLTIFSSQSF----------------MSAFKYGSTYSKRKAFLQCILHYHAS--------- 518

  Fly   586 QQMDTAGYYINP----NCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQ 646
            |:.|.....|.|    |....|.::||..|                ||..:..|
  Rat   519 QEEDQYKTTIIPSGKLNTTVPPNSLQEDQP----------------TGHLHNVL----------- 556

  Fly   647 RHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVES-----RM 706
              |.|..::.::        |.::|..|:.        .|..|.|      .|:|.||     |.
  Rat   557 --TAGAVDNRNL--------QEKSPPFSTT--------ATKGEGP------AIKERESIPSSPRA 597

  Fly   707 KRDYLPPTLKSLSQSPPNGTY--PVGAALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIH 768
            .|:    ..:..||:||...:  .|...|..|..|||             ||:....|..:::|
  Rat   598 PRE----QFRGRSQTPPRAPFRRRVWKTLKSGFLKGL-------------GSLCCCLPIQKKVH 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	104/251 (41%)
		S_TKc	41..292	CDD:214567	104/250 (42%)
		UBA_SIK	335..380	CDD:270523	13/50 (26%)
RGD1562638	NP_001094414.1	STKc_AMPK-like	23..270	CDD:270905	104/250 (42%)
		UBA_MARK_Par1	290..329	CDD:270522	12/41 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..369		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..616		16/78 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810