Protein Alignment Sik3 and Nuak2

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_001007618.1
• Gene: Nuak2 / 289419
• RGDID: 1359167
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 198/711 - (27%)
• Similarity: 290/711 - (40%)
• Gaps: 200/711 - (28%)

  Fly    41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEY-LNKTFREIAILKSLRHPHITRLY 104
            ||..:|:|||.:..||.|.....:. ||||.|.|..:.:|. |....|||.|:.||.||||..::
  Rat    57 YEFLETLGKGTYGKVKKARESSGRL-VAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHIIAIH 120

  Fly   105 EVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENV 169
            ||.|:.|.|.:|.|||..|:::|::....|:.|.:|...|.|:|||:||||:.|:||||||.||:
  Rat   121 EVFENSSKIVIVMEYASRGDLYDYISERPRLNERDARHFFRQIVSALHYCHQNGIVHRDLKLENI 185

  Fly   170 LLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCG 234
            |||...|||:||||.||.|.:|..|:|:||||.||:||:..|..|.||:.|.|||||:||.||.|
  Rat   186 LLDASGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDSWSLGVLLYILVHG 250

  Fly   235 ALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEW--QS 297
            .:||||:....|..::..|.:|.|...|..| .|||.:|:|.|.||.|::.:..|.|:: |  .:
  Rat   251 TMPFDGQDHKTLVKQISSGAYREPCKPSDAC-GLIRWLLMVNPIRRATLEDVASHWWVN-WGYST 313

  Fly   298 EMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDS---VVMTHMLQLPGLTADMIAQSVHE 359
            .:.|||...:....||...:::....|  ...|.|.|::   |.......:||  .......:..
  Rat   314 RIGEQEALREGGHPSGDSGRASMADWL--RRSSRPLLENGAKVCSFFKQHVPG--GGSTGPGLER 374

  Fly   360 QRFDNIYAIYNLLHDKLQQRRREN---QRLQHH-ASLAYSRSRKTS--ITTGVVDR----SEPVK 414
            |.             .|::.|:||   |.||:. |....||..|.|  :..|::.:    |....
  Rat   375 QH-------------SLKKSRKENDMAQTLQNDPAEDTSSRPGKNSLKLPKGILKKKASPSSGEV 426

  Fly   415 QESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNG 479
            ||....|.|:||.
  Rat   427 QEGPQELRPVSNT---------------------------------------------------- 439

  Fly   480 ANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQ 544
                                                 |.||||..|: ||.             :
  Rat   440 -------------------------------------PGQPVPAIPL-LPR-------------K 453

  Fly   545 HLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQ-GQQMDTAGYYINPNCGTDPLAVQE 608
            .:||.         .|:...|      ||.:.    .|:: |:.:|....:::    .||:  ::
  Rat   454 GILKK---------SRQRESG------YYSSP----EPSESGELLDAGDVFVS----GDPM--EQ 493

  Fly   609 LSPLNEQSVAQMQCCQENATGECNEELQSYMQKRG--------GTQRHTVGCTEDLSVAHGSGAG 665
            .||              .|:|..:.  :..::..|        ||...|.|..:.|:..|.:...
  Rat   494 KSP--------------QASGRLHR--KGILKLNGKFSRTALEGTAPSTFGSLDQLASPHPTARA 542

  Fly   666 SQ-SQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNG 725
            |: |.|.:..|.:.......|.:.||.|..|......|::          |:.|.|.|..|
  Rat   543 SRPSGAVSEDSILSSESFDQLDLPERLPETPLRGCVSVDN----------LRRLEQPPSEG 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	118/251 (47%)
		UBA_SIK	335..380	CDD:270523	5/47 (11%)
Nuak2	NP_001007618.1	Protein Kinases, catalytic domain	53..307	CDD:473864	118/251 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..504		46/299 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..566		11/44 (25%)