DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and par-1

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	1169	Identity:	310/1169 - (26%)
Similarity:	459/1169 - (39%)	Gaps:	314/1169 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKV 67
            |:...|.......||.|..::....         .:|.|:|.|||||||||.||||.::.|..:|
  Fly   224 TSSAKGSPNMQMRSSAPMRWRATEE---------HIGKYKLIKTIGKGNFAKVKLAKHLPTGKEV 279

  Fly    68 AIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVAN 132
            ||||||||.||...|.|.|||:.|:|.|.||:|.:|::|:|::..:||:.|||..||:||:||.:
  Fly   280 AIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLH 344

  Fly   133 GRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTW 197
            |||||.||...|.|:||||.|||::.::||||||||:|||.::|||:|||||||.:..|:.|.|:
  Fly   345 GRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTF 409

  Fly   198 CGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMS 262
            ||||||||||:|||.:||||:.|:|||||:||.||.|:|||||.|:.||:.||:.||:||||:||
  Fly   410 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMS 474

  Fly   263 QECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSA 327
            .:||.|:|..||:.|.:|.:::.|:..:|::   ...:|.|....:.|.:...
  Fly   475 TDCENLLRKFLVLNPAKRASLETIMGDKWMN---MGFEEDELKPYIEPKADLA------------ 524

  Fly   328 SDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASL 392
              .|.:::::|..      |.....|..|:.:.|:|:::|.|.||..|......:..|.....||
  Fly   525 --DPKRIEALVAM------GYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSL 581

  Fly   393 AYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLA 457
            ............|......|..:.....:|..|...:..::.|.|
  Fly   582 RNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVG-------------------- 626

  Fly   458 RSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVP 522
                 |.||....|.|.|.|...|...:....|..|...::.:      :||
  Fly   627 -----PTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGS------NFK------------- 667

  Fly   523 YYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQ 587
                     :...:.:.|||:
  Fly   668 ---------RQNTIDSATIKE-------------------------------------------- 679

  Fly   588 MDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGC 652
                        .|..||.|...|   .|..|......:.|      |.|..:.|..|:
  Fly   680 ------------NTARLAAQNQRP---ASATQKMLTTADTT------LNSPAKPRTATK------ 717

  Fly   653 TEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKS 717
             .|.:..:.:.:|:....|..|:.:.::.:.    ||:..|||.|  ..:..|::   :...:||
  Fly   718 -YDPTNGNRTVSGTSGIIPRRSTTLYEKTSS----TEKTNVIPAE--TNLFDRLR---MASAVKS 772

  Fly   718 LSQSPPN----GTYPVG-------AALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVV 771
            ....|.|    .|:..|       .||....:.|.|...|.|      |.:...:..:.|.
  Fly   773 SRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHP------GRMSFFSKLSSRF---- 827

  Fly   772 HSKLPTVQEGATIGRYSPVRRASEGSKSQFQGPLQECQSLQK----------GIAQRNFLVAPSP 826
             ||.||:.:.|...|   |.|.:...|:  ..||...|.:||          ...||...|...
  Fly   828 -SKRPTIADEAAKPR---VLRFTWSMKT--TSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWC- 885

  Fly   827 PLLENSISLPGSPIHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRL----VKEQRVS-FEIA 886
                         :||.|.....:.    .:|||         ..|.||    |:.:|:| ..|.
  Fly   886 -------------VHGDPNTDSLVQ----WEIEV---------CKLPRLSLNGVRFKRISGTSIG 924

  Fly   887 NKIISTHVVPMDLAPLLGLAAHASSAAAVSGGHLD-----------------QSHFTHL------ 928
            .|.|::.:. .||...|....:..:|||.:....|                 .|..:.|
  Fly   925 FKNIASRIA-FDLKLXLNQTNNEGNAAATASRPTDPTDTMTTTNCRRPSNDSTSRLSELSLLCRS 988

  Fly   929 --QQQQQQQHMLSFSVSPLSMPQGGAVNA----SLTSAKQMFGQPICGYTQYQPMTLALQPQHQQ 987
              .||..|:...|      .:..||:.:.    ||.||.||          |.|.:.....|..:
  Fly   989 LTSQQGSQRRKKS------RLSTGGSEDQKKSNSLLSAFQM----------YSPFSSKENMQSSE 1037

  Fly   988 QLVGQFSSINLGASNSNSSSGCQSPVFSTSFSGSCSP-NPYL----PGAAGGSSPLHQITKGISG 1047
            ::.      :|...::........|:|:     ..|| ||.:    .|..||.:...::..|.||
  Fly  1038 EVE------DLHVIDTQPGHSVDVPLFA-----DFSPINPIMEEDAEGVEGGKTSEAKVISGGSG 1091

  Fly  1048 LST-----GCAGGS------------ITRGTSAASEGAAAAAAANQPLDLSMDVCGGVMDQQPT 1094
            ...     |..||:            |.|..:|.....|....|.:..|...........::||
  Fly  1092 QKVKGDGGGGGGGNRLKRNIKHTGSLIVRKLTAGRHNDADKKGAIRKKDKEQQEVADTDKERPT 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	147/251 (59%)
		S_TKc	41..292	CDD:214567	147/250 (59%)
		UBA_SIK	335..380	CDD:270523	11/44 (25%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	147/251 (59%)
		S_TKc	253..504	CDD:214567	147/250 (59%)
		UBA_MARK_Par1	525..563	CDD:270522	11/43 (26%)
		MARK1-3_C	839..936	CDD:213381	27/129 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840