DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and Smok2b

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001161385.1	Gene:	Smok2b / 236574	MGIID:	3037705	Length:	484	Species:	Mus musculus

Alignment Length:	478	Identity:	133/478 - (27%)
Similarity:	216/478 - (45%)	Gaps:	108/478 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYE 105
            |.:.:|||.|..:.|.||.:.:|.:.||:|:|.|   :|.:.|....|:.:|....||:|..|.:
Mouse     8 YVMLETIGHGGCSKVMLARHRLTGSHVAVKMIRK---SECWCNPVMSEVELLMMADHPNIISLLQ 69

  Fly   106 VMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVL 170
            |:|::..:||:.|......::.|:...|.::|.||..:|.||:||::|||.:|:||||||.:|::
Mouse    70 VIETKKKVYLIMELCEGKSLYQHIRNAGYLQEDEARALFKQLLSAMNYCHNQGIVHRDLKPDNIM 134

  Fly   171 LDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGA 235
            ::||..:|:.|||.....:.|..|..:||:.|::||||.....|||||.|:|:||||||.:|.|.
Mouse   135 VEKDGKVKIIDFGLGTQVKPGQKLNLFCGTYPFSAPEVLLSRPYDGPKIDVWTLGVVLYFMVTGK 199

  Fly   236 LPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQ 300
            :|||..:|.:|..:::.||:.:|..:|.|...||..::...|..|.|:.:::.|.|::|
Mouse   200 VPFDAASIQKLVRQILAGKYFVPSRLSVELRDLISLLMTANPKLRPTVAEVMVHPWVTE------ 258

  Fly   301 EQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNI 365
                      |||...        ....:..|...:..:...:...|..|..|..|:.:::|:..
Mouse   259 ----------GSGVFP--------DPCEEQMPLKPNPAIVKAMGYIGFQAQDIEDSLRQRKFNET 305

  Fly   366 YAIYNLLHDKLQQ-------------------------------RRRENQRLQHHASLAYSRSRK 399
            .|.|.||..::.:                               ||||.:    ..||..|.:|:
Mouse   306 MASYCLLKKQILKECDRPIRAQPMNPSVTPFPSLVDTSTFHLGLRRRETE----PTSLRLSANRQ 366

  Fly   400 TSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPV 464
            .|    |..||...|:   ||              .|.|..|                  :..|:
Mouse   367 MS----VCGRSTSKKR---DR--------------RFSWPSV------------------SGRPL 392

  Fly   465 NAQHLSAHAGGGVNGANTRRHTV 487
            :..|...|       .:||..:|
Mouse   393 HTTHTMDH-------THTRTRSV 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	94/250 (38%)
		S_TKc	41..292	CDD:214567	94/250 (38%)
		UBA_SIK	335..380	CDD:270523	9/75 (12%)
Smok2b	NP_001161385.1	STKc_AMPK-like	7..255	CDD:270905	94/249 (38%)
		S_TKc	8..256	CDD:214567	94/250 (38%)
		UBA_MARK_Par1	275..314	CDD:270522	9/38 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..400		16/82 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810