DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and Sik2

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_848825.2	Gene:	Sik2 / 235344	MGIID:	2445031	Length:	931	Species:	Mus musculus

Alignment Length:	1134	Identity:	316/1134 - (27%)
Similarity:	477/1134 - (42%)	Gaps:	334/1134 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHI 100
            :|||:|::|.|:||||||||||..:.:|||:||||||||:.|:...|.|.:||:.|:|.|.||||
Mouse    15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI 79

  Fly   101 TRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLK 165
            .:||:|||::||:|||||||.||||||:|..:||:.|.||.|.|.|::|||.|||.|.|||||||
Mouse    80 IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKVVHRDLK 144

  Fly   166 AENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYA 230
            |||:|||.:||||:|||||.|.::.|..|.||||||||||||||:|.:|:||:.||||:|||||.
Mouse   145 AENLLLDNNMNIKIADFGFGNFFKTGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYV 209

  Fly   231 LVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRW-LSE 294
            ||||||||||.|:..|:.||:.|:||||:|||::||.|||.|||::|.:|.:|.||.:|:| |.|
Mouse   210 LVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIE 274

  Fly   295 WQSEM-----QEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIA 354
            ...:.     ||||                :..|:|..::...:|     .|.|   |:......
Mouse   275 VPVQRPILYPQEQE----------------NEPSIGEFNEQVLRL-----MHSL---GIDQQKTV 315

  Fly   355 QSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLD 419
            :|:..:.:::..|||.||.::|:..|                            .|.||:|.
Mouse   316 ESLQNKSYNHFAAIYFLLVERLKSHR----------------------------SSFPVEQR--- 349

  Fly   420 RLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANTRR 484
                                                                     ::|...|.
Mouse   350 ---------------------------------------------------------LDGRQRRP 357

  Fly   485 HTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKP 549
            .|:....||..|.:.                   .||..:|.|:.::::..|
Mouse   358 STIAEQTVAKAQTVG-------------------LPVTLHPPNVRLMRSTLL------------- 390

  Fly   550 PVVMGASSFGRRASDGGANLHIYYPATGTVVGPA--QGQQMDTAGYYINPNCGTDPL-------A 605
            |......:|.             :|.:......|  :.:.:||.  .:| .|..||:       .
Mouse   391 PQASNVEAFS-------------FPTSSCQAEAAFMEEECVDTP--KVN-GCLLDPVPPVLVRKG 439

  Fly   606 VQEL-SPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVG-CTEDLSVAHGSGAGSQS 668
            .|.| |.:.|.|:.:....:..|..:.::..:::...|.|.:|||:. .|..|.|..|:|.
Mouse   440 CQSLPSSMMETSIDEGLETEGEAEEDPSQAFEAFQATRSGQRRHTLSEVTNQLVVMPGAGK---- 500

  Fly   669 QAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAAL 733
                           :.::::.|.      :..|:|..........|..|..||        :..
Mouse   501 ---------------MFSMSDNPS------LESVDSEYDMGSAQRDLNFLEDSP--------SLK 536

  Fly   734 PMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLP-TVQEGATIGRYSPVRRASEGS 797
            .:.::...||..:.|.::....:..:.|.::::  |..|::.| :.:||         ||||:.|
Mouse   537 DIMLANQPSPRMTSPFISLRPANPAMQALSSQK--REAHNRSPVSFREG---------RRASDTS 590

  Fly   798 KSQ----FQGPLQECQSLQKGIAQRN---------------FLVAPSPPLLENSISLPGSPIHGK 843
            .:|    |:..||.. :..|||.:.|               .|.:.:|.|.:.|.|.|...|..:
Mouse   591 LTQGIVAFRQHLQNL-ARTKGILELNKVQLLYEQMGSNADPTLTSTAPQLQDLSSSCPQEEISQQ 654

  Fly   844 ------------PGMGLQLALRR---GHDIEVPPEAIKNLMP---------------ALDRLVKE 878
                        |.:..|.:|..   .|.::.|     ||:|               :|::.::|
Mouse   655 QESVSSLSASMHPQLSPQQSLETQYLQHRLQKP-----NLLPKAQSPCPVYCKEPPRSLEQQLQE 714

  Fly   879 QRVS----FEIANKIISTHVVPMDLAPLLGLAAHASSAAAVSGGHLDQSHFTHLQQQQQQQHMLS 939
            .|:.    |......:..:...|.:|.    :::...:..::..|.:    |.|..||.....|:
Mouse   715 HRLQQKRLFLQKQSQLQAYFNQMQIAE----SSYPGPSQQLALPHQE----TPLTSQQPPSFSLT 771

  Fly   940 FSVSPLSMPQGGAVNASLTSAKQM-FGQPICGY--TQYQPMTLALQPQHQQQLVGQFSSINLGAS 1001
            .::||:..|          |::|| |...:..|  .|.||:.....||....|..|.....
Mouse   772 QALSPVLEP----------SSEQMQFSSFLSQYPEMQLQPLPSTPGPQAPPPLPSQLQQHQ---- 822

  Fly  1002 NSNSSSGCQSPVFSTSFSGSCSPNPYLPGAAGGS-------SPLHQITKGISGLSTGC------- 1052
                    |.|      .....|.|..||||..|       ..|...|..:......|
Mouse   823 --------QPP------PPPPPPPPQQPGAAPTSLQFSYQTCELPSTTSSVPNYPASCHYPVDGA 873

  Fly  1053 AGGSITRGTSAASEGAAAAAAANQPLDLS 1081
            ...::|......|.|....|::..||.||
Mouse   874 QQSNLTGADCPRSSGLQDTASSYDPLALS 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	161/252 (64%)
		S_TKc	41..292	CDD:214567	161/251 (64%)
		UBA_SIK	335..380	CDD:270523	10/44 (23%)
Sik2	NP_848825.2	STKc_SIK	19..271	CDD:270973	160/251 (64%)
		S_TKc	20..271	CDD:214567	160/250 (64%)
		UBA_SIK2	297..341	CDD:270592	11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..586		6/31 (19%)
		RK-rich region, required for cAMP responsiveness. /evidence=ECO:0000269\|PubMed:29211348	595..624		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..662		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..768		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..842		15/61 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810