Protein Alignment Sik3 and SIK2

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_056006.1
• Gene: SIK2 / 23235
• HGNCID: 21680
• Length: 926
• Species: Homo sapiens
• Alignment Length: 1173
• Identity: 332/1173 - (28%)
• Similarity: 487/1173 - (41%)
• Gaps: 369/1173 - (31%)

  Fly    36 LRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHI 100
            :|||:|::|.|:||||||||||..:.:|||:||||||||:.|:...|.|.:||:.|:|.|.||||
Human    15 VRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHI 79

  Fly   101 TRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLK 165
            .:||:|||::||:|||||||.||||||:|..:||:.|.||.|.|.|::|||.|||.|.:||||||
Human    80 IKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLK 144

  Fly   166 AENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYA 230
            |||:|||.:||||:|||||.|.::.|..|.||||||||||||||:|.:|:||:.||||:|||||.
Human   145 AENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYV 209

  Fly   231 LVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRW-LSE 294
            ||||||||||.|:..|:.||:.|:||||:|||::||.|||.|||::|.:|.||.||.:|:| |.|
Human   210 LVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIE 274

  Fly   295 WQSEM-----QEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIA 354
            ...:.     ||||                :..|:|..::...:|     .|.|   |:......
Human   275 VPVQRPVLYPQEQE----------------NEPSIGEFNEQVLRL-----MHSL---GIDQQKTI 315

  Fly   355 QSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQESLD 419
            :|:..:.:::..|||.||.::|:..|                            .|.||:|.
Human   316 ESLQNKSYNHFAAIYFLLVERLKSHR----------------------------SSFPVEQR--- 349

  Fly   420 RLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANTRR 484
                                                                     ::|...|.
Human   350 ---------------------------------------------------------LDGRQRRP 357

  Fly   485 HTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKP 549
            .|:....||..|.                            |.||:..:.|       :..||:.
Human   358 STIAEQTVAKAQT----------------------------VGLPVTMHSP-------NMRLLRS 387

  Fly   550 PVVMGASSFGRRASDGGANLHIY-YPATGTVVGPA--QGQQMDTAGYYINPNCGTDPL------- 604
            .::..||           |:..: :||:|.....|  :.:.:||.  .:| .|..||:
Human   388 ALLPQAS-----------NVEAFSFPASGCQAEAAFMEEECVDTP--KVN-GCLLDPVPPVLVRK 438

  Fly   605 AVQEL-SPLNEQSVAQMQCCQENATGECNEE----LQSYMQKRGGTQRHTVG-CTEDLSVAHGSG 663
            ..|.| |.:.|.|:.:    .....||..|:    .:::...|.|.:|||:. .|..|.|..|:|
Human   439 GCQSLPSNMMETSIDE----GLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAG 499

  Fly   664 -AGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESR-----MKRD--YLP--PTLKS- 717
             ..|.:.:|:..|                          |:|.     ::||  :|.  |:||.
Human   500 KIFSMNDSPSLDS--------------------------VDSEYDMGSVQRDLNFLEDNPSLKDI 538

  Fly   718 -LSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLP-TVQE 780
             |:..|                   ||..:.|.::....:..:.|.::::  |.||::.| :.:|
Human   539 MLANQP-------------------SPRMTSPFISLRPTNPAMQALSSQK--REVHNRSPVSFRE 582

  Fly   781 GATIGRYSPVRRASEGSKSQ----FQGPLQECQSLQKGIAQRNFLVAPSPPLLENSISLPGSPIH 841
            |         ||||:.|.:|    |:..||.. :..|||.:.|
Human   583 G---------RRASDTSLTQGIVAFRQHLQNL-ARTKGILELN---------------------- 615

  Fly   842 GKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRL--VKEQRVSFEIANKIISTHVVPMDLAP--- 901
                 .:||...     ::.|||..||.||..:|  :.......|::.:..|...:|..:.|
Human   616 -----KVQLLYE-----QIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLS 670

  Fly   902 ------------------LLGLAAHA----------SSAAAVSGGHLDQSHFTHLQQQQQQQHML 938
                              ||..|.:.          |....:....|.|......:|.|.|.:..
Human   671 PRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFN 735

  Fly   939 SFSVSPLSMPQGGAVNASLTSAKQMF---GQPICGYTQYQPMTLALQPQHQQQ----LVGQFSSI 996
            ...::..|.||   .:..|...:|..   .|....::..||::..|:|..:|.    .:.|:..:
Human   736 QMQIAESSYPQ---PSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEM 797

  Fly   997 NLGASNSNSSSGCQSPVFSTSFSGS------CSPNPYLPGAAGGSSPL---HQITKGISGLS--- 1049
            .|....|.|.... :|...|.....      ..|.|..||||  .:||   :|..:..|..|
Human   798 QLQPLPSTSGPRA-APPLPTQLQQQQPPPPPPPPPPRQPGAA--PAPLQFSYQTCELPSAASPAP 859

  Fly  1050 ----------TGCAGGSITRGTSAASEGAAAAAAANQPLDLSMDVCG-------GVMDQQPTDYA 1097
                      .|.....:|......|.|...|.::..||.|| ::.|       ..:|.|...|.
Human   860 DYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALS-ELPGLFDCEMLDAVDPQHNGYV 923

  Fly  1098 ATN 1100
            ..|
Human   924 LVN 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	161/252 (64%)
		S_TKc	41..292	CDD:214567	161/251 (64%)
		UBA_SIK	335..380	CDD:270523	10/44 (23%)
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	160/251 (64%)
		UBA_SIK2	297..341	CDD:270592	11/51 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	644..666		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	742..776		8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..896		20/97 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810