DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and Mark1

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001365805.1	Gene:	Mark1 / 226778	MGIID:	2664902	Length:	796	Species:	Mus musculus

Alignment Length:	712	Identity:	236/712 - (33%)
Similarity:	329/712 - (46%)	Gaps:	197/712 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PPTSSTPQNY-KVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTC 76
            |..||:.||. :..::...:.|:...:|.|.|:|||||||||.||||.:::|..:||:||||||.
Mouse    31 PAKSSSRQNLPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQ 95

  Fly    77 LNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAA 141
            ||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:|||||.||.
Mouse    96 LNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEAR 160

  Fly   142 RVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAP 206
            ..|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:|||||||||
Mouse   161 AKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAP 225

  Fly   207 EVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRN 271
            |:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||.:||.|::.
Mouse   226 ELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 290

  Fly   272 MLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLD- 335
            :||:.|.:|.:::||:|.||::....| :|.:.:                        |.|:||
Mouse   291 LLVLNPIKRGSLEQIMKDRWMNVGHEE-EELKPY------------------------SEPELDL 330

  Fly   336 ------SVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDK--------------LQQRR 380
                  .:::|     .|...|.|..::..|::|.:.|.|.||..|              |.||.
Mouse   331 SDAKRIDIMVT-----MGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGSLCQRS 390

  Fly   381 R-----ENQRLQHHASLAYSRS------------------------------------------- 397
            |     .|..||..|.|...||
Mouse   391 RPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWGK 455

  Fly   398 ----RKTSITTG-------------------------------VVDRSEPVKQESLDRLSPLSNA 427
                |..|.|.|                               :..|:..|.:.|.||.:.|.|.
Mouse   456 DTARRLGSTTVGSKSEVTASPLVGPDRKKSTASPSNNVYSGGSMARRNTYVCERSTDRYAALQNG 520

  Fly   428 NASS------SALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGG---------- 476
            ..||      |::....|.||                |..|....:|..:.:..|
Mouse   521 RDSSLTEMSASSMSSAGSTVA----------------SAGPSARPRHQKSMSTSGHPIKVTLPTI 569

  Fly   477 VNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTI 541
            .:|:...|    ||..|.....|:|:...|....|.:...|.          ........|...:
Mouse   570 KDGSEAYR----PGSAAQRVPAASPSAHSISASTPDRTRFPR----------GSSSRSTFHGEQL 620

  Fly   542 KDQHLLK---PPV----VMGASSFGRRASDGGANLHIYYPATGTVV--GPAQGQ---QMDTA 591
            :::....   ||.    ..||.:..||.:..|    |....|...|  .|::|:   :.|||
Mouse   621 RERRSAAYNGPPASPSHETGAFAHARRGTSTG----IISKITSKFVRRDPSEGEASGRADTA 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	153/251 (61%)
		S_TKc	41..292	CDD:214567	153/250 (61%)
		UBA_SIK	335..380	CDD:270523	14/65 (22%)
Mark1	NP_001365805.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		5/9 (56%)
		STKc_MARK	59..311	CDD:270974	153/251 (61%)
		UBA_like_SF	331..371	CDD:419673	10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..498		15/120 (13%)
		MARK1-3_C	697..794	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810