Protein Alignment Sik3 and Tssk1

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_033461.2
• Gene: Tssk1 / 22114
• MGIID: 1347557
• Length: 365
• Species: Mus musculus
• Alignment Length: 345
• Identity: 129/345 - (37%)
• Similarity: 191/345 - (55%)
• Gaps: 30/345 - (8%)

  Fly    35 LLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTF-REIAILKSLRHP 98
            |.|.||. :...:|:|::|.||.|.:...|..||:||||:.....::|.|.. |||.||..|.|.
Mouse     7 LKRRGYI-MGINLGEGSYAKVKSAYSERLKFNVAVKIIDRKKAPSDFLEKFLPREIEILAMLNHR 70

  Fly    99 HITRLYEVME-SQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHR 162
            .|.:.||:.| |...:|:|.|....|::.:.:...|.::|.:|.:.|.||.||:.|||...||||
Mouse    71 SIVKTYEIFETSDGKVYIVMELGVQGDLLEFIKTRGALQEDDARKKFHQLSSAIKYCHDLDVVHR 135

  Fly   163 DLKAENVLLDKDMNIKLADFGFSNHY---EEGATL--KTWCGSPPYAAPEVFQGLEYDGPKSDIW 222
            |||.||:|||||.||||:|||||...   :.|..:  ||:|||..||||||.||:.|.....|||
Mouse   136 DLKCENLLLDKDFNIKLSDFGFSKRCLRDDSGRLILSKTFCGSAAYAAPEVLQGIPYQPKVYDIW 200

  Fly   223 SLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPF----FMSQECEQLIRNMLVVEPDRRYTI 283
            ||||:||.:|||::|:|...|.::..  :..:.|:.|    .::.||:.||..||..:.:||..|
Mouse   201 SLGVILYIMVCGSMPYDDSNIKKMLR--IQKEHRVNFPRSKHLTGECKDLIYRMLQPDVNRRLHI 263

  Fly   284 KQIIKHRWL--------SEWQSEMQEQERFGDMS--PGSGTVSKSAS------TSSLGSASDSPP 332
            .:|:.|.|:        |...::..|..|..:.|  |..|...|||:      .:...:.|:|.|
Mouse   264 DEILNHCWVQPKARGLSSGAINKEGESSRATEPSWIPEPGADKKSATKLEPREEARSEARSESKP 328

  Fly   333 QLDSVVMTHMLQLPGLTADM 352
            |.|::.:....:..||::::
Mouse   329 QEDTLQVVRQSENVGLSSEL 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	109/262 (42%)
		UBA_SIK	335..380	CDD:270523	3/18 (17%)
Tssk1	NP_033461.2	STKc_TSSK1_2-like	10..271	CDD:271067	110/263 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..365		15/67 (22%)