DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and MARK2

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_011543091.1	Gene:	MARK2 / 2011	HGNCID:	3332	Length:	808	Species:	Homo sapiens

Alignment Length:	663	Identity:	227/663 - (34%)
Similarity:	323/663 - (48%)	Gaps:	151/663 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAI 69
            ||.|...:.|:|.:  |......|..|.|:...:|.|.|.|||||||||.||||.:|:|..:||:
Human    39 PTLGHLDSKPSSKS--NMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAV 101

  Fly    70 KIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGR 134
            ||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:||
Human   102 KIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR 166

  Fly   135 MKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCG 199
            |||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:||
Human   167 MKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCG 231

  Fly   200 SPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQE 264
            ||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||.:
Human   232 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTD 296

  Fly   265 CEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQ-----------EQERFGDMSPGSGTVSKS 318
            ||.|::..|::.|.:|.|::||:|.||::....:.:           :..|..::....|...:.
Human   297 CENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREE 361

  Fly   319 ASTSSLGSASDSPPQLDSVVMTHML------QLPGLT--------ADM---------------IA 354
            ...|.:|.      :.:.|:.|::|      :|.|.|        ||:               ::
Human   362 IQDSLVGQ------RYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVS 420

  Fly   355 QSVHEQRFDNIYA-----IYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVK 414
            .:..::||.:..|     ..|....|.|....||:|.:...    ...||.|.|..|.....|..
Human   421 ANPKQRRFSDQAAGPAIPTSNSYSKKTQSNNAENKRPEEDR----ESGRKASSTAKVPASPLPGL 481

  Fly   415 QESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPV--------------- 464
            :......:|.:|:..|:|.                       .||.:.|:
Human   482 ERKKTTPTPSTNSVLSTST-----------------------NRSRNSPLLERASLGQASIQNGK 523

  Fly   465 ------NAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPN----VPPIDFKCP-PQCSDPT 518
                  .::..:|.|...|:.|..|:|........|      ||    :||.:..|. |:.|...
Human   524 DSLTMPGSRASTASASAAVSAARPRQHQKSMSASVH------PNKASGLPPTESNCEVPRPSTAP 582

  Fly   519 QPVPYYPVNLPMLQNQPLHNLT----------------------------IKDQHLLK---PPVV 552
            |.||        :.:...||::                            ::||..|.   .|..
Human   583 QRVP--------VASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPAS 639

  Fly   553 MGASSFGRRASDG 565
            ....|.|||.:.|
Human   640 PSGHSQGRRGASG 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	154/251 (61%)
		S_TKc	41..292	CDD:214567	154/250 (62%)
		UBA_SIK	335..380	CDD:270523	14/78 (18%)
MARK2	XP_011543091.1	STKc_MARK	72..324	CDD:270974	154/251 (61%)
		S_TKc	73..324	CDD:214567	154/250 (62%)
		UBA_MARK2	342..383	CDD:270589	7/46 (15%)
		MARK2_C	709..807	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840