Protein Alignment Sik3 and kin-29

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_508493.1
• Gene: kin-29 / 180574
• WormBaseID: WBGene00002210
• Length: 822
• Species: Caenorhabditis elegans
• Alignment Length: 934
• Identity: 269/934 - (28%)
• Similarity: 407/934 - (43%)
• Gaps: 229/934 - (24%)

  Fly    35 LLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPH 99
            |.::|.|::.:.|||||||.|::|.:.:.|||||||.||.:.|:.|.|.|..||:.|:|.:.|||
 Worm    10 LEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPH 74

  Fly   100 ITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDL 164
            |.:.||:|...:|:|:|:||..:||:::.|:..||:.|..|.:.|::..|||.|.|.:|:|||||
 Worm    75 IVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDL 139

  Fly   165 KAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLY 229
            ||||:||.|:.|||:.||||||.......|.||||||||||||:..|..|||.|:||||:||:||
 Worm   140 KAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLY 204

  Fly   230 ALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSE 294
            .||.|..||...::.:||..|:.|..:||:::|.||...||.|||:.|.:||||:.:::|||: .
 Worm   205 ILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWM-H 268

  Fly   295 WQSEMQEQE--RFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLTADMIAQSV 357
            .:.::|:.:  :..:..|.|....:..||           :|:..:|..|.|....:.:.|..:|
 Worm   269 IRDDVQKNQAAQLLEAIPSSSIEIRQQST-----------KLNPTIMMFMQQHGKWSEEQIIDAV 322

  Fly   358 HEQRFDN-IYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSE-----PVKQE 416
            ..:.|:: |:|.|.||.||:::...|....:..     .|..:.||.:|..:..|     .:...
 Worm   323 LGRDFESPIFATYELLADKVKKGTLEGTGEEFP-----RRGSRGSILSGKANVDEQPLTPTISAH 382

  Fly   417 SLDRL---SPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGG--- 475
            .|.:|   ||..:::.||:      ||:..|           ...|:..|:|.:.......|
 Worm   383 QLAQLNLSSPDCDSDDSSN------SDLCDD-----------SPMSSMGPMNHERQFGTPHGLDI 430

  Fly   476 -GVNGANTRRHTVGPGDVAHEQALANPNV-----------------PPIDFKCPPQCSDPTQPVP 522
             | |....||||:    .|.|| |.:||:                 ||:.|  ||.   |.....
 Worm   431 IG-NRFENRRHTL----CASEQ-LLSPNMMGQFPPPNLLLNNFSMNPPLGF--PPM---PEGQAA 484

  Fly   523 YYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQ 587
            .:|  ||.| :.....:.|.|...:.|     .....||||.|...|...:..
 Worm   485 EFP--LPSL-HPAFATIPIADLSKMLP-----VPKSERRASAGETLLPTNFDL------------ 529

  Fly   588 MDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGC 652
                         |..||.....|::..:|              .||.:||:.|.|| :|:||.|
 Worm   530 -------------TQHLANLPAPPISFPTV--------------EEEGKSYLSKYGG-KRNTVHC 566

  Fly   653 TEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKS 717
                 :.:..|.|.|:..|      |.:||   ..|:.||           :..:..:..|:|.:
 Worm   567 -----LGNQLGGGIQNPIP------RYQRT---PYTKAPP-----------AERRSSWASPSLSA 606

  Fly   718 LSQSPPNGTYPVGAALPMGMS------KGLSPPHSLPLVAAAGGSVPLVAPN-------NRRIHR 769
            ..|:.....:.........|:      ||||...:...:...|.|  |..|.       ||:
 Worm   607 QQQNHLEKLFKQALQTNNDMTRLHKEFKGLSHGCAQSQITNEGSS--LACPQISITDEYNRQ--- 666

  Fly   770 VVHSKLPTVQEGATIGRYSPV----RRASE------------GSKSQFQG---PLQECQSLQKGI 815
              |:..|:...      :.||    :.|.|            .|.:.|.|   |.|..:|:...:
 Worm   667 --HNIAPSASS------FDPVSIFQKNAQEVVFGQRPATAIGFSSTSFSGMSTPEQTTRSIDDRV 723

  Fly   816 AQRNFLVAPSPPLLE---------NSISLPGSPIHG---KPGMG--LQLALRRGHDIEV---PPE 863
            ..    :..:.|..|         |.:.:|.|..|.   :|.:.  .:|:|..|.:|.|   |||
 Worm   724 RS----IVCTLPFTEVIDELKASLNILKIPFSESHEMVYEPQVTEMRRLSLPSGVEIGVAVLPPE 784

  Fly   864 AIKNLMPALDRLVKEQRVSFEIAN 887
                         .:..|.|.|.|
 Worm   785 -------------HKAHVEFAIIN 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	126/251 (50%)
		S_TKc	41..292	CDD:214567	126/250 (50%)
		UBA_SIK	335..380	CDD:270523	13/45 (29%)
kin-29	NP_508493.1	PKc_like	16..267	CDD:304357	126/250 (50%)
		S_TKc	16..267	CDD:214567	126/250 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010