DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik3 and par-1

DIOPT Version :9

Sequence 1:NP_001188969.1 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:NP_001122967.2 Gene:par-1 / 179912 WormBaseID:WBGene00003916 Length:1216 Species:Caenorhabditis elegans


Alignment Length:1547 Identity:403/1547 - (26%)
Similarity:578/1547 - (37%) Gaps:549/1547 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRH 97
            |:.:.||.|:|.|||||||||.||||.:::|..:|||||||||.||...|.|.|||:.|:|.|.|
 Worm    98 DQDVHVGKYKLLKTIGKGNFAKVKLAKHVITGHEVAIKIIDKTALNPSSLQKLFREVKIMKQLDH 162

  Fly    98 PHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHR 162
            |:|.:||:|||::..:|||.|||..||:||:|||:|||||.||...|.|:||||.|.|.:.::||
 Worm   163 PNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHR 227

  Fly   163 DLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVV 227
            ||||||:|||:|||||:|||||||.:..|..|.|:||||||||||:|.|.:||||:.|:|||||:
 Worm   228 DLKAENLLLDQDMNIKIADFGFSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVI 292

  Fly   228 LYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL 292
            ||.||.|:|||||:.:.||:.||:.||:||||:||.:||.|::..||:.|.||.::..|:|.||:
 Worm   293 LYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWM 357

  Fly   293 SEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASD------SPP--QLDSVVMTHMLQL--PG 347
                                          ::|...|      .||  |:|...:..::|:  .|
 Worm   358 ------------------------------NVGYEDDELKPFIEPPKDQIDEQRIEKLIQIFQLG 392

  Fly   348 LTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRREN----QRLQHHASLAYSRSRKTSITTGVVD 408
            .....|.:||.:::|::|:|.|.||.::........    |.|..|:|:..|.|.... ..||:.
 Worm   393 FNKAAILESVEKEKFEDIHATYLLLGERKSDMDASEITMAQSLLSHSSINVSSSLGQH-PAGVIT 456

  Fly   409 RSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHA 473
            |.....       |..|.::||.|              :|        :||:   ..|...|..|
 Worm   457 REHVTS-------SSASGSSASPS--------------RY--------SRSS---ATATGASITA 489

  Fly   474 GGGV-NGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLH 537
            |..: :.||.::         |:|:.|.|:                                   
 Worm   490 GSALASAANAQK---------HQQSSAAPS----------------------------------- 510

  Fly   538 NLTIKDQHLLKPPVVMGASSFGRRAS--DGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCG 600
                            ..||..||:|  |..|.     .|.||||                    
 Worm   511 ----------------SGSSSSRRSSQNDAAAT-----AAGGTVV-------------------- 534

  Fly   601 TDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAG 665
                                                     ..||:             ||   |
 Worm   535 -----------------------------------------MSGTR-------------HG---G 542

  Fly   666 SQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPP----NGT 726
            .|.:|..||   ||....||    :||...|.               .....::|.||    |.|
 Worm   543 VQMRAQPTS---RQATISLL----QPPSYKPS---------------SNTTQIAQIPPLFNRNST 585

  Fly   727 YPVGAALP----MGMSKGLSPPHSLPL--------------VAAAGGSVPLVAPN-------NRR 766
            ....||.|    .|..|...|...:||              |||..|.:|....:       |:.
 Worm   586 ATSSAAQPSTGITGTRKIADPKGRIPLNSTAVQGHRTATGAVAANNGGIPSHRDHAQQQQYMNQL 650

  Fly   767 IHRVVHSKL--PTVQEGATIGRYSPVRRASEGSKSQFQGPLQECQSLQKGIAQRNFLVAPSPPLL 829
            ....:.|||  .|...|.|....|     |..|.:....|||:..|        ....||:.|::
 Worm   651 TSSTMMSKLINKTPAAGGTAATSS-----SSSSSATSTAPLQKSGS--------QISHAPTEPVI 702

  Fly   830 ------ENSISLPGS-PIHGKPGMGLQLALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEI-- 885
                  .||.:..|: |:.|  |:|.|.:    ..::||.|   :...:.|:..::|:.|.|.  
 Worm   703 REDDDENNSENQNGNVPLIG--GVGPQTS----PAVQVPTE---DATSSSDKEQQQQKASSETPK 758

  Fly   886 ANKIISTHVVPMDLAPLLGLAAHASSAAAVSGGHLDQSHFTHLQQQQQQQHMLSFSVSPLSMPQG 950
            .:|....|..| .:.|...:.|..|...:.||.....:..|....|:.....:|.|.:..|...|
 Worm   759 ESKPSMIHQSP-SMPPSQMMTAMESLKLSESGQTGGPTVATGGPPQRATSQQMSRSATTNSANMG 822

  Fly   951 ---GAVNASLTSAKQMFGQPI---CGYTQYQP------MTLALQPQHQQQLVGQFSSINLGASNS 1003
               |...|:.::..|:.|.|.   ....||.|      .:.:..|.||.||..       .||.|
 Worm   823 ASSGGAAAAASATNQLSGAPSSTGASSQQYHPKAPSSSSSSSTNPPHQHQLTH-------NASFS 880

  Fly  1004 NSSSGCQSP------VFSTSFSGSCSPNPYLPGA-------------AGGSSPLHQITKGISGLS 1049
            .:.|..|.|      |.||....|.|.:.:....             .||.....:|.:....:|
 Worm   881 VTPSSYQIPTSTAVNVTSTGMPTSSSSSAFPRNTRNRQTFHGKTEKDKGGDDSSDEIGETPGNVS 945

  Fly  1050 TGCAGGS--------------ITRGTSAASEGAAAAAAANQP----LDLSMDVCGGVMDQQPTDY 1096
            .|..|.|              :||.:|        .|||:||    |..||.     |.|.|:..
 Worm   946 IGATGPSANNAEATIWSKLSKLTRRSS--------TAAAHQPRGSSLHHSMS-----MTQSPSQL 997

  Fly  1097 AA---TNWFMPTASYYDMKPLNLSPAQPVRVVPTPP-ASPNLCIIQEENGNGQMCHTISTGTPYA 1157
            ::   :|:..|........|:: :||.|....|.|. .||.:..:.:||..              
 Worm   998 SSRFTSNYVAPIVRSKPPAPVS-TPAAPSATAPIPVIVSPAVTKMLKENRR-------------- 1047

  Fly  1158 GCTGGITPQICLTDVQGSEITLVALSSDNSRDSEDSLEQHTPVMSLQGLIITEPSSDMPSITRGI 1222
                           :.|| ..:|:..|::|:|                 :|:|.|         
 Worm  1048 ---------------KLSE-EAMAIRRDHNRES-----------------MTQPVS--------- 1070

  Fly  1223 GRKASLDCDSGAGSHCPVASGSSHANQSQTQAQTEAQCRRGSDKSLGFSDDSLSNDSNNLSPCQE 1287
            ||                 :|:..|:|.|..|...|..|               ..|..::|   
 Worm  1071 GR-----------------AGTIGASQGQQTAAALAAIR---------------EQSGPIAP--- 1100

  Fly  1288 PSASSGFKSDSHSEMGDHTECGHLTPDSMCDSRRMSDEMCYEVPLPHECSNLDSTRILEMVKQTI 1352
                               ..|.:.|               .:|:........|.|....:|.| 
 Worm  1101 -------------------GAGQVAP---------------SLPIHEGDVKPRSLRFTWSMKTT- 1130

  Fly  1353 DSTMPPKGFVLHKGSISSEDSGAESRHSSASNASTSNPLAC-----EAASLLASHSGYGEPTTNL 1412
                         .|::.:|...|.|....:|       .|     |...:|..|   |:|.|: 
 Worm  1131 -------------SSLAPDDMMREIRKVLDAN-------GCDYEQRERYMILCVH---GDPNTD- 1171

  Fly  1413 SLEYSGGLQIELQVCEGRSRDHHGAGKGIKLRRISGDQFEY----GKICQQL 1460
            ||     :|.|::||:......:    |::.:||||....:    .||.|:|
 Worm  1172 SL-----VQWEMEVCKLPRLSLN----GVRFKRISGTSIGFKNIASKIAQEL 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_001188969.1 PKc_like 40..292 CDD:304357 152/251 (61%)
S_TKc 41..292 CDD:214567 152/250 (61%)
UBA_SIK 335..380 CDD:270523 12/46 (26%)
par-1NP_001122967.2 STKc_MARK 105..357 CDD:270974 152/251 (61%)
S_TKc 106..357 CDD:214567 152/250 (61%)
MARK1-3_C 1117..1214 CDD:213381 30/130 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5061
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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