Protein Alignment Sik3 and Sik1

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_034961.2
• Gene: Sik1 / 17691
• MGIID: 104754
• Length: 779
• Species: Mus musculus
• Alignment Length: 1063
• Identity: 315/1063 - (29%)
• Similarity: 447/1063 - (42%)
• Gaps: 338/1063 - (31%)

  Fly    24 VPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFRE 88
            |||.:.....|.||||:|::|:|:|||||||||||.:.||||:|||||||||.|:...|.|.:||
Mouse    10 VPSGTGQGQQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYRE 74

  Fly    89 IAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHY 153
            :.::|.|.||:|.:||:|||::.|:|:|||:|.|||:||:|.:||.:.|.||.:.|.|::|||.|
Mouse    75 VQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEY 139

  Fly   154 CHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPK 218
            ||...:||||||.||:|||.:|:||||||||.|.|:.|..|.||||||||||||||:|.||:||:
Mouse   140 CHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQ 204

  Fly   219 SDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTI 283
            .|:||||||||.||||:|||||..:..|:.||:.|:|||||||||:||.|||.||||:|.:|.||
Mouse   205 LDVWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITI 269

  Fly   284 KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGL 348
            .||.:|||:....:.:|:.:...||         ...||:||..::.        :..::|..|:
Mouse   270 AQIRQHRWMQADPTLLQQDDPAFDM---------QGYTSNLGDYNEQ--------VLGIMQALGI 317

  Fly   349 TADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPV 413
            ......:|:....:::..|||.||.::|::.|.           |...||.|         ..|.
Mouse   318 DRQRTIESLQNSSYNHFAAIYYLLLERLKEHRS-----------AQPSSRPT---------PAPT 362

  Fly   414 KQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVN 478
            :|..|                                       ||:|
Mouse   363 RQPQL---------------------------------------RSSD----------------- 371

  Fly   479 GANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIK- 542
                               |::..||.....|     ||.:|....|      |.|.|....::
Mouse   372 -------------------LSSLEVPQEILPC-----DPFRPSLLCP------QPQALAQSVLQA 406

  Fly   543 ----DQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDP 603
                |.|....|::                    :|             :||       || :..
Mouse   407 EIDCDLHSSLQPLL--------------------FP-------------LDT-------NC-SGV 430

  Fly   604 LAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGT--QRHTVGCTEDLSVAHGSGAGS 666
            ...:.:||   .|:......:|...|...||.|...:...|:  :|||:.   ::|
Mouse   431 FRHRSISP---SSLLDTAISEEARQGPSLEEEQEVQEPLPGSTGRRHTLA---EVS--------- 480

  Fly   667 QSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGT----- 726
                                 |...|:.||.||  |.|            |.:.||..||
Mouse   481 ---------------------THFSPLNPPCII--VSS------------SATASPSEGTSSDSC 510

  Fly   727 YPVGAAL-PMGMSKGLSPPHSLPLVAAAGGSVP--LVAPNNRRIHRVVHSKLPTVQEGATIGR-- 786
            .|..|:. |.|:..||:.|..|      |.|.|  |.:|     .....|..|.:|..|.:|.
Mouse   511 LPFSASEGPAGLGSGLATPGLL------GTSSPVRLASP-----FLGSQSATPVLQTQAGLGTAV 564

  Fly   787 YSPV-----RRASEGSKSQ----FQGPLQECQSLQKGIAQRNFLVAPSPPLLENSISLPG---SP 839
            ..||     ||||:.|.:|    |:..|:: .:..||....|.:...:..:.::|:..|.   |.
Mouse   565 LPPVSFQEGRRASDTSLTQGLKAFRQQLRK-NARTKGFLGLNKIKGLARQVCQSSVRTPRGGMST 628

  Fly   840 IH-GKPGMGLQ---LALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHVVPMDLA 900
            .| ..|..|||   .:.|.|..:             |:.::.:||
Mouse   629 FHTPAPSSGLQGCTTSNREGRSL-------------LEEVLHQQR-------------------- 660

  Fly   901 PLLGLAAHASSAAAVSGGHLDQSHFTHLQQQQQQQHMLSFSVSPLSMPQGGAVNASLTSAKQMFG 965
             ||.|..|:|:|||.||           .||..|...:.:.::|
Mouse   661 -LLQLQHHSSTAAASSG-----------CQQGPQLSPVPYVLAP--------------------- 692

  Fly   966 QPICGYTQYQPMTLALQPQHQQQLVGQFSSINLGASNSNSSSGCQS------PVFSTSFSGSCSP 1024
               |.......:.|...|..|..:....|:.:|..::.:.|:|..:      |...|..|..|.|
Mouse   693 ---CDSLLVSGIPLLPTPLLQAGMSPVASAAHLLDTHLHISAGPVALPTGPLPQCLTRLSPGCDP 754

  Fly  1025 NPYLPGAAGGSSPLHQITKGISG 1047
                .|...|...:..:|.|..|
Mouse   755 ----AGLPQGDCEMEDLTSGQRG 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	158/251 (63%)
		S_TKc	41..292	CDD:214567	158/250 (63%)
		UBA_SIK	335..380	CDD:270523	9/44 (20%)
Sik1	NP_034961.2	STKc_SIK	26..278	CDD:270973	158/251 (63%)
		S_TKc	27..278	CDD:214567	158/250 (63%)
		UBA_SIK1	300..349	CDD:270591	11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..375		11/119 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		6/22 (27%)
		RK-rich region	586..612		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..641		7/19 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810