DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sik3 and Mark3

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus

Alignment Length:	813	Identity:	256/813 - (31%)
Similarity:	362/813 - (44%)	Gaps:	217/813 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRH 97
            |:...:|.|.|.|||||||||.||||.:|:|..:|||||||||.||...|.|.|||:.|:|.|.|
Mouse    48 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNH 112

  Fly    98 PHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHR 162
            |:|.:|:||:|::..:||:.|||..||:||:|||:|||||.||...|.|:||||.|||::.:|||
Mouse   113 PNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVHR 177

  Fly   163 DLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVV 227
            ||||||:|||.|||||:|||||||.:..|:.|.|:||||||||||:|||.:||||:.|:|||||:
Mouse   178 DLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVI 242

  Fly   228 LYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWL 292
            ||.||.|:|||||:.:.||:.||:.||:||||:||.:||.|::..||:.|.:|.|::||:|.||:
Mouse   243 LYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPVKRGTLEQIMKDRWI 307

  Fly   293 SEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSV------VMTHMLQLPGLTAD 351
            :....| .|.:.|.:                        |:||..      :|..|    |.:.:
Mouse   308 NAGHEE-DELKPFVE------------------------PELDISDQKRIDIMVGM----GYSQE 343

  Fly   352 MIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQE 416
            .|.:|:.:.::|.|.|.|.||..|..:....:.....:.|||..|..
Mouse   344 EIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPN------------------ 390

  Fly   417 SLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGAN 481
                 |.|||:...|.             ...|.       ||.......:..|.|||
Mouse   391 -----SDLSNSTGQSP-------------HHKGQ-------RSVSSSQKQRRYSDHAG------- 423

  Fly   482 TRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHL 546
                               |.:|.:                   |..|........:..:|:..:
Mouse   424 -------------------PAIPSV-------------------VAYPKRSQTSTADSDLKEDGI 450

  Fly   547 LKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSP 611
              |.....:|:.|                 |..:.|| ...:..||   |||....|  .::.||
Mouse   451 --PSRKSSSSAVG-----------------GKGIAPA-SPMLGNAG---NPNKADIP--ERKKSP 490

  Fly   612 LNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTV---GCTEDLSVAHGSGAGSQSQAPTT 673
            ....|        ..|:|...........:|....||:|   |....|:......|...|...|:
Mouse   491 AVPSS--------NTASGGMTRRNTYVCSERCAADRHSVIQNGKENSLTEVFAYAASPASLCATS 547

  Fly   674 SSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLS----QSPPNGTYPVGAA-- 732
            :..:|.:|:..::.:..|.::.|.|..|.:          |.|:::    ::|...|:.:.:|
Mouse   548 TCRLRHQRSMSVSASGHPKMVLPPIDSEGD----------TFKAIAIPDERTPVASTHSISSATT 602

  Fly   733 -----LPMGMSKGLS---------------PPHSLPLVAAA--------GGSVPLVAPNNRRIHR 769
                 .|.|.:...:               ||.|..|...|        .||..|.:....::.|
Mouse   603 PDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTR 667

  Fly   770 VVHS-----KLPTVQEGATIGRYSPVRRASEGS 797
            ...|     :|||..|  ..|||       |||
Mouse   668 RNMSFRFIKRLPTEYE--RNGRY-------EGS 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	155/251 (62%)
		S_TKc	41..292	CDD:214567	155/250 (62%)
		UBA_SIK	335..380	CDD:270523	13/50 (26%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	155/251 (62%)
		UBA_MARK3_4	325..367	CDD:270590	12/45 (27%)
		MARK1-3_C	707..804	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840