Protein Alignment Sik3 and Mark2

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_006526704.1
• Gene: Mark2 / 13728
• MGIID: 99638
• Length: 851
• Species: Mus musculus
• Alignment Length: 804
• Identity: 264/804 - (32%)
• Similarity: 364/804 - (45%)
• Gaps: 185/804 - (23%)

  Fly     3 TTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKV 67
            |.||.|...:.|:|.:  |......|..|.|:...:|.|.|.|||||||||.||||.:|:|..:|
Mouse    27 TRPTLGHLDSKPSSKS--NMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEV 89

  Fly    68 AIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVAN 132
            |:||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:
Mouse    90 AVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAH 154

  Fly   133 GRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTW 197
            |||||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:
Mouse   155 GRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTF 219

  Fly   198 CGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMS 262
            ||||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||
Mouse   220 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 284

  Fly   263 QECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSA 327
            .:||.|::..|::.|.:|.|::||:|.||::....:                       ..|...
Mouse   285 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED-----------------------DELKPY 326

  Fly   328 SDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASL 392
            .:..|.......|.::...|.|.:.|..|:..||::.:.|.|.||..|..:...:...|:...|.
Mouse   327 VEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSA 391

  Fly   393 AYSRSRKTSITTGVVDRS---EPVKQESLDRLSP-LSNANASSSALGFGWSDVAVDLEKYGDFEL 453
            ..:.|...| .:..|.||   .|.::.|.|:..| :..:|:.|..
Mouse   392 DLTNSSAPS-PSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKK-------------------- 435

  Fly   454 ECLARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPT 518
               .:||    ||::.......|...::|.:....|             :|.:|.|       .|
Mouse   436 ---TQSN----NAENKRPEEETGRKASSTAKVPASP-------------LPGLDRK-------KT 473

  Fly   519 QPVP----------YYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSF---GRRASDGGANLH 570
            .|.|          ....|.|:|....|...:|::          |..|.   |.|||...|:
Mouse   474 TPAPSTNSVLSTSTNRSRNSPLLDRASLGQASIQN----------GKDSLTMPGSRASTASAS-- 526

  Fly   571 IYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEEL 635
                |..:...|.|.|:..:|..:.|...|..|.                         |.|.|:
Mouse   527 ----AAVSAARPRQHQKSMSASVHPNKASGLPPT-------------------------ESNCEV 562

  Fly   636 QSYMQKRGGT--QRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEI 698
                 .|..|  ||..|......:::..|||..::..|...|:......|.|
Mouse   563 -----PRPSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQL------------- 609

  Fly   699 IREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGGSV------ 757
                  |..||         .|:.|.|..|   |.|.|.|:|.         ..|.||:
Mouse   610 ------RQVRD---------QQNLPYGVTP---ASPSGHSQGR---------RGASGSIFSKFTS 647

  Fly   758 PLVAPN-NRRIHRVVHSKLPTVQE 780
            ..|..| :.|..|.....||..||
Mouse   648 KFVRRNLSFRFARRCRLSLPKSQE 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	154/251 (61%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
Mark2	XP_006526704.1	STKc_MARK	62..314	CDD:270974	154/251 (61%)
		UBA_MARK2	332..373	CDD:270589	11/40 (28%)
		MARK2_C	752..850	CDD:213386