DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and Mark2

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_006526704.1	Gene:	Mark2 / 13728	MGIID:	99638	Length:	851	Species:	Mus musculus

Alignment Length:	803	Identity:	264/803 - (32%)
Similarity:	364/803 - (45%)	Gaps:	183/803 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKV 67
            |.||.|...:.|:|.:  |......|..|.|:...:|.|.|.|||||||||.||||.:|:|..:|
Mouse    27 TRPTLGHLDSKPSSKS--NMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEV 89

  Fly    68 AIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVAN 132
            |:||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:
Mouse    90 AVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAH 154

  Fly   133 GRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTW 197
            |||||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:
Mouse   155 GRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTF 219

  Fly   198 CGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMS 262
            ||||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||
Mouse   220 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMS 284

  Fly   263 QECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSA 327
            .:||.|::..|::.|.:|.|::||:|.||::....:                       ..|...
Mouse   285 TDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHED-----------------------DELKPY 326

  Fly   328 SDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASL 392
            .:..|.......|.::...|.|.:.|..|:..||::.:.|.|.||..|..:...:...|:...|.
Mouse   327 VEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSA 391

  Fly   393 AYSRSRKTSITTGVVDRS---EPVKQESLDRLSP-LSNANASSSALGFGWSDVAVDLEKYGDFEL 453
            ..:.|...| .:..|.||   .|.::.|.|:..| :..:|:.|..
Mouse   392 DLTNSSAPS-PSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKK-------------------- 435

  Fly   454 ECLARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPT 518
               .:||    ||::.......|...::|.:....|             :|.:|.|       .|
Mouse   436 ---TQSN----NAENKRPEEETGRKASSTAKVPASP-------------LPGLDRK-------KT 473

  Fly   519 QPVP----------YYPVNLPMLQNQPLHNLTIKD--QHLLKPPVVMGASSFGRRASDGGANLHI 571
            .|.|          ....|.|:|....|...:|::  ..|..|         |.|||...|:
Mouse   474 TPAPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMP---------GSRASTASAS--- 526

  Fly   572 YYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQ 636
               |..:...|.|.|:..:|..:.|...|..|.                         |.|.|:
Mouse   527 ---AAVSAARPRQHQKSMSASVHPNKASGLPPT-------------------------ESNCEV- 562

  Fly   637 SYMQKRGGT--QRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEII 699
                .|..|  ||..|......:::..|||..::..|...|:......|.|
Mouse   563 ----PRPSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQL-------------- 609

  Fly   700 REVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGGSV------P 758
                 |..||         .|:.|.|..|   |.|.|.|:|.         ..|.||:      .
Mouse   610 -----RQVRD---------QQNLPYGVTP---ASPSGHSQGR---------RGASGSIFSKFTSK 648

  Fly   759 LVAPN-NRRIHRVVHSKLPTVQE 780
            .|..| :.|..|.....||..||
Mouse   649 FVRRNLSFRFARRCRLSLPKSQE 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	154/251 (61%)
		S_TKc	41..292	CDD:214567	154/250 (62%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
Mark2	XP_006526704.1	STKc_MARK	62..314	CDD:270974	154/251 (61%)
		UBA_MARK2	332..373	CDD:270589	11/40 (28%)
		MARK2_C	752..850	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840