Protein Alignment Sik3 and sff

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_061515877.1
• Gene: sff / 1280445
• VectorBaseID: AGAMI1_008093
• Length: 809
• Species: Anopheles gambiae
• Alignment Length: 860
• Identity: 225/860 - (26%)
• Similarity: 361/860 - (41%)
• Gaps: 208/860 - (24%)

  Fly    25 PSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREI 89
            ||::....:....||.|.||:|:|||...:|||..:.|...|||||||::..|:|..|.|..|||
Mosquito    12 PSSASTGTEGHQYVGPYRLERTLGKGQTGLVKLGVHCVLGKKVAIKIINREKLSESVLMKVEREI 76

  Fly    90 AILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYC 154
            ||:|.:.|||:..|.:|.|::..:|||.|:...||:||:||..||:...||.:.|.|::||:.:|
Mosquito    77 AIMKLIDHPHVLGLTDVYENRKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFC 141

  Fly   155 HRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKS 219
            |...:.|||||.||:|||...|||:||||.::....|:.|:|.||||.||.|||.:|.:|||.::
Mosquito   142 HSHSICHRDLKPENLLLDDKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRRA 206

  Fly   220 DIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIK 284
            |:||.||:||||:.||||||...:.:|..:|..|.|.||.|:..:|:.|::.|:.|.|::|.|:.
Mosquito   207 DVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLKGMIEVNPEKRLTLA 271

  Fly   285 QIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLDSVVMTHMLQLPGLT 349
            :|.||.|::               :.|.|.:....            |.:: ||.||:  :|..:
Mosquito   272 EINKHPWVT---------------AGGKGELELEL------------PMME-VVQTHV--IPNAS 306

  Fly   350 A------------------DMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSR 396
            |                  |.:.|.:.....:....||.||.|    |:|....::....:...|
Mosquito   307 AVDTDVLNAICSLGCFKEKDKLIQELLSPHHNTEKVIYFLLLD----RKRRRPAIEDEEDVLRPR 367

  Fly   397 SRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSND 461
            :       .:::.::|.::. ||    ....|.|||.             .||..       |..
Mosquito   368 N-------DIIEIADPPRKR-LD----TCRINGSSSL-------------SYGQI-------SEG 400

  Fly   462 PPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALA-----NPNVPPIDFKCPPQCSDPTQPV 521
            .|:                .:||.|...|..:|..:.:     :|:..|:.   ......||:.|
Mosquito   401 SPL----------------TSRRQTFNNGHRSHSGSTSGGSRRSPSSVPLS---RSSYQSPTRGV 446

  Fly   522 PYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATGTVVGPAQGQ 586
               .||    .:|||:.        |.||....|:|          |.|..|
Mosquito   447 ---VVN----SSQPLNQ--------LHPPSSPNAAS----------NRHSNY------------- 473

  Fly   587 QMDTAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTVG 651
                     :|...|....:...||::.::         |:.......|.|        :..:..
Mosquito   474 ---------SPRSSTKSQVIDSSSPVHHRA---------NSGPAVTVGLFS--------ETDSNN 512

  Fly   652 CTEDLSVAHGS---GAGSQSQAPTTSSNM-RQRRTGL--------------LTVTERPPVIPPEI 698
            .|..::...||   |:..|.||.||.|.: :.|.|.:              :.::.....:.||.
Mosquito   513 MTSSINAIPGSPILGSPQQLQAVTTGSQLWKTRLTNIKNSFLGSPKFHRRKMQISTEEVHLTPES 577

  Fly   699 IREVESRMKRDYLPPTLKS-----LSQSPPNGT---YPVGAALPM-GMSKGLSPPHSLPLVAAAG 754
            ..|:..:.....|..|.|.     |.:..|..|   :.:.|.|.| .:|..:..|.|..:....|
Mosquito   578 SPELTKKSWFGNLMTTEKDETFTVLVKGKPLATVKAHLIHAFLSMTELSHSVLSPMSFRVEYKRG 642

  Fly   755 GSVPLVAPNNRRIHRVVHSKLPTVQEGATIG--RYSPVRRASEGSKSQFQGPLQECQSLQKGIAQ 817
            |:.|.:...:.||...::    |:.:...:|  .::.......|:..:|:   :.|:.:|..:..
Mosquito   643 GTGPTMFQRHVRIQVDIN----TICKQGDVGDMLFAITFTLISGNIRRFR---RICEHIQAQVCS 700

  Fly   818 RNFLVAPSPPLLENS 832
            :.:....||....|:
Mosquito   701 KRYPALSSPTNQHNN 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	119/251 (47%)
		UBA_SIK	335..380	CDD:270523	13/62 (21%)
sff	XP_061515877.1	None