DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik3 and AMPKalpha

DIOPT Version :10

Sequence 1:NP_611361.4 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:XP_312237.4 Gene:AMPKalpha / 1273276 VectorBaseID:AGAMI1_005037 Length:565 Species:Anopheles gambiae


Alignment Length:527 Identity:171/527 - (32%)
Similarity:262/527 - (49%) Gaps:125/527 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNE-EYLNKTFREIAILKSLRHP 98
            |:::|:|.|..|:|.|:|..||:..:.|||.|||:||:::..:.. :.:.|..|||..||..|||
Mosquito    15 LVKIGHYILGATLGTGSFGKVKIGEHQVTKHKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHP 79

  Fly    99 HITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRD 163
            ||.:||:|:.:.:.|:::.||...||:||::|.||:::|.||.|.|.|::|.|.||||..:||||
Mosquito    80 HIIKLYQVISTPTDIFMIMEYVSGGELFDYIVKNGKLQESEARRFFQQIISGVDYCHRHMIVHRD 144

  Fly   164 LKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVL 228
            ||.||:|||.:.::|:||||.||...:|..|:|.||||.||||||..|..|.||:.||||.||:|
Mosquito   145 LKPENLLLDHNRHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLYAGPEVDIWSCGVIL 209

  Fly   229 YALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLS 293
            |||:||.||||.:.:..|..::..|.|.||.:::::...|:..||.|:|.:|.|:::|.||.|  
Mosquito   210 YALLCGTLPFDDEHVPTLFRKIKSGVFPIPEYLNKQVVSLLCQMLQVDPLKRATVEEIKKHEW-- 272

  Fly   294 EWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQLD-SVVMTHMLQLPGLTADMIAQSV 357
             :|.::...     :.|                   ||.:.| |||.|:.::   ...:..:...
Mosquito   273 -FQKDLPAY-----LFP-------------------SPVEQDSSVVDTNAIR---EVCEKFSVKE 309

  Fly   358 HEQRFDNIYAIYNLL-----HDKLQQRRRENQRLQHHASLAYSRSRKTSITTGVVDRSEPVKQES 417
            ||        ::|.|     ||:|              ::||..         ::|         
Mosquito   310 HE--------VHNALLSGDPHDQL--------------AIAYHL---------IID--------- 334

  Fly   418 LDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANT 482
                    |...:..|       ...:|:::      .:|.|..||               ||::
Mosquito   335 --------NKRIADEA-------AKAELKEF------YVAGSPPPP---------------GADS 363

  Fly   483 RRHT-VGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHL 546
            :..| :|||.:|..|| ..|:.|   ||.|....:...|:...||.  ..||.|:..|:     .
Mosquito   364 KFGTPLGPGSIAPTQA-GTPSEP---FKSPSIHPERIAPLRERPVT--AAQNMPVPTLS-----T 417

  Fly   547 LKPPVVM 553
            :.|..||
Mosquito   418 MSPSAVM 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_611361.4 Protein Kinases, catalytic domain 40..292 CDD:473864 118/252 (47%)
UBA_SIK 335..380 CDD:270523 12/50 (24%)
AMPKalphaXP_312237.4 STKc_AMPK_alpha 18..273 CDD:270981 120/257 (47%)
UBA_AID_AMPKalpha 290..354 CDD:270521 17/127 (13%)
AMPKA_C 436..563 CDD:213378
Blue background indicates that the domain is not in the aligned region.

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