Protein Alignment Sik3 and Mark1

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_038946210.1
• Gene: Mark1 / 117016
• RGDID: 619882
• Length: 794
• Species: Rattus norvegicus
• Alignment Length: 848
• Identity: 261/848 - (30%)
• Similarity: 385/848 - (45%)
• Gaps: 225/848 - (26%)

  Fly    13 PPT-SSTPQNYKVP---STSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIID 73
            ||| ||:.||  :|   ::...:.|:...:|.|.|:|||||||||.||||.:::|..:||:||||
  Rat    30 PPTKSSSRQN--IPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIID 92

  Fly    74 KTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEP 138
            ||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:|||.|||..||:||:|||:|||||.
  Rat    93 KTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEK 157

  Fly   139 EAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPY 203
            ||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|:||||||
  Rat   158 EARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPY 222

  Fly   204 AAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQL 268
            ||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:|:||:||.:||.|
  Rat   223 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENL 287

  Fly   269 IRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQ 333
            ::.:||:.|.:|.:::||:|.||::....| :|.:.:                        |.|:
  Rat   288 LKKLLVLNPIKRGSLEQIMKDRWMNVGHEE-EELKPY------------------------SEPE 327

  Fly   334 LD-------SVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHAS 391
            ||       .:::|     .|...|.|..::..|::|.:.|.|.||       .|:....:...|
  Rat   328 LDLNDAKRIDIMVT-----MGFARDEINDALVSQKYDEVMATYILL-------GRKPPEFEGGES 380

  Fly   392 LAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECL 456
            |:         :..:..||.|        .|.|:|:...|.|                  .|: :
  Rat   381 LS---------SGNLCQRSRP--------SSDLNNSTLQSPA------------------HLK-V 409

  Fly   457 ARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPP-IDFKCPPQCSDPTQP 520
            .||.......:..|.|||                          |::|| :.:...||.:
  Rat   410 QRSISANQKQRRFSDHAG--------------------------PSIPPAVSYTKRPQAN----- 443

  Fly   521 VPYYPVNLPMLQNQP--------LHNLTIKDQHLLKPPVVMGASSFGRRASDGGANLHIYYPATG 577
                  ::...|.:.        |.:.|:..:..:....::|..   |:.|..|.:.::|
  Rat   444 ------SVESEQKEEWDKDTARRLGSTTVGSKSEVTASPLVGPD---RKKSSAGPSNNVY----- 494

  Fly   578 TVVGPAQGQQMDTAGYYINPNC--GTDPLAVQELSPLNEQSVAQMQCCQENATG----ECNEELQ 636
                  .|..|.....|:   |  .||..|.  |....:.|:.:|.....::||    ......:
  Rat   495 ------SGGSMTRRNTYV---CERSTDRYAA--LQNGRDSSLTEMSASSMSSTGSTVASAGPSAR 548

  Fly   637 SYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIRE 701
            ...||...|..|.:..|                .||........|.|  :..:|.|.
  Rat   549 PRHQKSMSTSGHPIKVT----------------LPTIKDGSEAYRPG--STAQRVPA-------- 587

  Fly   702 VESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSK--------------------GLSPPHS 746
                     ..|:..|:|.|.|:.|     ..|.|.|.                    ..||.|.
  Rat   588 ---------ASPSAHSISASTPDRT-----RFPRGSSSRSTFHGEQLRERRSAAYSGPPASPSHD 638

  Fly   747 LPLVAAA--GGSVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASEGSKSQFQGPLQECQ 809
            ...:|.|  |.|..:::....:..|    :.|:  ||...||....|.:|...|.:.:|...:.:
  Rat   639 TAALAHARRGTSTGIISKITSKFVR----RDPS--EGEASGRTDTARGSSGEPKDKEEGKEAKPR 697

  Fly   810 SLQ 812
            ||:
  Rat   698 SLR 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	152/251 (61%)
		S_TKc	41..292	CDD:214567	152/250 (61%)
		UBA_SIK	335..380	CDD:270523	11/51 (22%)
Mark1	XP_038946210.1	STKc_MARK	59..311	CDD:270974	152/251 (61%)
		UBA_MARK1	331..371	CDD:270588	10/51 (20%)
		MARK1-3_C	695..792	CDD:213381	2/6 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810