Protein Alignment Sik3 and SIK1B

DIOPT Version :9

• Sequence 1: NP_001188969.1
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: NP_001307572.1
• Gene: SIK1B / 102724428
• -ID: -
• Length: 783
• Species: Homo sapiens
• Alignment Length: 857
• Identity: 289/857 - (33%)
• Similarity: 385/857 - (44%)
• Gaps: 224/857 - (26%)

  Fly    28 SKISVD---------KLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLN 83
            |:.|.|         |.||||:|::|:|:|||||||||||.:.||||:|||||||||.|:...|.
Human     5 SEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE 69

  Fly    84 KTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLV 148
            |.:||:.::|.|.||||.:||:|||::.|:|:|||:|.|||:||:|.:||.:.|.||.:.|.|::
Human    70 KIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQIL 134

  Fly   149 SAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLE 213
            |||.|||...:||||||.||:|||.:|:||||||||.|.|:.|..|.||||||||||||||:|.|
Human   135 SAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKE 199

  Fly   214 YDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPD 278
            |:||:.||||||||||.||||:|||||..:..|:.||:.|:|||||||||:||.|||.||||:|.
Human   200 YEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPA 264

  Fly   279 RRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSAS--TSSLGSASDSPPQLDSVVMTH 341
            ||.||.||.:|||:           |.....||....:.||.  ||:||...:.        ...
Human   265 RRITIAQIRQHRWM-----------RAEPCLPGPACPAFSAHSYTSNLGDYDEQ--------ALG 310

  Fly   342 MLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRKTSITTGV 406
            ::|..|:......:|:....:::..|||.||.::|::.|  |.:..........|.|.:.: :|:
Human   311 IMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYR--NAQCARPGPARQPRPRSSDL-SGL 372

  Fly   407 VDRSEPVKQESLDR-------LSPLSNANASSSALGFGWSDVAVDLEKYGDFELE---------- 454
                 .|.||.|..       |.|.......|.            |:...|.||:
Human   373 -----EVPQEGLSTDPFRPALLCPQPQTLVQSV------------LQAEMDCELQSSLQWPLFFP 420

  Fly   455 ----CLARSNDPPVNAQHL-------SAHAGGGVN----------GANTRRHTVGPGDVAHEQAL 498
                |.......||:...|       .|..|.|:.          .:..||||     :|.....
Human   421 VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHT-----LAEVSTR 480

  Fly   499 ANPNVPPIDFKCPPQCSDPTQ----------------------PVPY------YPVNL--PMLQN 533
            .:|...|.....|...:.|.:                      |...      .||.|  |.|.:
Human   481 LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGS 545

  Fly   534 Q---PLHNLTIKDQHLLKPPVVMGAS-SFGRRASDGGANLHIYYPATGTVVG-PAQGQQM----D 589
            |   |:    ::.|..|...|::..| ..||||||           |....| .|..||:    .
Human   546 QSATPV----LQAQGGLGGAVLLPVSFQEGRRASD-----------TSLTQGLKAFRQQLRKTTR 595

  Fly   590 TAGYYINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGG-TQRHTVGCT 653
            |.|:.                .||:......|.||..|:          ...||| :..|....:
Human   596 TKGFL----------------GLNKIKGLARQVCQVPAS----------RASRGGLSPFHAPAQS 634

  Fly   654 EDLSVAHGSGAGSQSQAPTTSSNMRQRRTGLLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSL 718
            ..|   ||..|||:.........:.|:|  ||.:...|...|                     ..
Human   635 PGL---HGGAAGSREGWSLLEEVLEQQR--LLQLQHHPAAAP---------------------GC 673

  Fly   719 SQSPPNGTYPVGAALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGAT 783
            ||:|.....|...|...|  .|.:|   ||......| :||:.|             |.:|.||
Human   674 SQAPQPAPAPFVIAPCDG--PGAAP---LPSTLLTSG-LPLLPP-------------PLLQTGA- 718

  Fly   784 IGRYSPVRRASE 795
                |||..|::
Human   719 ----SPVASAAQ 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	161/251 (64%)
		S_TKc	41..292	CDD:214567	161/250 (64%)
		UBA_SIK	335..380	CDD:270523	9/44 (20%)
SIK1B	NP_001307572.1	STKc_SIK	26..278	CDD:270973	161/251 (64%)
		UBA_SIK1	300..349	CDD:270591	11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		4/29 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		7/32 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810