DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sik3 and sik3

DIOPT Version :9

Sequence 1:NP_001188969.1 Gene:Sik3 / 37152 FlyBaseID:FBgn0262103 Length:1471 Species:Drosophila melanogaster
Sequence 2:XP_004916140.2 Gene:sik3 / 100492939 XenbaseID:XB-GENE-6042192 Length:1284 Species:Xenopus tropicalis


Alignment Length:1603 Identity:461/1603 - (28%)
Similarity:653/1603 - (40%) Gaps:505/1603 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MATTPTAGPAA-APPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTK 64
            ||.|...||.. .||..:.|                .|:||||:::||||||||||||||:|||:
 Frog     1 MAATVPGGPGTQLPPHRAAP----------------ARIGYYEIDRTIGKGNFAVVKLATHIVTR 49

  Fly    65 TKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHL 129
            .||||||||||.|:||.|.|.|||:.|:|.|.||||.|||:|||::.|||||||||..|||||||
 Frog    50 AKVAIKIIDKTKLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHL 114

  Fly   130 VANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATL 194
            ||:|||.|.||.:.|.|:|:|||:||.|.:|||||||||:|||.::|||:|||||||.:..|..|
 Frog   115 VAHGRMAEKEARKKFKQIVAAVHFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNRFTPGQLL 179

  Fly   195 KTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPF 259
            |||||||||||||:|:|.||||||.||||||||||.||||||||||.|:..|::||:.|||||||
 Frog   180 KTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPF 244

  Fly   260 FMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSL 324
            |||.|||.|||:|||:||.:|.:::||.||:|:.:.:.:: |.||.            .|....:
 Frog   245 FMSTECEHLIRHMLVLEPSKRLSMEQICKHKWMCQGEQDL-EFERL------------IAECQHV 296

  Fly   325 GSASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHH 389
            .......|..:.|::| |::: ||..:...||:....:|:..|||:||.|:|  :|.:..||.  
 Frog   297 KLERQRDPLNEQVLLT-MVEM-GLDRERTLQSLRTDAYDHYSAIYSLLCDRL--KRHKTLRLP-- 355

  Fly   390 ASLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAV------DLEKY 448
                                ::|....::...:|...|:|:|:.:......|.:      .:|..
 Frog   356 --------------------TQPSAPRTVSYSTPSVQADAASNTVSINVPQVQLINPENQIVETN 400

  Fly   449 GDFELEC-LARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALAN-----PNVPPID 507
            |...|:. .|....|...|::||           .||||||..|..:|.....     |..|.: 
 Frog   401 GTMTLDSDEAEEPSPEALARYLS-----------MRRHTVGVPDTHNESGTDELQKIFPGFPRV- 453

  Fly   508 FKCPPQCSDPTQPVPYYPVN---------LPMLQNQPLHNLTIKDQHLLKPPVVM---GASSFGR 560
                      ||.:|:.||.         |||   .|..:|..|:|.||:||.:.   |....||
 Frog   454 ----------TQQIPFLPVTQNTNVLHTLLPM---PPSAHLEYKEQSLLQPPTLQLLNGMGPLGR 505

  Fly   561 RASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPL-----AVQELSPLNEQSVAQM 620
            ||||||||:.::                  |...:....|..||     .|..::|::|      
 Frog   506 RASDGGANIQMH------------------AQLLLKRPRGPSPLVTMATTVTAVTPVDE------ 546

  Fly   621 QCCQENATGECNEE-LQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTGL 684
                |::.||.::| :|.|:..|  |:|||:..|                :||..          
 Frog   547 ----ESSDGEPDQEAVQRYLANR--TKRHTLAMT----------------SPTAE---------- 579

  Fly   685 LTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLPL 749
                     ||||:.|::..:              |:..|..:               |||    
 Frog   580 ---------IPPELQRQLGQQ--------------QAFRNRAW---------------PPH---- 602

  Fly   750 VAAAGGSVPLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRASEGSKS--QFQGPL------- 805
                      :||:   :||.::....|:...|.  |:|||||.|:|:.:  .|:..|       
 Frog   603 ----------LAPD---LHRSMYKDSNTLHLPAE--RFSPVRRFSDGAATIQAFKAHLEKMGNQN 652

  Fly   806 -------QECQSLQK--GI--------------------AQRNFL----------VAPSPPLLEN 831
                   |||:.|||  |:                    .|.:.|          ..|||||..:
 Frog   653 SSIKQLQQECEQLQKMYGVHMDERTLEHTQQQHVMYQHEHQHHLLQQQIQDCIRPAQPSPPLQSS 717

  Fly   832 SIS-------------------LPGSP--------------------------IHGK------PG 845
            |::                   .|.||                          .||.      ||
 Frog   718 SMTPASENQPALLTHQLQRLRIQPSSPPPNPASNHLFRQPNSSPPPSSSAMLQTHGATSSSQYPG 782

  Fly   846 MGLQLALRRGHDIEVPPEAIKNLMPALDRLVKEQRVSFEIANKIISTHVVPMDLAPLLGLAAHAS 910
            |....::.:......||.::     ||.|:..:|:.|.:.:.:.::..|            ..||
 Frog   783 MPTHSSIYQPSSTGSPPPSM-----ALPRMSIQQQQSQQQSPQQVTIQV------------QEAS 830

  Fly   911 SAAAVSGGHLDQSHFTHLQQQQQQQHMLS---FSVSPLSMPQGGAVNASLTSAKQMFGQPICGY- 971
            .....|.|........|:|.||:...|.|   :|..||| .|..|.||.:.|.......|...| 
 Frog   831 DLPGASRGMPIIPCANHIQMQQRASLMSSMGNYSHRPLS-KQLSADNAEVHSLNMAHFSPSTNYD 894

  Fly   972 -TQYQPMTLALQPQHQQQLVGQFSSINLGASNSNSSSGC----------QSPVFSTSFSGS---- 1021
             |...|...|.||:....:   ::|...|...|..::..          |.|.|||:...:    
 Frog   895 QTHLHPHVFAEQPRPPPAV---YTSTGSGYGPSGGTAAYSQALKVPQMEQYPGFSTTSQQNYPSS 956

  Fly  1022 ------CSPNP--------YLPGAAGG-SSPLHQITKGISGLSTGCAGGSITRGTSAASEGAAAA 1071
                  .||.|        .||....| .||.|.:|           |.:..|...|        
 Frog   957 SLQQALLSPTPGTYTRHHQQLPHMLQGLLSPRHSLT-----------GHTDVRLPPA-------- 1002

  Fly  1072 AAANQPLDLSMDVCGGVMDQQPTDYAATNWFMPTASYYDMKPLNL---SPAQP----VRVVPTPP 1129
                       |....:...|.........|....|..|  |.||   |.::|    :::.|...
 Frog  1003 -----------DFMQLIKQHQQQQQELNELFNQQLSQGD--PGNLPYQSASEPYHHLLQIHPASA 1054

  Fly  1130 ASPNLCIIQEENGNGQMCHTISTGTPYAG-----CTGGITPQICL----TDVQGSEITLVALSSD 1185
            |:|      :...:..|.|:.|....::|     ..|.....:|.    |....:|..|..|:  
 Frog  1055 ATP------DSRYHPIMLHSESMEEDFSGEGQKESEGETVRSLCKPCQETRHGDTESLLGTLA-- 1111

  Fly  1186 NSRDSEDSLEQHTPVMSLQGLIITEPSSDMPSITRGIGRKAS----LDC-DSGAGSHCPVASGSS 1245
             .::.|..::|:....|...   |:.:|..|..|.....:||    :|. |.....:.|..|.|.
 Frog  1112 -LKEQELGVQQYKTQTSYNR---TKSASREPGPTANCMDRASPPHVMDVPDHNGIPYPPRPSSSE 1172

  Fly  1246 HANQSQTQAQTEAQCRRGSDKSLGFSDDSLSNDSNNLSPCQEPSASSGFKSDSHSEMGDHTECGH 1310
            ||.....|.....|.          |||:..    .|......|..:| |:.|.:.|.|..    
 Frog  1173 HARSRMLQRHHTIQT----------SDDAYV----QLDSLTGMSLVAG-KALSSARMADAV---- 1218

  Fly  1311 LTPDSMCDSRRMSDEMCYEVPLPHECSNLDSTRILEMVKQTIDSTMPPKGFVLHKGSISSEDSGA 1375
            |:..|:..|:::.|.              :|...:|..::|..|.:              .||| 
 Frog  1219 LSRSSLMGSQQLQDG--------------ESEDYVENPEETDLSLL--------------GDSG- 1254

  Fly  1376 ESRHSSASNASTSNPLACEAASLLASHSGYGEPTTNLSLEYSG 1418
              :|.         |.:|..:::|.   ||.....|.|:|.:|
 Frog  1255 --QHL---------PTSCFPSTMLL---GYKHTDLNFSMEQAG 1283

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sik3NP_001188969.1 PKc_like 40..292 CDD:304357 179/251 (71%)
S_TKc 41..292 CDD:214567 178/250 (71%)
UBA_SIK 335..380 CDD:270523 15/44 (34%)
sik3XP_004916140.2 STKc_SIK 25..277 CDD:270973 179/251 (71%)
UBA_SIK3 306..350 CDD:270593 16/47 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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