DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and mark4

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_012824414.1	Gene:	mark4 / 100491038	XenbaseID:	XB-GENE-6042140	Length:	681	Species:	Xenopus tropicalis

Alignment Length:	791	Identity:	261/791 - (32%)
Similarity:	372/791 - (47%)	Gaps:	165/791 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTK 66
            |:||.:.|...|           .:.|:.||.:...||.|.|.:||||||||.||||.:::|..:
Frog    23 ASTPLSWPPRPP-----------GARSRSSVPEEPHVGNYRLLRTIGKGNFAKVKLARHVLTGRE 76

  Fly    67 VAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVA 131
            |||||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:||:.|||..||:||:||:
Frog    77 VAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVS 141

  Fly   132 NGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKT 196
            :|||||.||...|.|:||||||||::.:|||||||||:|||.:.|||:|||||||.:..|..|.|
Frog   142 HGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDSESNIKIADFGFSNEFTPGGKLDT 206

  Fly   197 WCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFM 261
            :||||||||||:|||..|:||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:|
Frog   207 FCGSPPYAAPELFQGKRYNGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 271

  Fly   262 SQECEQLIRNMLVVEPDRRYTIKQIIKHRWLS-EWQSEMQEQERFGDMSPGSGTVSKSASTSSLG 325
            |.:||.::|..||:.|.:|.|:.||:..:|:: .:.|:        |:.|.......:|
Frog   272 STDCEGVLRRFLVLNPSKRCTLDQIMNDKWMNIGFDSD--------DLKPYKEPEEDNA------ 322

  Fly   326 SASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHA 390
                .|.:::  :|..|    |.:.:.|..::...:::.:.|.|.||..|.:....|:   :..:
Frog   323 ----DPKRIE--IMLEM----GYSREEIKDALSSNKYNEVMATYLLLGRKPESEGGES---RSDS 374

  Fly   391 SLAYSRSRKTSITTGVVDRSEPV----------KQESLDRLSPL-SNANASSSALGFGWSDVAVD 444
            :|:.||||..|..|....:|..|          ::...|...|. :.:.|..|..|.| .|.||
Frog   375 TLSLSRSRVASDVTNGATKSSSVHSKNQRGYQRQRRHSDFCGPAPAPSQAKRSPPGVG-DDGAV- 437

  Fly   445 LEKYGDFELECLARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPN------- 502
                                 .:.|:...|.|..|..:|........|:|..   |||
Frog   438 ---------------------GERLAPRRGSGSVGGGSRPPPPSSPMVSHAH---NPNKAEIPEP 478

  Fly   503 ---VPPIDFKCPP---------QCSDPTQPVPYYPVNLPMLQNQPLHNLTIKDQHLLKPPVVM-G 554
               .||.....||         .|:|.....          ::..|||.........:||.:. .
Frog   479 RKEAPPTTINTPPGVMGRRNTYVCTDRHSSE----------RHSLLHNDKENSSTPSRPPALSPS 533

  Fly   555 ASSFGRRAS-DGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTDPLAVQELSPLNEQSVA 618
            ..|...|:| ..|:|:.      .|..|   |...|..|....|:..|.|     ...||:.
Frog   534 TQSIAERSSLSRGSNVR------STFHG---GHVRDRRGQNPPPSSPTHP-----HEGLNQS--- 581

  Fly   619 QMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQRRTG 683
                 :..||.....:|.|.:.:|...:...|...|        ..||......||:|     :.
Frog   582 -----RTRATSNLFSKLTSKLTRRVTDESERVWRPE--------VTGSYIPWNKTSAN-----SS 628

  Fly   684 LLTVTERPPVIPPEIIREVESRMKRDYLPPTLKSLSQSPPNGTYPVGAALPMGMSKGLSPPHSLP 748
            ||    |||       |:|....:...|.||..|::   ||....:|...|:       |....|
Frog   629 LL----RPP-------RDVRRSSQHPPLQPTETSIA---PNSPSSIGRPSPL-------PGKLRP 672

  Fly   749 LVAAAGGSVPL 759
            |:..  |:|.|
Frog   673 LITV--GTVGL 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	148/251 (59%)
		S_TKc	41..292	CDD:214567	148/250 (59%)
		UBA_SIK	335..380	CDD:270523	9/44 (20%)
mark4	XP_012824414.1	STKc_MARK	50..302	CDD:270974	148/251 (59%)
mark4	XP_012824414.1	UBA_MARK_Par1	323..361	CDD:270522	9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910