DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and Gm10662

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001188293.1	Gene:	Gm10662 / 100043665	MGIID:	3642760	Length:	313	Species:	Mus musculus

Alignment Length:	249	Identity:	107/249 - (42%)
Similarity:	159/249 - (63%)	Gaps:	3/249 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 YELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYE 105
            |::..|:|:|||:|||.|.::.|.|.||:||:..|   :||.:...||..|:|||.||:|.:|:.
Mouse    34 YKMLNTLGEGNFSVVKRAFHVPTSTSVAVKILQNT---KEYTSPICREARIMKSLSHPNIIKLFH 95

  Fly   106 VMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVL 170
            |::.:...|||.|||..||:.|.::....::|.|..|:|.|:|.||.|||...:||||:||.|:|
Mouse    96 VVQRRETTYLVMEYASEGELLDRIINVVSLEESETRRLFAQIVHAVQYCHDHHIVHRDIKASNIL 160

  Fly   171 LDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGA 235
            :|...|.||.|||.:.....|..|..:||:.||.|||:.|..:|:|...|||||||:|:.:|.|.
Mouse   161 IDCRGNAKLCDFGLAAEVIPGQKLAGFCGTLPYCAPELLQAEKYEGLPVDIWSLGVLLFLMVSGN 225

  Fly   236 LPFDGKTILELKSRVVLGKFRIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKH 289
            |||.|::.::||..::...|.||..:|.:...:|..:|::.|.||.||.||::|
Mouse   226 LPFQGRSFVDLKQEIISANFSIPSHVSIDISNVIIELLMINPSRRPTIHQIMRH 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	107/249 (43%)
		S_TKc	41..292	CDD:214567	107/249 (43%)
		UBA_SIK	335..380	CDD:270523
Gm10662	NP_001188293.1	STKc_AMPK-like	33..280	CDD:270905	107/249 (43%)
Gm10662	NP_001188293.1	S_TKc	34..282	CDD:214567	107/249 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810