DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and mark2b

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	XP_009301419.1	Gene:	mark2b / 100005996	ZFINID:	ZDB-GENE-080215-4	Length:	790	Species:	Danio rerio

Alignment Length:	794	Identity:	256/794 - (32%)
Similarity:	366/794 - (46%)	Gaps:	160/794 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTK 66
            :::.|...|.....||.|:.....:|:    ::...:|.|.|.|||||||||.||||.:::|..:
Zfish    14 SSSQTHSDAKGGVRSSAPRCRNAVATA----EEYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKE 74

  Fly    67 VAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVA 131
            ||:||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|:...:|||.|||..||:||:|||
Zfish    75 VAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVA 139

  Fly   132 NGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKT 196
            :|||||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|
Zfish   140 HGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDT 204

  Fly   197 WCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFM 261
            :||||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:|
Zfish   205 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 269

  Fly   262 SQECEQLIRNMLVVEPDRRYTI-KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLG 325
            |.:||.|::..|::.|.:|.:: :||:|.||::....:       .|:.|
Zfish   270 STDCENLLKKFLILNPTKRGSLEQQIMKDRWMNVGYED-------DDLKP--------------- 312

  Fly   326 SASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHA 390
            .....|...|......|||: |.:.:.|..|:.:|:::.:.|.|.||..:       |..|....
Zfish   313 YIEPQPDYKDPRRTDIMLQM-GFSQEEIEDSLVKQKYNEVMATYLLLDYR-------NSELDEGV 369

  Fly   391 SLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELEC 455
            :|:.              :|.|.        |.|:|:||.|.                 ..:::.
Zfish   370 NLSL--------------KSRPG--------SDLTNSNAPSP-----------------PHKVQR 395

  Fly   456 LARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPP---IDFKCPPQCSDP 517
            ...|...|...............|.|  :|  |..|...:.:.::..|||   |..:.....:..
Zfish   396 SVSSTQKPARRSTDQGSYSKRPQGEN--KH--GVEDSGRKGSSSSTKVPPSPVISSERKKSSTPS 456

  Fly   518 TQPVPYYPVNLPMLQNQPL-HNLTIKDQH----LLKP----------PVVMGASSFGR------- 560
            |..:  ........:|.|: ...|:..|:    |..|          ||:..:||..|
Zfish   457 TNSI--LSTGTSRSRNSPISERATLGVQNGKDSLSTPGSRASTASAGPVLSSSSSSSRTRHHKSL 519

  Fly   561 --RASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTD----PLAV--QELSPLNEQSV 617
              .|....|:||.:.|:.    .|.:......:.:.|:...|||    |..|  :....|.:|..
Zfish   520 STSAHPSPADLHSHRPSD----PPQRAPGASPSAHNISSAAGTDRTNFPRGVPTRNTFHLGQQRG 580

  Fly   618 AQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQ--- 679
            |:.|                     .|:..|  |.....|::||:   ||.:.|..|....:
Zfish   581 ARDQ---------------------QGSPYH--GAPASPSLSHGN---SQQRRPAASGIFSKFTS 619

  Fly   680 ---RRTGLLTVTERPPVI-------PPEIIREVESRMKRDYLP-PTLKSLSQSPPNGTYPVGAAL 733
               ||........|.|..       ...::...|...|....| ...|..|.||..||.|   |.
Zfish   620 KFVRRNLSFRFPRRSPYEGEGQEEGSRSMLSSAEKSEKTSVGPEDENKDPSSSPGGGTPP---AA 681

  Fly   734 PMGMSKGLSPPHSL 747
            |:...|..|.|.||
Zfish   682 PVSSLKDQSKPRSL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	152/252 (60%)
		S_TKc	41..292	CDD:214567	152/251 (61%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
mark2b	XP_009301419.1	STKc_MARK	48..301	CDD:270974	152/252 (60%)
		S_TKc	49..301	CDD:214567	152/251 (61%)
		UBA_MARK2	319..360	CDD:270589	12/41 (29%)
		AMPKA_C_like	691..789	CDD:302605	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810