Protein Alignment Sik3 and mark2b

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_009301419.1
• Gene: mark2b / 100005996
• ZFINID: ZDB-GENE-080215-4
• Length: 790
• Species: Danio rerio
• Alignment Length: 794
• Identity: 256/794 - (32%)
• Similarity: 366/794 - (46%)
• Gaps: 160/794 - (20%)

  Fly     2 ATTPTAGPAAAPPTSSTPQNYKVPSTSKISVDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTK 66
            :::.|...|.....||.|:.....:|:    ::...:|.|.|.|||||||||.||||.:::|..:
Zfish    14 SSSQTHSDAKGGVRSSAPRCRNAVATA----EEYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKE 74

  Fly    67 VAIKIIDKTCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVA 131
            ||:||||||.||...|.|.|||:.|:|.|.||:|.:|:||:|:...:|||.|||..||:||:|||
Zfish    75 VAVKIIDKTQLNSSSLQKVFREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVA 139

  Fly   132 NGRMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKT 196
            :|||||.||...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|..|.|
Zfish   140 HGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDT 204

  Fly   197 WCGSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFM 261
            :||||||||||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:|
Zfish   205 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYM 269

  Fly   262 SQECEQLIRNMLVVEPDRRYTI-KQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLG 325
            |.:||.|::..|::.|.:|.:: :||:|.||::....:       .|:.|
Zfish   270 STDCENLLKKFLILNPTKRGSLEQQIMKDRWMNVGYED-------DDLKP--------------- 312

  Fly   326 SASDSPPQLDSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHA 390
            .....|...|......|||: |.:.:.|..|:.:|:::.:.|.|.||..:       |..|....
Zfish   313 YIEPQPDYKDPRRTDIMLQM-GFSQEEIEDSLVKQKYNEVMATYLLLDYR-------NSELDEGV 369

  Fly   391 SLAYSRSRKTSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELEC 455
            :|:.              :|.|.        |.|:|:||.|.                 ..:::.
Zfish   370 NLSL--------------KSRPG--------SDLTNSNAPSP-----------------PHKVQR 395

  Fly   456 LARSNDPPVNAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPP---IDFKCPPQCSDP 517
            ...|...|...............|.|  :|  |..|...:.:.::..|||   |..:.....:..
Zfish   396 SVSSTQKPARRSTDQGSYSKRPQGEN--KH--GVEDSGRKGSSSSTKVPPSPVISSERKKSSTPS 456

  Fly   518 TQPVPYYPVNLPMLQNQPL-HNLTIKDQH----LLKP----------PVVMGASSFGR------- 560
            |..:  ........:|.|: ...|:..|:    |..|          ||:..:||..|
Zfish   457 TNSI--LSTGTSRSRNSPISERATLGVQNGKDSLSTPGSRASTASAGPVLSSSSSSSRTRHHKSL 519

  Fly   561 --RASDGGANLHIYYPATGTVVGPAQGQQMDTAGYYINPNCGTD----PLAV--QELSPLNEQSV 617
              .|....|:||.:.|:.    .|.:......:.:.|:...|||    |..|  :....|.:|..
Zfish   520 STSAHPSPADLHSHRPSD----PPQRAPGASPSAHNISSAAGTDRTNFPRGVPTRNTFHLGQQRG 580

  Fly   618 AQMQCCQENATGECNEELQSYMQKRGGTQRHTVGCTEDLSVAHGSGAGSQSQAPTTSSNMRQ--- 679
            |:.|                     .|:..|  |.....|::||:   ||.:.|..|....:
Zfish   581 ARDQ---------------------QGSPYH--GAPASPSLSHGN---SQQRRPAASGIFSKFTS 619

  Fly   680 ---RRTGLLTVTERPPVI-------PPEIIREVESRMKRDYLP-PTLKSLSQSPPNGTYPVGAAL 733
               ||........|.|..       ...::...|...|....| ...|..|.||..||.|   |.
Zfish   620 KFVRRNLSFRFPRRSPYEGEGQEEGSRSMLSSAEKSEKTSVGPEDENKDPSSSPGGGTPP---AA 681

  Fly   734 PMGMSKGLSPPHSL 747
            |:...|..|.|.||
Zfish   682 PVSSLKDQSKPRSL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	152/252 (60%)
		UBA_SIK	335..380	CDD:270523	12/44 (27%)
mark2b	XP_009301419.1	STKc_MARK	48..301	CDD:270974	152/252 (60%)
		UBA_MARK2	319..360	CDD:270589	12/41 (29%)
		AMPKA_C_like	691..789	CDD:473060	3/5 (60%)