Protein Alignment Sik3 and mark1

DIOPT Version :10

• Sequence 1: NP_611361.4
• Gene: Sik3 / 37152
• FlyBaseID: FBgn0262103
• Length: 1471
• Species: Drosophila melanogaster
• Sequence 2: XP_073792238.1
• Gene: mark1 / 100003170
• ZFINID: ZDB-GENE-070626-2
• Length: 795
• Species: Danio rerio
• Alignment Length: 852
• Identity: 269/852 - (31%)
• Similarity: 389/852 - (45%)
• Gaps: 205/852 - (24%)

  Fly    11 AAPPTSSTPQNYKVPSTSKISV-DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDK 74
            |||..||:.|:......|..|: |:...||.|.|.|||||||||.||||.:::|..:||:|||||
Zfish    29 AAPTKSSSRQSLPRSRNSVASITDEQPHVGNYRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDK 93

  Fly    75 TCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPE 139
            |.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:||:.|||..||:||:|||:|||||.|
Zfish    94 TQLNPTSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKE 158

  Fly   140 AARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYA 204
            |...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|:.|.|:|||||||
Zfish   159 ARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYA 223

  Fly   205 APEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLI 269
            |||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||.:||.|:
Zfish   224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 288

  Fly   270 RNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQL 334
            :.:||:.|.:|.:::||:|..|::....|                       ..|...::..|..
Zfish   289 KKLLVLNPGKRGSLEQIMKDHWINVGHEE-----------------------EELKPYTEPEPDF 330

  Fly   335 DSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRK 399
            .......::...|...|.|.:::..|::|.:.|.|.||       .|:....:...||:
Zfish   331 SDTKRIELMITMGFPKDEITEALVGQKYDEVMATYLLL-------GRKPPEFEGSDSLS------ 382

  Fly   400 TSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPV 464
               ||.:..||.|        .|.|:|:::.|.|    .|.|               .||.....
Zfish   383 ---TTNLCQRSRP--------SSDLNNSSSQSPA----HSKV---------------QRSISATQ 417

  Fly   465 NAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLP 529
            ..:..|.|..                          |::||              .|.|
Zfish   418 KQRRFSDHVA--------------------------PSIPP--------------AVSY------ 436

  Fly   530 MLQNQPLHNLTIKDQHLLKPPVVMGASSF-GRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGY 593
                      |.:.|          |:|. |.:..:..|:..:          |:...:.|.|
Zfish   437 ----------TKRSQ----------ANSVEGEKKEEWDASRKL----------PSSSSKGDMA-- 469

  Fly   594 YINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTV---GCTED 655
                   ..|||.||   ..:.|.|.    ..:|.|..... .:|:.:|..|.|::.   |....
Zfish   470 -------ASPLAAQE---RRKSSTAS----GNSAAGGMTRR-NTYVCERSSTDRYSAIPNGKDSS 519

  Fly   656 LSVAHGSGAGSQSQAPTTS--SNMRQRRTGLLTVTERPPVIP-PEIIREVESRMKRDYLP---PT 714
            |:....||:|:.|.:|..|  |:.|.|....::.:..|...| |.|....|.:......|   |:
Zfish   520 LTEMSTSGSGTSSVSPGASALSSTRPRHVKSMSASGHPNKSPLPPIEDNTEFKGSGSRAPSTSPS 584

  Fly   715 LKSLSQSPPNGT-YP---------VGAALPMGMSKGLSPPHSLPLVAAAGGSV------------ 757
            ..|:|...|:.| :|         .||.|....|...:.|.:.|.::...|::
Zfish   585 AHSISSMTPDRTRFPRGTSSRSTFHGAQLRDRRSATYNGPPASPTLSHDTGALAQARRGTSSGFI 649

  Fly   758 -PLVAPNNRRIHRVVHSKLPTVQEGATIGRYSPVRRAS-----EGSKS-----QFQGPLQECQSL 811
             .|.:...||......::||:  ||...||...:|..|     :|..|     :|...::...||
Zfish   650 SKLTSKFVRRTLSFRSARLPS--EGEARGRAYSLRSGSGEPKEDGRDSKPRSLRFTWSMKTTSSL 712

  Fly   812 QKGIAQR 818
            :.|...|
Zfish   713 EPGDMMR 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_611361.4	Protein Kinases, catalytic domain	40..292	CDD:473864	151/251 (60%)
		UBA_SIK	335..380	CDD:270523	9/44 (20%)
mark1	XP_073792238.1	None