DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sik3 and mark1

DIOPT Version :9

Sequence 1:	NP_001188969.1	Gene:	Sik3 / 37152	FlyBaseID:	FBgn0262103	Length:	1471	Species:	Drosophila melanogaster
Sequence 2:	NP_001107948.1	Gene:	mark1 / 100003170	ZFINID:	ZDB-GENE-070626-2	Length:	772	Species:	Danio rerio

Alignment Length:	845	Identity:	264/845 - (31%)
Similarity:	380/845 - (44%)	Gaps:	214/845 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AAPPTSSTPQNYKVPSTSKISV-DKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDK 74
            |||..||:.|:......|..|: |:...||.|.|.|||||||||.||||.:::|..:||:|||||
Zfish    29 AAPTKSSSRQSLPRSRNSVASITDEQPHVGNYRLLKTIGKGNFAKVKLARHVLTGREVAVKIIDK 93

  Fly    75 TCLNEEYLNKTFREIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPE 139
            |.||...|.|.|||:.|:|.|.||:|.:|:||:|::..:||:.|||..||:||:|||:|||||.|
Zfish    94 TQLNPTSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKE 158

  Fly   140 AARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFGFSNHYEEGATLKTWCGSPPYA 204
            |...|.|:||||.|||::.:|||||||||:|||.|||||:|||||||.:..|:.|.|:|||||||
Zfish   159 ARAKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTLGSKLDTFCGSPPYA 223

  Fly   205 APEVFQGLEYDGPKSDIWSLGVVLYALVCGALPFDGKTILELKSRVVLGKFRIPFFMSQECEQLI 269
            |||:|||.:||||:.|:|||||:||.||.|:|||||:.:.||:.||:.||:||||:||.:||.|:
Zfish   224 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLL 288

  Fly   270 RNMLVVEPDRRYTIKQIIKHRWLSEWQSEMQEQERFGDMSPGSGTVSKSASTSSLGSASDSPPQL 334
            :.:||:.|.:|.:::||:|..|::....|                       ..|...::..|..
Zfish   289 KKLLVLNPGKRGSLEQIMKDHWINVGHEE-----------------------EELKPYTEPEPDF 330

  Fly   335 DSVVMTHMLQLPGLTADMIAQSVHEQRFDNIYAIYNLLHDKLQQRRRENQRLQHHASLAYSRSRK 399
            .......::...|...|.|.:::..|::|.:.|.|.||       .|:....:...||:
Zfish   331 SDTKRIELMITMGFPKDEITEALVGQKYDEVMATYLLL-------GRKPPEFEGSDSLS------ 382

  Fly   400 TSITTGVVDRSEPVKQESLDRLSPLSNANASSSALGFGWSDVAVDLEKYGDFELECLARSNDPPV 464
               ||.:..||.|        .|.|:|:::.|.|    .|.|               .||.....
Zfish   383 ---TTNLCQRSRP--------SSDLNNSSSQSPA----HSKV---------------QRSISATQ 417

  Fly   465 NAQHLSAHAGGGVNGANTRRHTVGPGDVAHEQALANPNVPPIDFKCPPQCSDPTQPVPYYPVNLP 529
            ..:..|.|..                          |::||              .|.|
Zfish   418 KQRRFSDHVA--------------------------PSIPP--------------AVSY------ 436

  Fly   530 MLQNQPLHNLTIKDQHLLKPPVVMGASSF-GRRASDGGANLHIYYPATGTVVGPAQGQQMDTAGY 593
                      |.:.|          |:|. |.:..:..|:..:          |:...:.|.|
Zfish   437 ----------TKRSQ----------ANSVEGEKKEEWDASRKL----------PSSSSKGDMA-- 469

  Fly   594 YINPNCGTDPLAVQELSPLNEQSVAQMQCCQENATGECNEELQSYMQKRGGTQRHTV---GCTED 655
                   ..|||.||   ..:.|.|.    ..:|.|..... .:|:.:|..|.|::.   |....
Zfish   470 -------ASPLAAQE---RRKSSTAS----GNSAAGGMTRR-NTYVCERSSTDRYSAIPNGKDSS 519

  Fly   656 LSVAHGSGAGSQSQAPTTS--SNMRQRRTGLLTVTERPPVIP-PEIIREVESRMKRDYLP---PT 714
            |:....||:|:.|.:|..|  |:.|.|....::.:..|...| |.|....|.:......|   |:
Zfish   520 LTEMSTSGSGTSSVSPGASALSSTRPRHVKSMSASGHPNKSPLPPIEDNTEFKGSGSRAPSTSPS 584

  Fly   715 LKSLSQSPPNGT-YP---------VGAALPMGMSKGLSPPHSLPLVAAAGGSVPLVAPNNRRIHR 769
            ..|:|...|:.| :|         .||.|....|...:.|.:.|.::...|:
Zfish   585 AHSISSMTPDRTRFPRGTSSRSTFHGAQLRDRRSATYNGPPASPTLSHDTGA------------- 636

  Fly   770 VVHSKLPTVQEGATIGRYSP-----VRRASEGSKSQ-----------FQGPLQECQSLQKGIAQR 818
                 |...:.|.:.|..|.     |||:..|...:           |...::...||:.|...|
Zfish   637 -----LAQARRGTSSGFISKLTSKFVRRSGSGEPKEDGRDSKPRSLRFTWSMKTTSSLEPGDMMR 696

Fly 819 818
Zfish 697 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sik3	NP_001188969.1	PKc_like	40..292	CDD:304357	151/251 (60%)
		S_TKc	41..292	CDD:214567	151/250 (60%)
		UBA_SIK	335..380	CDD:270523	9/44 (20%)
mark1	NP_001107948.1	STKc_MARK	59..311	CDD:270974	151/251 (60%)
		S_TKc	60..311	CDD:214567	151/250 (60%)
		UBA_MARK1	331..371	CDD:270588	9/46 (20%)
		MARK1-3_C	673..770	CDD:213381	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910