DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gint3 and UBXN6

DIOPT Version :9

Sequence 1:	NP_611356.1	Gene:	Gint3 / 37148	FlyBaseID:	FBgn0034372	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	XP_016882814.1	Gene:	UBXN6 / 80700	HGNCID:	14928	Length:	475	Species:	Homo sapiens

Alignment Length:	446	Identity:	150/446 - (33%)
Similarity:	239/446 - (53%)	Gaps:	23/446 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KAEAAFKLNLTGSGMGTGHKLNSPKQETPSSSSRQKYEAYVPPKRNEISNEARAAASAALARIDK 76
            ||.:|.:..|....:....|...|.....:...:....|..||::.. :|||:.||:|||||:::
Human    36 KAPSAREARLVDCHVAGQGKAGLPAAREKAHKEKPNQPAPRPPRQGP-TNEAQMAAAAALARLEQ 99

  Fly    77 KTSREFN-TSLSAVKAQAKRELEAERRQREEAMGTPSTTSTSTSASGGD--TRNLACEGVFFRCP 138
            |.||.:. ||...::.|.::||:||    ....|:|....|:..:...:  :.:||..||:|.||
Human   100 KQSRAWGPTSQDTIRNQVRKELQAE----ATVSGSPEAPGTNVVSEPREEGSAHLAVPGVYFTCP 160

  Fly   139 LISEEILPKSVWKVRIKEFLYQQLEADRGLTACLIIHNCNV-KEKADECIATLIRYLENLIKNPE 202
            | :...|.|......|||.:......|....:.:.|:..|. :::....:.|:.:||:|:..:||
Human   161 L-TGATLRKDQRDACIKEAILLHFSTDPVAASIMKIYTFNKDQDRVKLGVDTIAKYLDNIHLHPE 224

  Fly   203 EEKFCKIRMSNKIFSEKVRYVEGALDVLQAAGFNEV------QIDGEPFLLWTKEQTEKDLDLPT 261
            |||:.||::.||:|.|::..:||..:..:|.||.:|      |.|.|.|.:.::....:...|..
Human   225 EEKYRKIKLQNKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFYVLSETTLAQPQSLER 289

  Fly   262 LVEALKSSEIIPLELDRNIKVLLPSQ-ACRVALPDEFYRLSPEEIKKEQQLRSEAIAQSQMLRTK 325
            ..|.|.::|.:..:|||..:|..||. |.:..||.:|:.|:.||||:||:|||||:.:..:||||
Human   290 HKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEIKREQRLRSEAVERLSVLRTK 354

  Fly   326 AMREREEQRNLRMYRYALVRVKFPNGLFIQGTFNVYEKISDVFEFVQSCLADESLDFSLVSNSDG 390
            ||||:||||.||.|.|.|:||:.|:|..:||||...|::..|:.||:..|..:.|.|.|:::...
Human   355 AMREKEEQRGLRKYNYTLLRVRLPDGCLLQGTFYARERLGAVYGFVREALQSDWLPFELLASGGQ 419

  Fly   391 KLGDEDLEKTLYDCKLIPNTLLLFS-----ANDTPAPLQTDINYLKEDLLMLVQAM 441
            || .||....|.:|.|:|:.||.||     ..|..|......:.||.:||..::.:
Human   420 KL-SEDENLALNECGLVPSALLTFSWDMAVLEDIKAAGAEPDSILKPELLSAIEKL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gint3	NP_611356.1	PUB_UBXD1	171..268	CDD:198418	30/103 (29%)
Gint3	NP_611356.1	UBQ	341..414	CDD:294102	28/72 (39%)
UBXN6	XP_016882814.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145651
Domainoid	1	1.000	73	1.000	Domainoid score	I9282
eggNOG	1	0.900	-	-		E1_KOG2699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11538
Inparanoid	1	1.050	230	1.000	Inparanoid score	I3446
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006526
OrthoInspector	1	1.000	-	-		oto91428
orthoMCL	1	0.900	-	-		OOG6_106206
Panther	1	1.100	-	-	LDO	PTHR23153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4113
SonicParanoid	1	1.000	-	-		X5502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790