DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gint3 and Ubxn6

DIOPT Version :9

Sequence 1:	NP_611356.1	Gene:	Gint3 / 37148	FlyBaseID:	FBgn0034372	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001366290.1	Gene:	Ubxn6 / 66530	MGIID:	1913780	Length:	442	Species:	Mus musculus

Alignment Length:	473	Identity:	156/473 - (32%)
Similarity:	252/473 - (53%)	Gaps:	67/473 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKKFFSRKKAEAAFKLNLTGSGMGTGHKL------NSPKQETPSSSSRQKYEAYVPPKRNEISNE 62
            :||||...||:..||      ..|.|.||      .:.|.::|..:.||       |::.. ::|
Mouse     1 MKKFFQEIKADIKFK------SAGPGQKLTDSAGEKTTKGKSPQLALRQ-------PRQGP-TDE 51

  Fly    63 ARAAASAALARIDKKTSREFN-TSLSAVKAQAKRELEAERRQREEAMGTPSTTSTSTSASGGD-- 124
            |:.||:|||||:::|..|... ||..:::.|.::||:||           :|:|.:..|.|.:
Mouse    52 AQMAAAAALARLEQKQPRARGPTSQDSIRNQVRKELQAE-----------ATSSNNPGAPGTNSV 105

  Fly   125 -------TRNLACEGVFFRCPLISEEILPKSVWKVRIKEFLYQQLEADRGLTACLIIHNCN-VKE 181
                   :.:||..||||.||| :...|.:......||:.:......|....:.:.||..| .::
Mouse   106 PEPKEEISPHLAVPGVFFICPL-TGVTLRRDQRDAHIKQAILSHFSTDPVAASIMKIHTFNRDRD 169

  Fly   182 KADECIATLIRYLENLIKNPEEEKFCKIRMSNKIFSEKVRYVEGALDVLQAAGFNEVQI-----D 241
            :....:.|:.:||:|:..:|||||:.||::.||:|.|::..:||:.:..:|.||.:|.:     :
Mouse   170 RVKLGVDTIAKYLDNIHLHPEEEKYQKIKLQNKVFQERINCLEGSHEFFEAIGFKKVTLPVPDQE 234

  Fly   242 G-EPFLLWTKEQTEKDLDLPTLVEALKSSEIIPLELDRNIKVLLPSQ-ACRVALPDEFYRLSPEE 304
            | |.|.:..::...:..:|....:.|..:|.:...|||.::|..||. |....||.:|:.|:.||
Mouse   235 GQEEFYVLGEDARAQPQNLARHKQQLLDAEPVRATLDRQLRVFRPSALASHFELPSDFFSLTAEE 299

  Fly   305 IKKEQQLRSEAIAQSQMLRTKAMREREEQRNLRMYRYALVRVKFPNGLFIQGTFNVYEKISDVFE 369
            :|:||:||:||:.:...||||||||:||||.||.|.||||||:.|:|..:||||...||:|.:|.
Mouse   300 VKREQRLRTEAVERLSSLRTKAMREKEEQRELRKYTYALVRVRLPDGCLLQGTFYAREKLSALFR 364

  Fly   370 FVQSCLADESLDFSLVSNSDGKLGDEDLEKTLYDCKLIPNTLLLFS-----------ANDTPAPL 423
            ||:..|.::.|.|.|.::...|| :|:....|.:|.|:|:.||.||           |...||.
Mouse   365 FVREALQNDWLPFELRASGGQKL-EENEALALNECGLVPSALLTFSWDASVLEDIRAAGAEPAK- 427

  Fly   424 QTDINYLKEDLLMLVQAM 441
                :.|:.:||..::.:
Mouse   428 ----SVLRPELLAAIEQL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gint3	NP_611356.1	PUB_UBXD1	171..268	CDD:198418	29/103 (28%)
Gint3	NP_611356.1	UBQ	341..414	CDD:294102	31/72 (43%)
Ubxn6	NP_001366290.1	Mediates interaction with LMAN1. /evidence=ECO:0000250\|UniProtKB:Q9BZV1	1..10		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..111		33/122 (27%)
		VCP/p97-interacting motif (VIM). /evidence=ECO:0000250\|UniProtKB:Q9BZV1	51..63		8/11 (73%)
		PUB_UBXD1	158..261	CDD:198418	28/102 (27%)
		UBX_UBXN6	336..409	CDD:340536	31/73 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835717
Domainoid	1	1.000	70	1.000	Domainoid score	I9543
eggNOG	1	0.900	-	-		E1_KOG2699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11538
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3539
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006526
OrthoInspector	1	1.000	-	-		oto95010
orthoMCL	1	0.900	-	-		OOG6_106206
Panther	1	1.100	-	-	LDO	PTHR23153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4113
SonicParanoid	1	1.000	-	-		X5502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790