DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gint3 and ubxn6

DIOPT Version :9

Sequence 1:	NP_611356.1	Gene:	Gint3 / 37148	FlyBaseID:	FBgn0034372	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001038245.1	Gene:	ubxn6 / 554960	ZFINID:	ZDB-GENE-030131-5680	Length:	437	Species:	Danio rerio

Alignment Length:	469	Identity:	174/469 - (37%)
Similarity:	252/469 - (53%)	Gaps:	64/469 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IKKFFSRKKAEAAFKLNLTGSGMGTGHKLNSPKQETPSSSSRQKYEAYVPPKRNEISNEARAAAS 68
            :||||...|.:..||      ..|.|.||..     .|||..|..:|.....|...:..|:.|.:
Zfish     1 MKKFFDDIKKDIKFK------SAGPGKKLTD-----ESSSKPQASQASHAASRKAPTAGAQMAGA 54

  Fly    69 AALARIDKKTSREFNTSLSAVKAQAKRELEAE--------RRQREEAMGTPSTTSTSTSASGGDT 125
            ||||||:::...:.:||..|::.|.|||||||        :....|....|...|:|.|.|
Zfish    55 AALARIEQQHRPKVHTSQDAIRNQVKRELEAEAAAVVASLKNTEIEGSAVPQRDSSSFSVS---- 115

  Fly   126 RNLACEGVFFRCPLISEEILPKSVWKVRIKEFLYQQLEADRGLTACLIIHNCNV-KEKADECIAT 189
                  ||||.|||..:.: .|:..::.|||.:..:...|....:.::||..|. |||....|..
Zfish   116 ------GVFFTCPLTGKTV-TKAERELHIKEAILMRFSEDAIEASIMMIHTFNKDKEKVKAAIDI 173

  Fly   190 LIRYLENLIKNPEEEKFCKIRMSNKIFSEKVRYVEGALDVLQAAGF--NEVQIDGEPFLLWTKEQ 252
            :.:|:||:.|||.|||:.||::.||:|.|||..:|||.:.|||.||  :.:.||||       |:
Zfish   174 ISKYIENICKNPTEEKYRKIKVGNKVFQEKVSGIEGAREYLQALGFESSTLPIDGE-------EK 231

  Fly   253 TEKDLDLPTL-----------VEALKSSEIIPLELDRNIKVLLPSQ-ACRVALPDEFYRLSPEEI 305
            ||..|.||..           :|.|:..|.:..:|||.::|..||| |....||.:||.||.||:
Zfish   232 TEDFLVLPEQDSDALEQMKIHLERLQKGEAVRAKLDRQLQVFRPSQNATHFELPPDFYNLSAEEL 296

  Fly   306 KKEQQLRSEAIAQSQMLRTKAMREREEQRNLRMYRYALVRVKFPNGLFIQGTFNVYEKISDVFEF 370
            ||||||:||.:.::.|||||||||::|||..|.|.|||:||:.|:|..:||||..:|::|.:::|
Zfish   297 KKEQQLKSEMVERNAMLRTKAMREKDEQRERRKYNYALLRVRLPDGNILQGTFLAWERLSALYQF 361

  Fly   371 VQSCLADESLDFSLVSNSDGKLGDEDLEKTLYDCKLIPNTLLLFSANDTPAPLQTDIN------- 428
            |:..|.::...|.|::....||.|:: |..:.:|.|.|..||.||.:   |.:|.||.
Zfish   362 VRDSLENDWQPFELMAPGGQKLKDDE-ETPINECNLAPAALLTFSWD---AAVQADIAAAGGKTA 422

  Fly   429 -YLKEDLLMLVQAM 441
             .||:.||..::::
Zfish   423 VLLKQALLENIKSL 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gint3	NP_611356.1	PUB_UBXD1	171..268	CDD:198418	44/110 (40%)
Gint3	NP_611356.1	UBQ	341..414	CDD:294102	27/72 (38%)
ubxn6	NP_001038245.1	PUB_UBXD1	154..256	CDD:198418	43/108 (40%)
ubxn6	NP_001038245.1	UBQ	330..403	CDD:294102	27/73 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579050
Domainoid	1	1.000	78	1.000	Domainoid score	I8730
eggNOG	1	0.900	-	-		E1_KOG2699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11538
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3240
OMA	1	1.010	-	-		QHG52756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006526
OrthoInspector	1	1.000	-	-		oto41682
orthoMCL	1	0.900	-	-		OOG6_106206
Panther	1	1.100	-	-	LDO	PTHR23153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4113
SonicParanoid	1	1.000	-	-		X5502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790