DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gint3 and ubxn-6

DIOPT Version :9

Sequence 1:	NP_611356.1	Gene:	Gint3 / 37148	FlyBaseID:	FBgn0034372	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_500648.2	Gene:	ubxn-6 / 177253	WormBaseID:	WBGene00019163	Length:	437	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	135/440 - (30%)
Similarity:	215/440 - (48%)	Gaps:	49/440 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKIKKFFSRKKAEAAFKLNLTGSGMGTGHKLNSPKQETPSSSSRQKYEAYVPPKRNEISNEARA 65
            |:..|||.::|:.:..||.:..|..:.:|...:.|.....::...|            |...|.|
Worm     1 MNSFKKFLNKKRVQNHFKKSGEGVRLSSGESSSQPSAHAGAAQGGQ------------IDRVAAA 53

  Fly    66 --AASAALARIDKKTSREFNTSLSAVKAQAKRELEAERRQREEAMGTPSTTSTSTSASGGDTRNL 128
              ||.||..|:.|...:: |.....::..||||||.||||.|:.    :.:.||:.......::|
Worm    54 DIAAQAAFKRMQKNEPQQ-NAGKRRIQMIAKRELEEERRQVEDL----NISGTSSLQQPDREQHL 113

  Fly   129 ----ACEGVFFRCPLISE-EILPKSVWKVRIKEFLYQQL-----EADRGLTACLIIHNCNVKEKA 183
                |...|.:...|:.| .|..|:.....||.||..|:     |.|:.:.|.|::::.|.|...
Worm   114 EHSSAISRVLYTSELLGEHHIRSKADLLEDIKNFLSDQISEADDENDKVIAAVLMLYSLNKKHPK 178

  Fly   184 DECIATLIRYLENLIKNPEEEKFCKIRMSNKIFSEKVRYVEGALDVLQAAGFNEVQIDGEPFLLW 248
            :..|.|:.:|.:|::::|.|:|:..||:.||.|.|:|..|.|....|:|.||.|.....:.||::
Worm   179 ETAIETICKYCQNILEHPGEDKYKSIRLGNKAFQERVASVVGGRAFLEAVGFTEKSEGEDKFLVF 243

  Fly   249 TKEQTEKDLDLPTLVEALKSSEIIPLELDRNIKVLLPSQACRVALP---DEFYRLSPEEIKKEQQ 310
            ||   ..|:.|...:||||..:.:|:::.||:::....:..:...|   |:||.||..|:|.||:
Worm   244 TK---PSDVHLVEALEALKDGQAVPIKVARNLEIFKLKEGQKPKAPKLADDFYNLSTAELKAEQR 305

  Fly   311 LRSEAIAQSQMLRTKAMREREEQRNLRMYRYALVRVKFPNGLFIQGTFNVYEKISDVFEFVQSCL 375
            .:...:.:...||||.||:::||.....|:|.|:||:.|..|.:||.|..:|..|.|..||.|.|
Worm   306 NKEMQVERMLTLRTKEMRQKDEQMTNYRYKYTLIRVRLPGNLLMQGVFGCHEPFSAVRVFVASTL 370

  Fly   376 ADESLDFSLVSNSDGKLGD------EDLEKTLYDCKLIPNTLL--LFSAN 417
            :|      .:|.|:..|.|      ||...:|....|.|..||  :|:.|
Worm   371 SD------ALSTSEFTLRDAASQLVEDESASLAQLSLAPAALLHVVFAEN 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gint3	NP_611356.1	PUB_UBXD1	171..268	CDD:198418	33/96 (34%)
Gint3	NP_611356.1	UBQ	341..414	CDD:294102	28/80 (35%)
ubxn-6	NP_500648.2	PUB_UBXD1	166..262	CDD:198418	34/98 (35%)
ubxn-6	NP_500648.2	UBQ	334..410	CDD:320785	29/81 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158677
Domainoid	1	1.000	54	1.000	Domainoid score	I7533
eggNOG	1	0.900	-	-		E1_KOG2699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11538
Inparanoid	1	1.050	176	1.000	Inparanoid score	I2697
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006526
OrthoInspector	1	1.000	-	-		oto18921
orthoMCL	1	0.900	-	-		OOG6_106206
Panther	1	1.100	-	-	LDO	PTHR23153
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4113
SonicParanoid	1	1.000	-	-		X5502
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830