DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and RSPRY1

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_011521729.1	Gene:	RSPRY1 / 89970	HGNCID:	29420	Length:	607	Species:	Homo sapiens

Alignment Length:	462	Identity:	84/462 - (18%)
Similarity:	147/462 - (31%)	Gaps:	131/462 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PVTPSRRQRRTRSMSRSPSPVQAAPVAAEPVLDTLEEEE--QPEDKTVPQPEPESEQPAAEPEPE 113
            ||.|.||.|......|....|....:....|:.||.::.  |.||..:.....:|........|.
Human    80 PVRPPRRGRGPHEPRRKKQNVDGLVLDTLAVIRTLVDKRKLQNEDAYIGPCFHKSSTGIVVSLPG 144

  Fly   114 QSEPEEAEPAAAVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPM 178
            .|..::..|.:.:|                   ..|.:|||:....:.:::..|:|    .::|:
Human   145 ISLSDQEPPYSMIT-------------------LHEMAETDEGWLDVVQSLIRVIP----LEDPL 186

  Fly   179 EEDHDAAPEEQEPTQTEEPVEEKPAESTVAEHQS-NGDSQKMDVDEEDSAAPKTAEETE------ 236
                  .|........|.|:..|.|...:.|..: ||     :|..:||:.|.....|.
Human   187 ------GPAVITLLLDECPLPTKDALQKLTEILNLNG-----EVACQDSSHPAKHRNTSAVLGCL 240

  Fly   237 ------PAA----------------KPEDQPPERRKRSHSRSKSRSRSGSRSSKHRGSVGD---- 275
                  ||:                |.:..|........:..|....|.::.:....|:.|
Human   241 AEKLAGPASIGLLSPGILEYLLQCLKLQSHPTVMLFALIALEKFAQTSENKLTISESSISDRLVT 305

  Fly   276 -----------KRESKAAA----------EERTVPEDEPTIEENKVGLSWLDSDLHLRIDPTTFA 319
                       ||:....|          |.|.:..::..:...:..|:..|...:|:|.|....
Human   306 LESWANDPDYLKRQVGFCAQWSLDNLFLKEGRQLTYEKVNLSSIRAMLNSNDVSEYLKISPHGLE 370

  Fly   320 SAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRVGFSMPKSS 384
            :....:|      :...|..:.|..|...:||.:....|               .::|::...|.
Human   371 ARCDASS------FESVRCTFCVDAGVWYYEVTVVTSGV---------------MQIGWATRDSK 414

  Fly   385 LL------LGEAEHSFGY--CETGRKATQSEFTDYGKP-----YQLDDVIGCYLDLESEPCTINY 436
            .|      :|:.|:|..|  |   |:...  :....||     ::..|.:|..|||..:  .:.:
Human   415 FLNHEGYGIGDDEYSCAYDGC---RQLIW--YNARSKPHIHPCWKEGDTVGFLLDLNEK--QMIF 472

  Fly   437 TLNGEDL 443
            .|||..|
Human   473 FLNGNQL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251
		SPRY_hnRNP	300..480	CDD:293942	32/157 (20%)
		PHA02664	<529..659	CDD:177447
		AAA_33	709..855	CDD:290396
		NK	709..>836	CDD:302627
		DUF1777	1033..>1104	CDD:285811
RSPRY1	XP_011521729.1	SPRY_RING	390..510	CDD:293941	24/112 (21%)
		RING-HC_RSPRY1	556..596	CDD:319480
		RING-HC finger (C3HC4-type)	558..592	CDD:319480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810