DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and Hnrnpul2

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001074665.1	Gene:	Hnrnpul2 / 68693	MGIID:	1915943	Length:	745	Species:	Mus musculus

Alignment Length:	1050	Identity:	275/1050 - (26%)
Similarity:	399/1050 - (38%)	Gaps:	388/1050 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVE----------GGAGDGENAPVTPSRRQR 59
            :::::||.:||:|||.||||::|:|..|.:||:..::          ||||.|......|
Mouse     2 EVKRLKVTELRSELQRRGLDSRGLKMDLAQRLQEALDAEMLEDEAGVGGAGPGGACKAEP----- 61

  Fly    60 RTRSMSRSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAA 124
                          .||||.......:|||:.:|      |.|.|:...|.|.|:..|.
Mouse    62 --------------RPVAASGGGPGGDEEEEDDD------EEEDEEALLEDEDEEPPPA------ 100

  Fly   125 AVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPME---------- 179
                     ||:.:.:||.|    |..||.           |:..::|.:|.|.|
Mouse   101 ---------QALGQAAQPPP----EPPETS-----------AMEAESEASDTPAEATAGSGGVNG 141

  Fly   180 -EDHD------AAPEEQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEP 237
             |:||      ..|||:...:|  |..|.|.:..|.|...:.||:|
Mouse   142 GEEHDNGKGEEDGPEERSGDET--PGSEAPGDKAVEEQGDDQDSEK------------------- 185

  Fly   238 AAKPEDQPPERR--------KRSHSRSKSRSRSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPT 294
             :||.....|||        |..|.|:....|..:..|:.:.....:.|:|...|::|:
Mouse   186 -SKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPPPPEEEAKDEEEDQTL------ 243

  Fly   295 IEENKVGLSWLDSDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSE---- 355
                 |.|....||||.:|....: ..:||.||.:..:|||||:.|||.:||||||.::::
Mouse   244 -----VNLDTYTSDLHFQISKDRY-GGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPM 302

  Fly   356 -ESVPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDD 419
             |...|          |...|||:|:..|...|||.|.|:|:...|.||...:|.::|:.:..:|
Mouse   303 KEGCTE----------VSLLRVGWSVDFSCSQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGEND 357

  Fly   420 VIGCYLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVN 484
            ||||:.:.|:|...::::.|||||||||...|..|.:. ||.||::.|.....:||...|
Mouse   358 VIGCFANFETEEVELSFSKNGEDLGVAFRISKESLADR-ALLPHVLCKNCVVELNFGQKE----- 416

  Fly   485 AERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDP 549

Mouse   417 ----------------------------------------------------------------- 416

  Fly   550 EKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQAND 614

Mouse   417 ----------------------------------------------------------------- 416

  Fly   615 EKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAAL 679
                                                                |...|.|
Mouse   417 ----------------------------------------------------EPFFPPP------ 423

  Fly   680 LEGYVLIGLVPVEKLVSGPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAF 744
             |.:|.|..||||:.|.......:.:||||||:|||||:|||.||.|:..:|.::||.::|.:..
Mouse   424 -EEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKDNPERRYNVLGAETV 487

  Fly   745 ISKMTIDGASRKTVHKGRWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFND 809
            :::|.:.|.....:.....|.:.:.....|:.|..||.:.:|||||||.|||.|.||||:..|..
Mouse   488 LTQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRSKRNFILDQCNVYNSGQRRKLLLFKT 552

  Fly   810 FKRIAVVCIPSEDELKRRI-AEKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGD 873
            |.|..||.:|:|::.|||: ..||.:|:  .|.||.:..::|||:||. :..:.|::.|.||..:
Mouse   553 FSRKVVVVVPNEEDWKRRLELRKEVEGD--DVPESIMLEMKANFSLPE-KCDYMDEVTYGELEKE 614

  Fly   874 EAKSEVKKYNEKGKKAIDAERSRDKRSRGSRDNYRRDDRN-RNRYNDDRRRDY-GGQRHESRWSD 936
            ||:..|.||.|:.:|.:.....|..         ||::|| |||.|..|.:.| ||||
Mouse   615 EAQPIVTKYKEEARKLLPPSEKRTN---------RRNNRNKRNRQNRSRGQGYVGGQR------- 663

  Fly   937 SRRGGGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQNWVQNSRRSGYD---DRGYGGGGSG--SR 996
                               ||||||      :.|||.|.|:..|.||.   || |.|....  ||
Mouse   664 -------------------RGYDNR------AYGQQYWGQSGNRGGYRNFYDR-YRGDYERFYSR 702

  Fly   997 GYD-NRNRGY 1005
            .|: ||.|.|
Mouse   703 DYEYNRYRDY 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251	16/33 (48%)
		SPRY_hnRNP	300..480	CDD:293942	69/184 (38%)
		PHA02664	<529..659	CDD:177447	0/129 (0%)
		AAA_33	709..855	CDD:290396	59/146 (40%)
		NK	709..>836	CDD:302627	52/127 (41%)
		DUF1777	1033..>1104	CDD:285811
Hnrnpul2	NP_001074665.1	SAP	3..37	CDD:128789	16/33 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..239		61/271 (23%)
		SPRY_hnRNP	244..415	CDD:293942	69/182 (38%)
		NK	452..>634	CDD:302627	72/184 (39%)
		AAA_33	452..597	CDD:290396	59/146 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..664		17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5115
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2136
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001523
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X963
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	8.010