DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and RNF123

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_071347.2	Gene:	RNF123 / 63891	HGNCID:	21148	Length:	1314	Species:	Homo sapiens

Alignment Length:	331	Identity:	70/331 - (21%)
Similarity:	120/331 - (36%)	Gaps:	87/331 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 SHSRSKSRSRSGSRSSKHRGSVGDK-------------RESKAAAEERTVPEDEPTIEENKVGLS 303
            |.||...|..|.:..|:..|.|.:|             ..:..||..|. |.:...:.|:...|.
Human     9 SFSRKSYRLTSDAEKSRVTGIVQEKLLNDYLNRIFSSSEHAPPAATSRK-PLNFQNLPEHLDQLL 72

  Fly   304 WLDSD-------LHLRIDPTT--------FASAKPLTSEIYSLIWSGARANYG-------VREGK 346
            .:|::       :..|:.|:|        |.....:..::..:|   ..:|:|       |.:||
Human    73 QVDNEEEESQGQVEGRLGPSTVVLDHTGGFEGLLLVDDDLLGVI---GHSNFGTIRSTTCVYKGK 134

  Fly   347 VCFEVRLSEESVPE-----NSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQS 406
            ..:||.:|.:.:.:     .|..|..|..|                |:..:|:.|.....:....
Human   135 WLYEVLISSQGLMQIGWCTISCRFNQEEGV----------------GDTHNSYAYDGNRVRKWNV 183

  Fly   407 EFTDYGKPYQLDDVIGCYLDLESEPCTINYTLNGEDLGVAFE-----------------FEKSI- 453
            ..|:|||.:...|::.|.:||:..  |:::.|||..||.|||                 |::|:
Human   184 TTTNYGKAWAAGDIVSCLIDLDDG--TLSFCLNGVSLGTAFENLSRGLGMAYFPAISLSFKESVA 246

  Fly   454 --LGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWK 516
              .|.....:|   ..||..|.:....:  ||.|:|.....|.....|....:....|.:..||:
Human   247 FNFGSRPLRYP---VAGYRPLQDPPSAD--LVRAQRLLGCFRAVLSVELDPVEGRLLDKESSKWR 306

  Fly   517 VLDEAT 522
            :..:.|
Human   307 LRGQPT 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251
		SPRY_hnRNP	300..480	CDD:293942	46/226 (20%)
		PHA02664	<529..659	CDD:177447
		AAA_33	709..855	CDD:290396
		NK	709..>836	CDD:302627
		DUF1777	1033..>1104	CDD:285811
RNF123	NP_071347.2	SPRY_RNF123	123..250	CDD:293940	32/144 (22%)
RNF123	NP_071347.2	zf-C3HC4_3	1250..1298	CDD:290631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810