DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and si:ch211-107m4.1

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_697747.4	Gene:	si:ch211-107m4.1 / 569278	ZFINID:	ZDB-GENE-081107-3	Length:	716	Species:	Danio rerio

Alignment Length:	1009	Identity:	225/1009 - (22%)
Similarity:	367/1009 - (36%)	Gaps:	354/1009 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMSRSPS 69
            :::|:||.:||..|:.|||:.||:||.||.||.:.:|     .||.||...
Zfish     5 EVKKLKVTELRAMLKERGLEAKGLKAELVVRLISAIE-----AENEPVKRG-------------- 50

  Fly    70 PVQAAPVAAEPVLDTLE---EE---EQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTE 128
                         ||:|   ||   |.|||.:...  .:..:|....:         .|..|.:.
Zfish    51 -------------DTVENVCEETITEPPEDSSAFL--SDEHKPCVRTQ---------SPVCASSS 91

  Fly   129 DTTVNQAVNEESQPEPEE------FDEKSETDDKQETIEEAVPAVVPQNEVADEP-----MEEDH 182
            :|::....::.:|.||::      .|..:..:....:..:|:...:.|..|..:|     .||:.
Zfish    92 NTSMKDFADQSTQTEPQQLCSCRLIDASAIAEPLTTSTLQAIEKRLQQTNVDPQPSVLRDAEENA 156

  Fly   183 -----------DAAPEEQE-----PTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKT 231
                       ...|:|||     |:...|.|:..|                     |||..|
Zfish   157 LSGGSLSALGISKEPQEQEQELYNPSDGHETVDSTP---------------------EDSREP-- 198

  Fly   232 AEETEPAAKPEDQPPERRKRSHSRSKSRSRSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIE 296
                       ::|.|.|.|.:...|            ...:.::.::....||...|.:||  |
Zfish   199 -----------EKPYEERGRDYYEFK------------EDILYNRAKTPEPVEELPEPVEEP--E 238

  Fly   297 ENKVGLSWLDSDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEV----RLSEES 357
            .:.|.|...:.|||..:| :..:|.:||..|.:.|:|||.|..:|..:|||.||.    |||..:
Zfish   239 VDFVRLDSYNGDLHFEVD-SNGSSGQPLFWEKFPLLWSGCRMTHGYCQGKVGFEAKFVKRLSAPA 302

  Fly   358 VPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIG 422
            :..|     :.|.:...|||:|:..|||.|||.|.|:|:...|...|..:...:|:|:...||||
Zfish   303 LNTN-----NAPDLHVLRVGWSVDSSSLQLGEVELSYGFDGRGSIVTGGKEESFGEPFTEGDVIG 362

  Fly   423 CYLDL-ESEPCTINYTLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAE 486
            ||..: |:...|:::..||..|||||....|:||.: ||:||::.|.....||.
Zfish   363 CYAHIDETGEATLSFHKNGRSLGVAFHLNSSVLGGQ-ALYPHVLCKNCSVSVNL----------- 415

  Fly   487 RPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEK 551

Zfish   416 ----------------------------------------------------------------- 415

  Fly   552 AKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEK 616

Zfish   416 ----------------------------------------------------------------- 415

  Fly   617 ASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLE 681
                          |.|.|                                 ..|.|       .
Zfish   416 --------------DPDAP---------------------------------WYPFP-------A 426

  Fly   682 GYVLIGLVPVEKLVSGPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFIS 746
            |:..:..:|..:....|....|:.:|||:::||:||:||||||..|:.:|..|||:|:..::.::
Zfish   427 GFSALSTLPPGQRTRAPLPAASKSDCEVLMMVGMPGSGKTHWAQAHILQNPSKRYDLLSTNSILN 491

  Fly   747 KMTIDGASRKTVHKGRWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFK 811
            .|      |:.......:.:.:.....::.|..||..::||:||||.|:|.||||.||..|:.::
Zfish   492 CM------REPTGANHRELMLQQATQCVSQLIKIAAAKKRNYILDQANIYPSAQRHKMLCFHGYQ 550

  Fly   812 RIAVVCIPSEDELKRRIAEKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAK 876
            |.|||..|.::..:.|:.:::|: ....|:|:::...:.:||:| ::....:::.:.||..:||.
Zfish   551 RKAVVVFPPDEVWRSRLVQRQEQ-EGIAVQETSLLKAKVSFTVP-VQGQHLEEVMFVELNSEEAL 613

  Fly   877 SEVKKYNEKGKKAIDAERSRDKRSRGSRDN-YRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRG 940
            ..:.:|.|:.::.:.....|.|..:|.:.: .....|.|..|:  .|..|..|:... || |...
Zfish   614 KLLTQYKEEARRLLPTPPKRKKYRQGCQKHLIHHCGRRRGPYS--CRNHYTSQKAHG-WS-SPAF 674

  Fly   941 GGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQNW 974
            |...||||:.        ...|||.....||  |
Zfish   675 GQPYGYSSDP--------QRYRNYYRPYTGQ--W 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251	17/33 (52%)
		SPRY_hnRNP	300..480	CDD:293942	68/184 (37%)
		PHA02664	<529..659	CDD:177447	3/129 (2%)
		AAA_33	709..855	CDD:290396	48/145 (33%)
		NK	709..>836	CDD:302627	44/126 (35%)
		DUF1777	1033..>1104	CDD:285811
si:ch211-107m4.1	XP_697747.4	SAP	6..40	CDD:280251	17/33 (52%)
		SPRY_hnRNP	242..414	CDD:293942	66/178 (37%)
		AAA_33	454..593	CDD:290396	48/145 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8426
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001523
OrthoInspector	1	1.000	-	-		otm25316
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X963
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.100