DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and hnrnpua

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_694691.5	Gene:	hnrnpua / 566326	ZFINID:	ZDB-GENE-030131-3731	Length:	760	Species:	Danio rerio

Alignment Length:	1080	Identity:	248/1080 - (22%)
Similarity:	389/1080 - (36%)	Gaps:	394/1080 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMS 65
            |....::|:||.:|::||:.|.|..||:||.|:.||:|.::..|..|.|.
Zfish     1 MSAINVKKLKVNELKDELKKRSLSDKGLKADLMSRLQAALDEEALSGTNG--------------- 50

  Fly    66 RSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTEDT 130
                                 .|.:.||                         ..:||....|:.
Zfish    51 ---------------------SERRYED-------------------------GGDPAGKDLEED 69

  Fly   131 TVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQEPTQTE 195
            .|.:::.||   |.:..:.::|.||..|..||         :...|..:.|.||..::.:....|
Zfish    70 PVGESMEEE---EEDGGNAEAEHDDIMEEEEE---------DAGVEMDKSDEDALLKDDDGDDDE 122

  Fly   196 EPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRSHSRSKSRS 260
            :...||..|..||..:.:.|..|.|..:.....                  :||:..|.|:
Zfish   123 DEEMEKFDEDDVALDKGDADKDKKDEQKNKKGV------------------KRRRDEHGRA---- 165

  Fly   261 RSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHLRIDPTTFASAKPLT 325
                    :...:.:::.|:|.:.:..:.|::...::..|.|...:.|||.::....: ||..||
Zfish   166 --------YFEFIEERKYSRAKSPQPPLEEEDEEFDDTTVCLDTYNCDLHFKVSRDRY-SASSLT 221

  Fly   326 SEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHV--RGFR-----VGFSMPKS 383
            .|.::.:|:|.|.:|||.:||.|||:::.|: :|..        |:  :|..     ||:|:..|
Zfish   222 MESFAYLWAGGRGSYGVDKGKACFEMKVIEK-IPVK--------HISSKGIEDHDVLVGWSLANS 277

  Fly   384 SLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESEPCTINYTLNGEDLGVAFE 448
            |.||||..:|:.:..|.:|.:.:...|||:.:..:||:||:::.:.....|:::.||||||.||.
Zfish   278 SYLLGEEAYSYAFSMTAKKTSNAVTEDYGETFDENDVVGCFINFDGAEVEISFSKNGEDLGKAFT 342

  Fly   449 FEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGE 513
            ..|..| :...||||::........||.
Zfish   343 VSKDEL-KGKPLFPHVLCHNCAVEFNFG------------------------------------- 369

  Fly   514 KWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKP 578
                                           :.|.|..|:.|
Zfish   370 -------------------------------QQESPFFAQPD----------------------- 380

  Fly   579 ESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKT 643

Zfish   381 ----------------------------------------------------------------- 380

  Fly   644 DGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQRVGSRKECE 708
                                                  |:.|:..:||...:.||:...::|:||
Zfish   381 --------------------------------------GFTLLQQIPVHDRIRGPKGPENKKDCE 407

  Fly   709 VILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASR--KTVHKGRWDKVYEICL 771
            ||::|||||:|||.|..||...|..| |.::|.|..:.||.|....|  |.|     .|:.||.|
Zfish   408 VIVVVGLPGSGKTEWVTKHTEANPGK-YNILGTDTILEKMMISTLKRQMKDV-----TKLLEISL 466

  Fly   772 NS---LAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELKRRIAEKEE 833
            .:   |....:||.:::||:|||||||.|||::|||..|..|:|.|||..|:::|.|:|..:|.|
Zfish   467 RAPLFLGKFIEIAARKKRNYILDQTNVSASARKRKMCLFAGFQRKAVVVCPTDEEYKKRTLKKAE 531

  Fly   834 KGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGK------KAIDA 892
            . :...|.|..|...:..::|| :|...|.::.|.||..:|....:::|.|..|      |.|.|
Zfish   532 T-DGKKVPEQAIRKTKRIYSLP-VEGDCFSEVLYVELQKEEVAKLLEQYKEDSKICSLEPKPIQA 594

  Fly   893 ---ERSRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGG 954
               .:.|..:.||.::.:.|                               ||.||.:...||.|
Zfish   595 GVQSKRRSSKGRGGKNMFNR-------------------------------GGEGGLAQRGGGRG 628

  Fly   955 SRGYDNRRNYNS---GSGGQQNWVQNSRRSGYD------DRGYGGGGSGSRGYDNRNRGYAGGSG 1010
              |:.:|.|:..   ..||       .||...|      .|.....||.|||....|||.|...|
Zfish   629 --GFPHRGNFMGVPIPRGG-------FRRPPIDFLPPHAFREVFSRGSFSRGMVMPNRGGAPRPG 684

  Fly  1011 GGGGGGGGGGGG--------GGQQNWMQNNRRSGYDDRGY 1042
            .|.|..|..||.        ||..|:.|..|..|.::||:
Zfish   685 PGRGNMGNRGGAMHREHMGHGGGGNFNQKFRGRGGNNRGF 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251	16/33 (48%)
		SPRY_hnRNP	300..480	CDD:293942	61/186 (33%)
		PHA02664	<529..659	CDD:177447	4/129 (3%)
		AAA_33	709..855	CDD:290396	61/150 (41%)
		NK	709..>836	CDD:302627	58/131 (44%)
		DUF1777	1033..>1104	CDD:285811	4/10 (40%)
hnrnpua	XP_694691.5	SAP	6..40	CDD:128789	16/33 (48%)
		SPRY_hnRNP	197..372	CDD:293942	61/253 (24%)
		NK	408..562	CDD:302627	65/161 (40%)
		AAA_33	408..552	CDD:290396	61/150 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5203
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1871
OMA	1	1.010	-	-		QHG47565
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001523
OrthoInspector	1	1.000	-	-		otm25316
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X963
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	10.020