DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and Hnrnpul2

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_001292149.1	Gene:	Hnrnpul2 / 309197	RGDID:	1562784	Length:	745	Species:	Rattus norvegicus

Alignment Length:	1046	Identity:	277/1046 - (26%)
Similarity:	398/1046 - (38%)	Gaps:	380/1046 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVE----------GGAGDGENAPVTPSRRQR 59
            :::::||.:||:|||.||||::|:|..|.:||:..::          ||||.|
  Rat     2 EVKRLKVTELRSELQRRGLDSRGLKMDLAQRLQEALDAEMLEDEAGVGGAGPG------------ 54

  Fly    60 RTRSMSRSPSPVQAAPVAAEPVLDTLE-EEEQPEDKTVPQPEPESEQPAAE---------PEPEQ 114
              .:....|.||.|:  ...|..|..| :||:.||:.....|.:.|.|.|:         |||.:
  Rat    55 --GACKAEPRPVAAS--GGGPGGDEEEDDEEEEEDEEALLEEEDEEPPPAQALGQAAPPPPEPPE 115

  Fly   115 SEPEEAEPAAA--VTEDTTVNQAVNEESQPEPEEFDE-KSETDDKQETIEEAVPAVVPQNEVADE 176
            :...||||.|:  ..|.|..:..||     ..||.|. |.|.|
  Rat   116 TSAMEAEPEASDIPAEATAGSGGVN-----GGEEHDNGKGEED---------------------- 153

  Fly   177 PMEEDHDAAPEEQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKP 241
                    .|||:...:|  |..|.|.:..|.|...:.||:|                    :||
  Rat   154 --------GPEERSGDET--PGSEAPGDKAVEEQGDDQDSEK--------------------SKP 188

  Fly   242 EDQPPERR--------KRSHSRSKSRSRSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIEEN 298
            .....|||        |..|.|:....|..:..|:.:.....:.|:|...|::|:
  Rat   189 AGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPPPPEEEAKDEEEDQTL---------- 243

  Fly   299 KVGLSWLDSDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSE-----ESV 358
             |.|....||||.:|....: ..:||.||.:..:|||||:.|||.:||||||.::::     |..
  Rat   244 -VNLDTYTSDLHFQISKDRY-GGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEGC 306

  Fly   359 PENSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGC 423
            .|          |...|||:|:..|...|||.|.|:|:...|.||...:|.::|:.:..:|||||
  Rat   307 TE----------VSLLRVGWSIDFSCSQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGC 361

  Fly   424 YLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERP 488
            :.:.|:....::::.|||||||||...|..||:. ||.||::.|.....:||...|
  Rat   362 FANFETGEVELSFSKNGEDLGVAFRISKESLGDR-ALLPHVLCKNCVIELNFGQKE--------- 416

  Fly   489 TRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAK 553

  Rat   417 ----------------------------------------------------------------- 416

  Fly   554 EDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKAS 618

  Rat   417 ----------------------------------------------------------------- 416

  Fly   619 EDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGY 683
                                                            |...|.|       |.:
  Rat   417 ------------------------------------------------EPFFPPP-------EEF 426

  Fly   684 VLIGLVPVEKLVSGPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKM 748
            |.|..||||:.|.......:.:||||||:|||||:|||.||.|:..||.:|||.::|.:..:::|
  Rat   427 VFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAETVLTQM 491

  Fly   749 TIDGASRKTVHKGRWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRI 813
            .:.|.....:.....|.:.:.....|:.|..||.:.:|||||||.|||.|.||||:..|..|.|.
  Rat   492 RMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRSKRNFILDQCNVYNSGQRRKLLLFKTFSRK 556

  Fly   814 AVVCIPSEDELKRRI-AEKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKS 877
            .||.:|:|::.|:|: ..||.:|:  .|.||.:..::|||:||. :..:.|::.|.||..:||:.
  Rat   557 VVVVVPNEEDWKKRLELRKEVEGD--DVPESIMLEMKANFSLPE-KCDYMDEVTYGELEKEEAQP 618

  Fly   878 EVKKYNEKGKKAIDAERSRDKRSRGSRDNYRRDDRN-RNRYNDDRRRDY-GGQRHESRWSDSRRG 940
            .|.||.|:.:|.:.....|..         ||::|| |||.|..|.:.| ||||
  Rat   619 IVTKYKEEARKLLPPSEKRTN---------RRNNRNKRNRQNRSRGQGYVGGQR----------- 663

  Fly   941 GGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQNWVQNSRRSGYD---DRGYGGGGSG--SRGYD- 999
                           ||||||      :.|||.|.|:..|.||.   || |.|....  ||.|:
  Rat   664 ---------------RGYDNR------AYGQQYWGQSGNRGGYRNFYDR-YRGDYERFYSRDYEY 706

  Fly  1000 NRNRGY 1005
            ||.|.|
  Rat   707 NRYRDY 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251	16/33 (48%)
		SPRY_hnRNP	300..480	CDD:293942	69/184 (38%)
		PHA02664	<529..659	CDD:177447	0/129 (0%)
		AAA_33	709..855	CDD:290396	60/146 (41%)
		NK	709..>836	CDD:302627	53/127 (42%)
		DUF1777	1033..>1104	CDD:285811
Hnrnpul2	NP_001292149.1	SAP	3..37	CDD:128789	16/33 (48%)
		SPRY_hnRNP	244..415	CDD:293942	69/182 (38%)
		NK	452..>634	CDD:302627	73/184 (40%)
		AAA_33	452..597	CDD:290396	60/146 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	132	1.000	Domainoid score	I4973
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2064
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001523
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12381
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X963
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	9.010