DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG30122 and Hnrnpul1

DIOPT Version :10

Sequence 1:NP_001163196.1 Gene:CG30122 / 37146 FlyBaseID:FBgn0050122 Length:1272 Species:Drosophila melanogaster
Sequence 2:NP_659171.1 Gene:Hnrnpul1 / 232989 MGIID:2443517 Length:859 Species:Mus musculus


Alignment Length:1306 Identity:321/1306 - (24%)
Similarity:470/1306 - (35%) Gaps:503/1306 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMS 65
            |||.:|   ||.:||.|||.|||||:|:||.|.|||.|.:|                        
Mouse     1 MDVRRL---KVNELREELQRRGLDTRGLKAELAERLLAALE------------------------ 38

  Fly    66 RSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVP---QPEPESE-----QPAAEPEPEQSEPEEAEP 122
                       |.||  :...|.|..:|..:|   ..|.|:|     :..|:|.|...:|     
Mouse    39 -----------AEEP--EDERELEADDDPGLPGHNNEEVETEGGSELEGTAQPPPPGLQP----- 85

  Fly   123 AAAVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPM-----EEDH 182
                              .|||..:   |..|.     ...:..:..||:..:.|:     |..:
Mouse    86 ------------------HPEPGGY---SGPDG-----HYVMDNITRQNQFYETPVIKQENESSY 124

  Fly   183 DAAPEEQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPE 247
            |..|.:.||.|.             ..|                  |:...|.:..|.|...|||
Mouse   125 DRRPLDMEPQQQ-------------VYH------------------PELKTEMKQEAPPSFLPPE 158

  Fly   248 RRKRSHSRSKSRSRSGS-RSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHL 311
            ..:....|.:.::|... ..::.||....:.:.:..:.:....|||...::..|.:...:.|||.
Mouse   159 ASQLKTDRPQFQNRKRPFEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHF 223

  Fly   312 RIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRV 376
            :: ....:|..|||.|.::.:||||||:||||.|:||||::::||...::......:|||  .|:
Mouse   224 KV-ARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHV--VRI 285

  Fly   377 GFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLE-SEPCTINYTLNG 440
            |:|:...|..|||...|:||..||:|:|.|.|.:||..:..:|||||:.|.| .....:::|.||
Mouse   286 GWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNG 350

  Fly   441 EDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDD 505
            :.:|:||..:|..||.: ||:||::.|......||                              
Mouse   351 KWMGIAFRIQKEALGGQ-ALYPHVLVKNCAVEFNF------------------------------ 384

  Fly   506 DKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVE 570
                                                                             
Mouse   385 ----------------------------------------------------------------- 384

  Fly   571 APAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGP 635
              .:.|:|                                                         
Mouse   385 --GQRAEP--------------------------------------------------------- 390

  Fly   636 SPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQR 700
                                          |..|:|          |:..|..:|:.:.:.|...
Mouse   391 ------------------------------YCSVLP----------GFTFIQHLPLSERIRGTIG 415

  Fly   701 VGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDK 765
            ..|:.|||::::||||.||||.||.||.|.|..|:|.::|.:|.:.||.:.|..|:..:.||||.
Mouse   416 PKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDV 480

  Fly   766 VYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELK-RRIA 829
            :.:.....|..|..||.:::||:||||||||.|||||||:.|..|:|.|:|..|::::|| |.:.
Mouse   481 LIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTVK 545

  Fly   830 EKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAIDAER 894
            ..:|:|.  .|.:..:..::||||||.:. .:.|::.:.||..:||...|::|||:|:||     
Mouse   546 RTDEEGK--DVPDHAVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKA----- 602

  Fly   895 SRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGYD 959
                                            |...|.|: |||    |||:....||||.:.||
Mouse   603 --------------------------------GPPPEKRF-DSR----GGGFRGRGGGGGFQRYD 630

  Fly   960 NRRNYNSGSGGQQNWVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGGGGG----GG 1020
            ||     |..|       ..|.|:.:|| ||||||               ||||...||    ||
Mouse   631 NR-----GPPG-------GNRGGFQNRG-GGGGSG---------------GGGGNYRGGFNRSGG 667

  Fly  1021 GGGGQQNWMQNNRRSGYDDRGYGSSRDYRDRDRGNDRSRMGSNDRNRGSSQS------------- 1072
            ||..|..|..||                ||.:..|:|     .:.||...|.             
Mouse   668 GGYNQNRWGNNN----------------RDNNNSNNR-----GNYNRAPQQQPPPQQPPPPQPPP 711

  Fly  1073 -------SYR-----SGGGTHQQRDFRPGHRDTKEDSRGGYERSAGQSLPKYGNNTAVGGGYDQ- 1124
                   ||.     .|..::.:....||             .||..|.|...:.|.....|.| 
Mouse   712 QQPPPPPSYSPARNPPGASSYNKNSNIPG-------------SSANTSTPTVSSYTPPQPSYSQP 763

  Fly  1125 -YKQQGGAPGGGKA-------SLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAA 1181
             | .|||...|..|       ..:..:.:|..::.....|....|        :|.|.||     
Mouse   764 PY-NQGGYTQGYTAPPPPPPPPPAYNYGSYGPYNPAPYTPPPPPT--------AQTYPQP----- 814

  Fly  1182 GQQQYWAYNQMQTGYGNQQAWQSADPQQQQQWMSWWQQQQQGSGGAAAGNASGGSGVNVGGGAGN 1246
                  :|||.|              |..|||..::|.|.|..  ...||      .:.||.:|:
Mouse   815 ------SYNQYQ--------------QYAQQWSQYYQNQSQWP--PYYGN------YDYGGYSGS 851

  Fly  1247 NDGGAA 1252
            ..||.:
Mouse   852 TQGGTS 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG30122NP_001163196.1 SAP 6..40 CDD:460424 21/33 (64%)
PLN03124 8..>168 CDD:215591 40/167 (24%)
SPRY_hnRNP 300..480 CDD:293942 70/180 (39%)
PTZ00121 <520..>677 CDD:173412 5/156 (3%)
AAA_33 709..855 CDD:463952 63/146 (43%)
SF-CC1 1036..>1108 CDD:273721 14/96 (15%)
Hnrnpul1NP_659171.1 Necessary for interaction with HRMT1L1. /evidence=ECO:0000250 1..103 44/172 (26%)
PLN03124 2..>73 CDD:215591 34/110 (31%)
SAP 3..37 CDD:128789 22/36 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..131 26/162 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..206 12/59 (20%)
SPRY_hnRNP 212..389 CDD:293942 70/277 (25%)
Necessary for interaction with TP53. /evidence=ECO:0000250 214..859 252/991 (25%)
AAA_33 425..569 CDD:463952 63/145 (43%)
Necessary for interaction with BRD7 and transcriptional activation. /evidence=ECO:0000250 457..595 54/140 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..814 79/331 (24%)
5 X 3 AA repeats of R-G-G 613..661 28/79 (35%)
Necessary for transcription repression. /evidence=ECO:0000250 613..661 28/79 (35%)

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