DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30122 and Hnrnpul1

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	NP_659171.1	Gene:	Hnrnpul1 / 232989	MGIID:	2443517	Length:	859	Species:	Mus musculus

Alignment Length:	1306	Identity:	321/1306 - (24%)
Similarity:	470/1306 - (35%)	Gaps:	503/1306 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMS 65
            |||.:|   ||.:||.|||.|||||:|:||.|.|||.|.:|
Mouse     1 MDVRRL---KVNELREELQRRGLDTRGLKAELAERLLAALE------------------------ 38

  Fly    66 RSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVP---QPEPESE-----QPAAEPEPEQSEPEEAEP 122
                       |.||  :...|.|..:|..:|   ..|.|:|     :..|:|.|...:|
Mouse    39 -----------AEEP--EDERELEADDDPGLPGHNNEEVETEGGSELEGTAQPPPPGLQP----- 85

  Fly   123 AAAVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPM-----EEDH 182
                              .|||..:   |..|.     ...:..:..||:..:.|:     |..:
Mouse    86 ------------------HPEPGGY---SGPDG-----HYVMDNITRQNQFYETPVIKQENESSY 124

  Fly   183 DAAPEEQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPE 247
            |..|.:.||.|.             ..|                  |:...|.:..|.|...|||
Mouse   125 DRRPLDMEPQQQ-------------VYH------------------PELKTEMKQEAPPSFLPPE 158

  Fly   248 RRKRSHSRSKSRSRSGS-RSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHL 311
            ..:....|.:.::|... ..::.||....:.:.:..:.:....|||...::..|.:...:.|||.
Mouse   159 ASQLKTDRPQFQNRKRPFEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHF 223

  Fly   312 RIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRV 376
            :: ....:|..|||.|.::.:||||||:||||.|:||||::::||...::......:|||  .|:
Mouse   224 KV-ARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHV--VRI 285

  Fly   377 GFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLE-SEPCTINYTLNG 440
            |:|:...|..|||...|:||..||:|:|.|.|.:||..:..:|||||:.|.| .....:::|.||
Mouse   286 GWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNG 350

  Fly   441 EDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDD 505
            :.:|:||..:|..||.: ||:||::.|......||
Mouse   351 KWMGIAFRIQKEALGGQ-ALYPHVLVKNCAVEFNF------------------------------ 384

  Fly   506 DKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVE 570

Mouse   385 ----------------------------------------------------------------- 384

  Fly   571 APAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGP 635
              .:.|:|
Mouse   385 --GQRAEP--------------------------------------------------------- 390

  Fly   636 SPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQR 700
                                          |..|:|          |:..|..:|:.:.:.|...
Mouse   391 ------------------------------YCSVLP----------GFTFIQHLPLSERIRGTIG 415

  Fly   701 VGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDK 765
            ..|:.|||::::||||.||||.||.||.|.|..|:|.::|.:|.:.||.:.|..|:..:.||||.
Mouse   416 PKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDV 480

  Fly   766 VYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELK-RRIA 829
            :.:.....|..|..||.:::||:||||||||.|||||||:.|..|:|.|:|..|::::|| |.:.
Mouse   481 LIQQATQCLNRLIQIAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTVK 545

  Fly   830 EKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAIDAER 894
            ..:|:|.  .|.:..:..::||||||.:. .:.|::.:.||..:||...|::|||:|:||
Mouse   546 RTDEEGK--DVPDHAVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKA----- 602

  Fly   895 SRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGYD 959
                                            |...|.|: |||    |||:....||||.:.||
Mouse   603 --------------------------------GPPPEKRF-DSR----GGGFRGRGGGGGFQRYD 630

  Fly   960 NRRNYNSGSGGQQNWVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGGGGG----GG 1020
            ||     |..|       ..|.|:.:|| ||||||               ||||...||    ||
Mouse   631 NR-----GPPG-------GNRGGFQNRG-GGGGSG---------------GGGGNYRGGFNRSGG 667

  Fly  1021 GGGGQQNWMQNNRRSGYDDRGYGSSRDYRDRDRGNDRSRMGSNDRNRGSSQS------------- 1072
            ||..|..|..||                ||.:..|:|     .:.||...|.
Mouse   668 GGYNQNRWGNNN----------------RDNNNSNNR-----GNYNRAPQQQPPPQQPPPPQPPP 711

  Fly  1073 -------SYR-----SGGGTHQQRDFRPGHRDTKEDSRGGYERSAGQSLPKYGNNTAVGGGYDQ- 1124
                   ||.     .|..::.:....||             .||..|.|...:.|.....|.|
Mouse   712 QQPPPPPSYSPARNPPGASSYNKNSNIPG-------------SSANTSTPTVSSYTPPQPSYSQP 763

  Fly  1125 -YKQQGGAPGGGKA-------SLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAA 1181
             | .|||...|..|       ..:..:.:|..::.....|....|        :|.|.||
Mouse   764 PY-NQGGYTQGYTAPPPPPPPPPAYNYGSYGPYNPAPYTPPPPPT--------AQTYPQP----- 814

  Fly  1182 GQQQYWAYNQMQTGYGNQQAWQSADPQQQQQWMSWWQQQQQGSGGAAAGNASGGSGVNVGGGAGN 1246
                  :|||.|              |..|||..::|.|.|..  ...||      .:.||.:|:
Mouse   815 ------SYNQYQ--------------QYAQQWSQYYQNQSQWP--PYYGN------YDYGGYSGS 851

  Fly  1247 NDGGAA 1252
            ..||.:
Mouse   852 TQGGTS 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251	21/33 (64%)
		SPRY_hnRNP	300..480	CDD:293942	70/180 (39%)
		PHA02664	<529..659	CDD:177447	2/129 (2%)
		AAA_33	709..855	CDD:290396	63/146 (43%)
		NK	709..>836	CDD:302627	57/127 (45%)
		DUF1777	1033..>1104	CDD:285811	12/95 (13%)
Hnrnpul1	NP_659171.1	Necessary for interaction with HRMT1L1. /evidence=ECO:0000250	1..103		44/172 (26%)
		SAP	3..37	CDD:128789	22/36 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..131		26/162 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..206		12/59 (20%)
		SPRY_hnRNP	212..389	CDD:293942	70/277 (25%)
		Necessary for interaction with TP53. /evidence=ECO:0000250	214..859		252/991 (25%)
		AAA_33	424..569	CDD:290396	63/146 (43%)
		NK	424..>562	CDD:302627	59/139 (42%)
		Necessary for interaction with BRD7 and transcriptional activation. /evidence=ECO:0000250	457..595		54/140 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	595..814		79/331 (24%)
		5 X 3 AA repeats of R-G-G	613..661		28/79 (35%)
		Necessary for transcription repression. /evidence=ECO:0000250	613..661		28/79 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5115
eggNOG	1	0.900	-	-		E1_KOG2242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	367	1.000	Inparanoid score	I2136
Isobase	1	0.950	-	0	Normalized mean entropy	S6084
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001523
OrthoInspector	1	1.000	-	-		otm43224
orthoMCL	1	0.900	-	-		OOG6_106467
Panther	1	1.100	-	-	LDO	PTHR12381
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3099
SonicParanoid	1	1.000	-	-		X963
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.890