Protein Alignment CG30122 and HNRNPUL2

DIOPT Version :10

• Sequence 1: NP_001163196.1
• Gene: CG30122 / 37146
• FlyBaseID: FBgn0050122
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_001073027.1
• Gene: HNRNPUL2 / 221092
• HGNCID: 25451
• Length: 747
• Species: Homo sapiens
• Alignment Length: 1056
• Identity: 276/1056 - (26%)
• Similarity: 395/1056 - (37%)
• Gaps: 398/1056 - (37%)

  Fly     5 KLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVE----------GGAGDGENAPVTPSRRQR 59
            :::::||.:||:|||.||||::|:|..|.:||:..::          ||||.|
Human     2 EVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPG------------ 54

  Fly    60 RTRSMSRSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAA 124
              .:....|.||.|:  ...|..|..|:||:         |.|.|:...|.|.|:..|.
Human    55 --GACKAEPRPVAAS--GGGPGGDEEEDEEE---------EEEDEEALLEDEDEEPPPA------ 100

  Fly   125 AVTEDTTVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQ 189
                     ||:.:.:||.||                   |......|.|.||     ||:
Human   101 ---------QALGQAAQPPPE-------------------PPEAAAMEAAAEP-----DAS---- 128

  Fly   190 EPTQTEEPVEEKPAESTVAEHQSN-GDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRSH 253
                      |||||:|......| |:.|.:...|||....::.:||..:..|.|:..|.:....
Human   129 ----------EKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQ 183

  Fly   254 SRSKSRSRSGSRSSKHRGSVGDKRESKAAAEER----------------------TVPEDEPTIE 296
            .         |..||..||.|::|..|...:|:                      ..||:|...|
Human   184 D---------SEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDE 239

  Fly   297 ENK---VGLSWLDSDLHLRIDPTTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSE--- 355
            |..   |.|....||||.::....: ..:||.||.:..:|||||:.|||.:||||||.::::
Human   240 EEDQTLVNLDTYTSDLHFQVSKDRY-GGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLP 303

  Fly   356 --ESVPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLD 418
              |...|          |...|||:|:..|...|||.|.|:|:...|.||...:|.::|:.:..:
Human   304 MKEGCTE----------VSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGEN 358

  Fly   419 DVIGCYLDLESEPCTINYTLNGEDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLV 483
            |||||:.:.|:|...::::.|||||||||...|..|.:. ||.||::.|.....:||...|
Human   359 DVIGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADR-ALLPHVLCKNCVVELNFGQKE---- 418

  Fly   484 NAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAED 548
                                                                             
Human   419 ----------------------------------------------------------------- 418

  Fly   549 PEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQAN 613
                                                                             
Human   419 ----------------------------------------------------------------- 418

  Fly   614 DEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAA 678
                                                                 |...|.|
Human   419 -----------------------------------------------------EPFFPPP----- 425

  Fly   679 LLEGYVLIGLVPVEKLVSGPQRVGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDA 743
              |.:|.|..||||:.|.......:.:||||||:|||||:|||.||.|:..||.:|||.::|.:.
Human   426 --EEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAET 488

  Fly   744 FISKMTIDGASRKTVHKGRWDKVYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFN 808
            .:::|.:.|.....:.....|.:.:.....|:.|..||.:.:|||||||.|||.|.||||:..|.
Human   489 VLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNVYNSGQRRKLLLFK 553

  Fly   809 DFKRIAVVCIPSEDELKRRI-AEKEEKGNAFTVKESTINNLRANFTLPSLEFGWFDDINYTELTG 872
            .|.|..||.:|:|::.|:|: ..||.:|:  .|.||.:..::|||:||. :..:.|::.|.||..
Human   554 TFSRKVVVVVPNEEDWKKRLELRKEVEGD--DVPESIMLEMKANFSLPE-KCDYMDEVTYGELEK 615

  Fly   873 DEAKSEVKKYNEKGKKAIDAERSRDKRSRGSRDNYRRDDRN-RNRYNDDRRRDY-GGQRHESRWS 935
            :||:..|.||.|:.:|.:.....|..         ||::|| |||.|..|.:.| ||||
Human   616 EEAQPIVTKYKEEARKLLPPSEKRTN---------RRNNRNKRNRQNRSRGQGYVGGQR------ 665

  Fly   936 DSRRGGGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQNWVQNSRRSGYD----------DRGYGG 990
                                ||||||      :.|||.|.|...|.||.          ||.||
Human   666 --------------------RGYDNR------AYGQQYWGQPGNRGGYRNFYDRYRGDYDRFYG- 703

  Fly   991 GGSGSRGYD-NRNRGY 1005
                 |.|: ||.|.|
Human   704 -----RDYEYNRYRDY 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:460424	16/33 (48%)
		PLN03124	8..>168	CDD:215591	44/169 (26%)
		SPRY_hnRNP	300..480	CDD:293942	68/184 (37%)
		PTZ00121	<520..>677	CDD:173412	3/156 (2%)
		AAA_33	709..855	CDD:463952	60/146 (41%)
		SF-CC1	1036..>1108	CDD:273721
HNRNPUL2	NP_001073027.1	SAP	3..37	CDD:128789	16/33 (48%)
		PRK12678	6..>212	CDD:237171	76/292 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..242		65/288 (23%)
		SPRY_hnRNP	246..417	CDD:293942	68/182 (37%)
		AAA_33	454..599	CDD:463952	60/146 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	627..666		17/73 (23%)