Protein Alignment CG30122 and HNRNPUL1

DIOPT Version :10

• Sequence 1: NP_001163196.1
• Gene: CG30122 / 37146
• FlyBaseID: FBgn0050122
• Length: 1272
• Species: Drosophila melanogaster
• Sequence 2: NP_001426097.1
• Gene: HNRNPUL1 / 11100
• HGNCID: 17011
• Length: 866
• Species: Homo sapiens
• Alignment Length: 1284
• Identity: 326/1284 - (25%)
• Similarity: 468/1284 - (36%)
• Gaps: 469/1284 - (36%)

  Fly     1 MDVAKLEKMKVVDLRNELQSRGLDTKGVKAVLVERLRAYVEGGAGDGENAPVTPSRRQRRTRSMS 65
            |||.:|   ||.:||.|||.|||||:|:||.|.|||:|.:|....|.|             |.:.
Human     1 MDVRRL---KVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDE-------------RELD 49

  Fly    66 RSPSPVQAAPVAAEPVLDTLEEEEQPEDKTVPQPEPESEQPAAEPEPEQSEPEEAEPAAAVTEDT 130
            ....|.:...:..|     :|.|...|.:...||.|...||.|||
Human    50 ADDEPGRPGHINEE-----VETEGGSELEGTAQPPPPGLQPHAEP-------------------- 89

  Fly   131 TVNQAVNEESQPEPEEFDEKSETDDKQETIEEAVPAVVPQNEVADEPMEEDHDAAPEEQEPTQTE 195
                  ...|.|:.                ..|:..:..||:..|..:.:..:.:..|:.|.:.|
Human    90 ------GGYSGPDG----------------HYAMDNITRQNQFYDTQVIKQENESGYERRPLEME 132

  Fly   196 EPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRSHSRSKSRS 260
            :....:|...|           :|......|..|..|.:    .||:.|..:.|||.:..::.|.
Human   133 QQQAYRPEMKT-----------EMKQGAPTSFLPPEASQ----LKPDRQQFQSRKRPYEENRGRG 182

  Fly   261 RSGSRSSKHRGSVGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHLRIDPTTFASAKPLT 325
            ....|..: ||     |..:..||     |||...::..|.:...:.|||.:: ....:|..|||
Human   183 YFEHREDR-RG-----RSPQPPAE-----EDEDDFDDTLVAIDTYNCDLHFKV-ARDRSSGYPLT 235

  Fly   326 SEIYSLIWSGARANYGVREGKVCFEVRLSEESVPENSHYFRDEPHVRGFRVGFSMPKSSLLLGEA 390
            .|.::.:||||||:||||.|:||||::::||...::......:|||  .|:|:|:...|..|||.
Human   236 IEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHV--VRIGWSLDSCSTQLGEE 298

  Fly   391 EHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLE-SEPCTINYTLNGEDLGVAFEFEKSIL 454
            ..|:||..||:|:|.|.|.:||..:..:|||||:.|.| .....:::|.||:.:|:||..:|..|
Human   299 PFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEAL 363

  Fly   455 GEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDDDKDDNDGEKWKVLD 519
            |.: ||:||::.|......||
Human   364 GGQ-ALYPHVLVKNCAVEFNF-------------------------------------------- 383

  Fly   520 EATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVEAPAEAAKPESEATE 584
                                                                 .:.|:|
Human   384 -----------------------------------------------------GQRAEP------ 389

  Fly   585 ASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGPSPNKRPKTDGDSEK 649
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   650 AESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQRVGSRKECEVILLVG 714
                            |..|:|          |:..|..:|:.:.:.|.....|:.|||::::||
Human   390 ----------------YCSVLP----------GFTFIQHLPLSERIRGTVGPKSKAECEILMMVG 428

  Fly   715 LPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDKVYEICLNSLAALED 779
            ||.||||.||.||.|.|..|:|.::|.:|.:.||.:.|..|:..:.||||.:.:.....|..|..
Human   429 LPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQ 493

  Fly   780 IAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELK-RRIAEKEEKGNAFTVKES 843
            ||.:::||:||||||||.|||||||:.|..|:|.|:|..|::::|| |.|...:|:|.  .|.:.
Human   494 IAARKKRNYILDQTNVYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDEEGK--DVPDH 556

  Fly   844 TINNLRANFTLPSLEFGWFDDINYTELTGDEAKSEVKKYNEKGKKAIDAERSRDKRSRGSRDNYR 908
            .:..::||||||.:. .:.|::.:.||..:||...|::|||:|:||
Human   557 AVLEMKANFTLPDVG-DFLDEVLFIELQREEADKLVRQYNEEGRKA------------------- 601

  Fly   909 RDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGYDNRRNYNSGSGGQQN 973
                              |...|.|: |:|   ||||:....||||.:.|:|
Human   602 ------------------GPPPEKRF-DNR---GGGGFRGRGGGGGFQRYEN------------- 631

  Fly   974 WVQNSRRSGYDDRGYGGGGSGSRGYDNRNRGYAGGSGGGGGGGGG----GGGGGGQQNWMQNNRR 1034
                        ||..||..|  |:.||    .|||||||...||    ||||..|..|..||
Human   632 ------------RGPPGGNRG--GFQNR----GGGSGGGGNYRGGFNRSGGGGYSQNRWGNNN-- 676

  Fly  1035 SGYDDRGYGSSRDYRDRDRGNDRSRMGSNDRNRGSSQS--------------------SYR---- 1075
                          ||.:..|:|   ||  .||...|.                    ||.
Human   677 --------------RDNNNSNNR---GS--YNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARN 722

  Fly  1076 -SGGGTHQQRDFRPG-HRDTKEDSRGGYERSAGQSL--------PKYGNNTAVGGGYDQ-YKQQG 1129
             .|..|:.:....|| ..:|...:...|  |..||.        |.|.......|||.| |....
Human   723 PPGASTYNKNSNIPGSSANTSTPTVSSY--SPPQSFGFFPSTFQPSYSQPPYNQGGYSQGYTAPP 785

  Fly  1130 GAPGGGKASLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAAGQQQYWAYNQMQT 1194
            ..|....|...|.:..|:........|...||           |.||           :|||.|
Human   786 PPPPPPPAYNYGSYGGYNPAPYTPPPPPTAQT-----------YPQP-----------SYNQYQ- 827

  Fly  1195 GYGNQQAWQSADPQQQQQWMSWWQQQQQG-------SGGAAAGNASGGS 1236
                         |..|||..::|.|.|.       ..|:.:||..||:
Human   828 -------------QYAQQWNQYYQNQGQWPPYYGNYDYGSYSGNTQGGT 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:460424	21/33 (64%)
		PLN03124	8..>168	CDD:215591	40/159 (25%)
		SPRY_hnRNP	300..480	CDD:293942	70/180 (39%)
		PTZ00121	<520..>677	CDD:173412	5/156 (3%)
		AAA_33	709..855	CDD:463952	64/146 (44%)
		SF-CC1	1036..>1108	CDD:273721	18/97 (19%)
HNRNPUL1	NP_001426097.1	Necessary for interaction with HRMT1L1	1..103		44/164 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..205		49/255 (19%)
		Necessary for interaction with BRD7 and transcriptional activation. /evidence=ECO:0000269|PubMed:12489984	456..594		55/140 (39%)
		5 X 3 AA repeats of R-G-G	612..658		26/79 (33%)
		Necessary for transcription repression	612..658		26/79 (33%)