DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30122 and hnrnpul1

DIOPT Version :9

Sequence 1:	NP_001163196.1	Gene:	CG30122 / 37146	FlyBaseID:	FBgn0050122	Length:	1272	Species:	Drosophila melanogaster
Sequence 2:	XP_002939432.2	Gene:	hnrnpul1 / 100498275	XenbaseID:	XB-GENE-940473	Length:	809	Species:	Xenopus tropicalis

Alignment Length:	1090	Identity:	289/1090 - (26%)
Similarity:	423/1090 - (38%)	Gaps:	369/1090 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 EQEPTQTEEPVEEKPAESTVAEHQSNGDSQKMDVDEEDSAAPKTAEETEPAAKPEDQPPERRKRS 252
            :||..|..:..:.:|||                 .......|..|.:||  .|.|...|..|..:
Frog    53 KQERDQGYDRYDRRPAE-----------------QPPPPLLPNMALKTE--FKQEQPDPGYRGPN 98

  Fly   253 HSRSKSRSRSGSRSSKHRGS--VGDKRESKAAAEERTVPEDEPTIEENKVGLSWLDSDLHLRIDP 315
            .:.::.:.::..|..:.||.  ...:.|.:|.:.:.:..:|:...:||.|.|...:||||.::|.
Frog    99 AASNQPQFQNRKRGFEDRGHGYYEHRDERRARSPQGSGFDDDDVFDENVVVLDNYNSDLHFKLDK 163

  Fly   316 TTFASAKPLTSEIYSLIWSGARANYGVREGKVCFEVRLSEE----SVPENSHYFRDEPHVRGFRV 376
            .. ....|||.|.::.:||||||.:||..|:||||::::|:    .:|.|    ..:|||  .||
Frog   164 DR-TVGYPLTIEGFAYLWSGARATHGVNRGRVCFEMKVTEKISVGHLPSN----EPDPHV--VRV 221

  Fly   377 GFSMPKSSLLLGEAEHSFGYCETGRKATQSEFTDYGKPYQLDDVIGCYLDLESE-PCTINYTLNG 440
            |:|:...|..|||...|:||..||:|::.|.|.:||:.:...||||||:|.||. ...::::.||
Frog   222 GWSLDSCSTQLGEEPFSYGYGGTGKKSSNSRFENYGETFAEHDVIGCYIDFESHGDIEMSFSKNG 286

  Fly   441 EDLGVAFEFEKSILGEEGALFPHIVTKGYEYLVNFSDTEQLLVNAERPTRKRRKPRKDEDKDKDD 505
            :.|||||...|..||.: ||||||:.|......||
Frog   287 QPLGVAFRVHKETLGSQ-ALFPHILVKNCTVEFNF------------------------------ 320

  Fly   506 DKDDNDGEKWKVLDEATADDDEVEKKDEDGKASSEKDEEEAEDPEKAKEDEAAPKTETEAETKVE 570
                  |::
Frog   321 ------GQR-------------------------------------------------------- 323

  Fly   571 APAEAAKPESEATEASETAETSTEKSSETAAVSNGDAAAEQANDEKASEDKKPSENNDEEDEDGP 635

Frog   324 ----------------------------------------------------------------- 323

  Fly   636 SPNKRPKTDGDSEKAESEKEKDRSQTTEDEYEDVVPEPRDTAALLEGYVLIGLVPVEKLVSGPQR 700
                                               |||..:|  :.|:..|..|...:.|.|.:.
Frog   324 -----------------------------------PEPFCSA--IPGFTFIQHVQPYERVRGTEP 351

  Fly   701 VGSRKECEVILLVGLPGAGKTHWAHKHVAENADKRYELIGPDAFISKMTIDGASRKTVHKGRWDK 765
            ..::.|||::::|||||||||.||.||.|.:.:|:|.::|.:|.:.||.:.|..|:..:.||||.
Frog   352 PKNKAECEILMMVGLPGAGKTTWAVKHAAAHPEKKYVILGTNAIMEKMRVMGLRRQRNYAGRWDV 416

  Fly   766 VYEICLNSLAALEDIAMKRRRNFILDQTNVYASAQRRKMKGFNDFKRIAVVCIPSEDELKRRIAE 830
            :.:.....|..|..||.:|:||:||||||||.:||:|||:.|..|:|.|::..|::.:|:.||.:
Frog   417 LIQQATQCLNRLIQIAARRKRNYILDQTNVYGTAQKRKMRPFEGFQRKAIIICPTDADLQDRIVK 481

  Fly   831 K-EEKGNAFTVKESTINNLRANFTLPSLEFGWF-DDINYTELTGDEAKSEVKKYNEKGKKAIDAE 893
            : :|:|.  .|.:|.:..::|||.||  |.|.| |::.|.||..::|:..|::|||:||:|
Frog   482 RTDEEGK--DVPDSAVLEMKANFALP--EPGDFLDEVIYVELQKEDAEPLVRQYNEEGKRA---- 538

  Fly   894 RSRDKRSRGSRDNYRRDDRNRNRYNDDRRRDYGGQRHESRWSDSRRGGGGGGYSSNSGGGGSRGY 958
                                             |...|.|:    ||.|||    ..|||..||
Frog   539 ---------------------------------GPPPEKRF----RGRGGG----PPGGGVGRG- 561

  Fly   959 DNRRNYNSGSGGQQNWVQNSRRSGYDDRGYGGGGSGSRG-------YDNRNRGYAGGSGGGGGG- 1015
                                     |.:|..|||.|..|       :|:...|:.||..|.|||
Frog   562 -------------------------DGKGRDGGGRGDGGARGDFQRFDSPLAGHRGGFQGRGGGN 601

  Fly  1016 --GGGGGGGGG---------QQNWMQNNRRSGYDDR-GYGSSRD----YRDRDRGNDRSRMGSND 1064
              ||..||.||         |..|..::..:|.:.| |||:|..    |....:|......|.:.
Frog   602 SAGGYRGGAGGFNRDGHNQPQSRWSGSSHDNGSESRGGYGASSQQQHYYPGGSQGGGYGNSGPSY 666

  Fly  1065 RNRGSSQSSYRSGGGTHQQRDFRPGHRDTKEDSRGGYERSAGQSL-PKYGNNTAVGGGYDQ-YKQ 1127
            .|.|.|.:|.:|....:.|         .:...:|||.:..|... |.| ||.:...||:| ...
Frog   667 GNSGPSSNSLQSAPNNYSQ---------GQNYGQGGYNQGGGSGYGPNY-NNQSYNQGYNQPPPN 721

  Fly  1128 QGGAPGGGKASLSGKWSTYSQHHQQQQAPQHQQTGIWQTQQQSQQYQQPQQAAAGQQQYWAYNQM 1192
            |..:|    |.||...|.|||.:||||. ..||.|.:|:|...|.....|..:.||.|
Frog   722 QSSSP----AQLSNSQSNYSQQYQQQQY-GGQQWGQYQSQASPQNPSSNQGPSHGQGQ------- 774

  Fly  1193 QTGYGNQQAWQSADPQQQQQWMSWWQQQQQGSGGAAAGNASGGSGVNVGG 1242
                     |.....|.|.||..|    ..||||.   :.||..|...||
Frog   775 ---------WSHGPSQGQGQWSQW----HYGSGGY---DPSGRYGSQGGG 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30122	NP_001163196.1	SAP	6..40	CDD:280251
		SPRY_hnRNP	300..480	CDD:293942	76/184 (41%)
		PHA02664	<529..659	CDD:177447	0/129 (0%)
		AAA_33	709..855	CDD:290396	61/146 (42%)
		NK	709..>836	CDD:302627	55/127 (43%)
		DUF1777	1033..>1104	CDD:285811	18/75 (24%)
hnrnpul1	XP_002939432.2	SPRY_hnRNP	148..325	CDD:293942	77/376 (20%)
hnrnpul1	XP_002939432.2	AAA_33	360..505	CDD:404546	61/146 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5182
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2053
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001523
OrthoInspector	1	1.000	-	-		otm48363
Panther	1	1.100	-	-	LDO	PTHR12381
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X963
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.150