DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and Fkbp6

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_030110810.1	Gene:	Fkbp6 / 94244	MGIID:	2137612	Length:	363	Species:	Mus musculus

Alignment Length:	334	Identity:	78/334 - (23%)
Similarity:	149/334 - (44%)	Gaps:	48/334 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNG 99
            :|.||:  ..|.|...|..::...||.|::.::|..|::...|:......   |.|.::|.|::
Mouse    45 NGIPPS--RDDCQSPYERLSQRMLDISGDRGVLKDIIREGTGDTVTPDAS---VLVKYSGYLEH- 103

  Fly   100 TVVENELNFQC--------HVGDYEVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESE 156
              ::...:..|        .:|:...:.|:::.|..::.||:::......:.||:||...
Mouse   104 --MDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRKGELARFLFKPAYAYGTLGCPP----- 161

  Fly   157 YLVPPDAHLTYEIELLDI----KYEEFADLKS-------FEILRKYGTRKKERANFFYKRSEFTT 210
             |:||:|.:.:||||:|.    :.::|..|.:       .:.:.|....::|..|:.::::.|..
Mouse   162 -LIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCD 225

  Fly   211 AIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDR-LIVYNNLAMTQIKIAAYDAALQ 274
            |...|:|||..|..|              |:..:.|.|:|.. |:|..||:...:|:.....||:
Mouse   226 AKVRYKRALLLLHRR--------------LATCEEQHLVEPAVLLVLLNLSFVYLKLDRPAMALR 276

  Fly   275 SVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREEH 339
            ..|..|.....|:|||:|.|:......:.:.|...|.:....:|.|..:.::|.:|....|....
Mouse   277 YGEQALLIDKRNAKALFRCGQACLLLTEYERARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVD 341

  Fly   340 NEKEMYQKM 348
            .|:||..:|
Mouse   342 REREMCHRM 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	21/99 (21%)
		TPR_11	196..284	CDD:290150	23/88 (26%)
		TPR repeat	196..220	CDD:276809	7/23 (30%)
		TPR repeat	252..282	CDD:276809	9/30 (30%)
		TPR_11	255..318	CDD:290150	16/62 (26%)
		TPR repeat	287..313	CDD:276809	7/25 (28%)
		TPR repeat	321..349	CDD:276809	7/28 (25%)
Fkbp6	XP_030110810.1	FKBP_C	86..176	CDD:365980	21/101 (21%)
		TPR_12	254..315	CDD:315987	17/60 (28%)
		TPR repeat	254..284	CDD:276809	9/29 (31%)
		TPR repeat	289..317	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810