DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and FKBP6

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_003593.3	Gene:	FKBP6 / 8468	HGNCID:	3722	Length:	327	Species:	Homo sapiens

Alignment Length:	338	Identity:	84/338 - (24%)
Similarity:	147/338 - (43%)	Gaps:	59/338 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GDGAPPASVSGDGQKAEEEDAEEECDILGNKQLIKRTIKK------APQDSFRRPIRGELVTVNF 92
            ||.||       ||...|..::...||.|::.::|..|::      ||..|         |.|.:
Human    13 GDDAP-------GQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDAS---------VLVKY 61

  Fly    93 TGKLDNGTVVENELNFQ-----CHVGDYEVIQGLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKE 152
            :|.|::.....:...|:     ..:|:...:.|:::.|..::.||:::......:.||:||...
Human    62 SGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPP- 125

  Fly   153 GESEYLVPPDAHLTYEIELLDI----KYEEFADLKS-------FEILRKYGTRKKERANFFYKRS 206
                 |:||:..:.:||||||.    :.::|..|.:       .:.:.|....::|..|:.::::
Human   126 -----LIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQN 185

  Fly   207 EFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLE-DRLIVYNNLAMTQIKIAAYD 270
            .|..|...|:|||..|..|...|:.              |.|:| .:|.|..||:.|.:|:....
Human   186 RFYDAKVRYKRALLLLRRRSAPPEE--------------QHLVEAAKLPVLLNLSFTYLKLDRPT 236

  Fly   271 AALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGAIKLLQKVATLEPENRAVQSDLARLFIKAR 335
            .||...|..|.....|:|||:|.|:......:.|.|...|.:....:|.|..:.::|.:|....|
Human   237 IALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYR 301

  Fly   336 REEHNEKEMYQKM 348
            .....||||:.:|
Human   302 DYVDKEKEMWHRM 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	20/96 (21%)
		TPR_11	196..284	CDD:290150	24/88 (27%)
		TPR repeat	196..220	CDD:276809	7/23 (30%)
		TPR repeat	252..282	CDD:276809	10/29 (34%)
		TPR_11	255..318	CDD:290150	18/62 (29%)
		TPR repeat	287..313	CDD:276809	8/25 (32%)
		TPR repeat	321..349	CDD:276809	8/28 (29%)
FKBP6	NP_003593.3	FKBP_C	51..140	CDD:306713	23/103 (22%)
		TPR	<164..315	CDD:223533	44/165 (27%)
		TPR 1	171..204		9/32 (28%)
		TPR 2	219..252		10/32 (31%)
		TPR repeat	221..247	CDD:276809	8/25 (32%)
		TPR repeat	252..282	CDD:276809	9/29 (31%)
		TPR 3	253..286		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810