DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zda and fkbp15a

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_009299868.1	Gene:	fkbp15a / 799923	ZFINID:	ZDB-GENE-060526-98	Length:	875	Species:	Danio rerio

Alignment Length:	462	Identity:	86/462 - (18%)
Similarity:	159/462 - (34%)	Gaps:	141/462 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTEKSSSSSFEDLTNAEDTK-------------DIRKVAAEEAASGD-------GAPPASVSGDG 46
            :|:||..:. .||..|.|.|             ...|:.:..|..|.       ||.||  ..|.
Zfish   323 ETDKSKCAQ-HDLDQAPDGKVEPKSECQIDSGPSKAKLISRIAKMGQPMLPFLIGAIPA--QPDP 384

  Fly    47 QKAEEEDAEE------------------------------ECDILGNKQLIKRTIKKAPQD---- 77
            ..:|.|||.|                              :.|.:.||:...:......||
Zfish   385 SDSETEDASESGLTCDPCPSHDSPSPKPAQIPCTSPPSLYQADAVQNKEAAPQAESNPAQDFQPC 449

  Fly    78 -------------SFRRPIRGELV---TVNFTGKLDNGTVVENELNFQCHVGDYEVIQGLDMVLP 126
                         ||....:.:.:   |.:.|..|.:.....|:          |::..::.:..
Zfish   450 SCRENPYFPPQLNSFTSIYQAQHIPYSTPDITSFLMSDARQHNK----------EILMAIEKLEH 504

  Fly   127 MLQ--VGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFADLKSFEILR 189
            .:.  ..:|..:..:..|.:|...:..|...         :.|.|:  .|..:|...||: |:|
Zfish   505 RVDRLTSKVDDLHKEGHFSFGLATVSLETNM---------ILYNIQ--RIIQQESVCLKN-EVL- 556

  Fly   190 KYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLLEDRLI 254
               :.|.|..|  :|..:.   ....:|.::.|..:.....||.:|||..:|:..    |:.:|:
Zfish   557 ---SSKLEGQN--HKMEDL---CEQNKRYMEQLPIQTCHIHSEQEKEDSLISSCQ----LQQQLV 609

  Fly   255 VYNNLAMTQIKI-----AAYD---------AALQS-VEHVLRCQPNNS---KALYRKGRILEG-- 299
               ||...:.:|     ||.|         :.|:: |..:|:.:..:.   :|..:|.:.||.
Zfish   610 ---NLQQRETEIQTQLSAALDDKHKHCAQISLLEAQVAELLKKEEQSDQRWRAEKQKYKELESTI 671

  Fly   300 ------KADTQGAIKLLQKVATLEPENRAVQSDLARLFIKARREEHNEKEMYQKMLGQAKKMEQN 358
                  ..|.:...:.||:|  |..:.|..:::..|:.::...|....::...::|.|.:|...:
Zfish   672 QNMDEEMQDLRAEKENLQQV--LSEKKRKWKAERERIIVEQEEEHERSQQEVLQLLMQLRKARHS 734

  Fly   359 TATRQKQ 365
            |....||
Zfish   735 TEALMKQ 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	11/96 (11%)
		TPR_11	196..284	CDD:290150	22/102 (22%)
		TPR repeat	196..220	CDD:276809	4/23 (17%)
		TPR repeat	252..282	CDD:276809	10/44 (23%)
		TPR_11	255..318	CDD:290150	18/88 (20%)
		TPR repeat	287..313	CDD:276809	7/36 (19%)
		TPR repeat	321..349	CDD:276809	3/27 (11%)
fkbp15a	XP_009299868.1	FKBP_C	192..286	CDD:306713
		SMC_N	<485..707	CDD:330553	48/261 (18%)
		SMC_N	<624..874	CDD:330553	24/120 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910