DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment zda and FKBP10

DIOPT Version :9

Sequence 1:	NP_001286579.1	Gene:	zda / 37144	FlyBaseID:	FBgn0034368	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	XP_011523401.1	Gene:	FKBP10 / 60681	HGNCID:	18169	Length:	601	Species:	Homo sapiens

Alignment Length:	360	Identity:	74/360 - (20%)
Similarity:	126/360 - (35%)	Gaps:	74/360 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 DILGNKQLIKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELN----FQCHVGDYEVIQ 119
            |:...|..::....:.|....||...|:.:..::.|.|.:||:.::..:    :..::|...:|.
Human   260 DVHNPKDAVQLETLELPPGCVRRAGAGDFMRYHYNGSLMDGTLFDSSYSRNHTYNTYIGQGYIIP 324

  Fly   120 GLDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIKYEEFADLKS 184
            |:|..|....:||..::::.....||..|   .|:.   :|..|.|.:.:.::|  :...||:..
Human   325 GMDQGLQGACMGERRRITIPPHLAYGENG---TGDK---IPGSAVLIFNVHVID--FHNPADVVE 381

  Fly   185 FEILRKYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDSEFDKEDLELSNSDTQTLL 249
            ...|    :|..|..|...|..:|..    |......||........|.|....|.|....:...
Human   382 IRTL----SRPSETCNETTKLGDFVR----YHYNCSLLDGTQLFTSGETDAGSHEPSRPHFRGQR 438

  Fly   250 EDRLIVYN-----NLAMTQIKIAAYDAALQSVEHVLRCQPNNSKALYRKGRILEGKADTQGA--- 306
            .|    |.     .|...:: |...|..||.:     | ....:.|.....:..|::..:|.
Human   439 HD----YGAPQEATLGANKV-IEGLDTGLQGM-----C-VGERRQLIVPPHLAHGESGARGVPGS 492

  Fly   307 ------IKLLQKVATL-----------EPENRAVQSDLAR----------LFIKARREEHNEKEM 344
                  ::|:.:...|           .|.|.....||.:          .||||:..|...:.|
Human   493 AVLLFEVELVSREDGLPTGYLFVWHKDPPANLFEDMDLNKDGEVPPEEFSTFIKAQVSEGKGRLM 557

  Fly   345 ----YQKMLGQAKKMEQNTATRQKQPL-VDNSKLK 374
                .:|.:|.   |.||....|...: ||..|||
Human   558 PGQDPEKTIGD---MFQNQDRNQDGKITVDELKLK 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zda	NP_001286579.1	FKBP_C	80..172	CDD:278674	21/95 (22%)
		TPR_11	196..284	CDD:290150	19/92 (21%)
		TPR repeat	196..220	CDD:276809	5/23 (22%)
		TPR repeat	252..282	CDD:276809	6/34 (18%)
		TPR_11	255..318	CDD:290150	12/87 (14%)
		TPR repeat	287..313	CDD:276809	4/34 (12%)
		TPR repeat	321..349	CDD:276809	9/41 (22%)
FKBP10	XP_011523401.1	FKBP_C	55..147	CDD:278674
		FKBP_C	167..259	CDD:278674
		FKBP_C	279..371	CDD:278674	21/97 (22%)
		FKBP_C	392..502	CDD:278674	21/124 (17%)
		EF-hand_7	523..587	CDD:290234	17/66 (26%)
		EFh	525..586	CDD:238008	16/63 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810