DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zda and FKBP14

DIOPT Version :9

Sequence 1:NP_001286579.1 Gene:zda / 37144 FlyBaseID:FBgn0034368 Length:397 Species:Drosophila melanogaster
Sequence 2:NP_060416.1 Gene:FKBP14 / 55033 HGNCID:18625 Length:211 Species:Homo sapiens


Alignment Length:202 Identity:50/202 - (24%)
Similarity:83/202 - (41%) Gaps:45/202 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 IKRTIKKAPQDSFRRPIRGELVTVNFTGKLDNGTVVENELNFQCH-----------VGDYEVIQG 120
            :|..:.:.|....|:...|:|:.|::.|.|:.    :..|....|           :|..|.::|
Human    27 VKIEVLQKPFICHRKTKGGDLMLVHYEGYLEK----DGSLFHSTHKHNNGQPIWFTLGILEALKG 87

  Fly   121 LDMVLPMLQVGEVSQVSVDSRFGYGSLGLKKEGESEYLVPPDAHLTYEIELLDIK-----YEEFA 180
            .|..|..:.|||..::.:....|||     |||:.:  :||::.|.:.|:||:|:     :|.|.
Human    88 WDQGLKGMCVGEKRKLIIPPALGYG-----KEGKGK--IPPESTLIFNIDLLEIRNGPRSHESFQ 145

  Fly   181 DLK-------SFEILRKYGTRKKERANFFYKRSEFTTAIHLYRRALDFLDNRDGDPDS-----EF 233
            ::.       |.:.::.|  .|||    |.|........|......|..|..|.|.|.     ||
Human   146 EMDLNDDWKLSKDEVKAY--LKKE----FEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREF 204

  Fly   234 DKEDLEL 240
            ..:..||
Human   205 TYKHDEL 211

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zdaNP_001286579.1 FKBP_C 80..172 CDD:278674 26/102 (25%)
TPR_11 196..284 CDD:290150 14/50 (28%)
TPR repeat 196..220 CDD:276809 5/23 (22%)
TPR repeat 252..282 CDD:276809
TPR_11 255..318 CDD:290150
TPR repeat 287..313 CDD:276809
TPR repeat 321..349 CDD:276809
FKBP14NP_060416.1 FkpA <43..135 CDD:223619 27/102 (26%)
EF-hand_7 141..204 CDD:404394 15/68 (22%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 208..211 0/2 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0545
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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